Meal Composition is a Determinant of Lispro-Induced Hypoglycemia in IDDM
| العنوان: | Meal Composition is a Determinant of Lispro-Induced Hypoglycemia in IDDM |
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| المؤلفون: | David S. Schade, Kristen R Castillo, Mark R. Burge |
| المصدر: | Diabetes Care. 20:152-155 |
| بيانات النشر: | American Diabetes Association, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Time Factors, endocrine system diseases, Injections, Subcutaneous, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Hypoglycemia, Internal medicine, Diabetes mellitus, Dietary Carbohydrates, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, Insulin lispro, Prospective Studies, Advanced and Specialized Nursing, Meal, Insulin Lispro, business.industry, digestive, oral, and skin physiology, nutritional and metabolic diseases, Postprandial Period, medicine.disease, Diet, Diabetes Mellitus, Type 1, Endocrinology, Postprandial, Regular insulin, Female, business, Postprandial Hypoglycemia, medicine.drug |
| الوصف: | OBJECTIVE Lispro is a newly FDA-approved analog of human insulin that will be widely used in patients with IDDM. This insulin, however, may have an increased potential for hypoglycemia because of its very rapid subcutaneous absorption, especially in a setting of decreased carbohydrate intake. Using a short-term prospective randomized parallel group-study design, we studied the incidence of hypoglycemia when lispro was given before breakfast compared with regular human insulin. Since carbohydrate intake is a determinant of postprandial glycemia, we administered three isocaloric meals characterized by low, average, and high carbohydrate content. RESEARCH DESIGN AND METHODS Two groups of six IDDM subjects were randomized to receive 0.15 U/kg of lispro or regular human insulin subcutaneously before the ingestion of three 500-kcal breakfast meals of differing carbohydrate content on separate days. Lispro was administered at mealtime, and regular insulin was administered 30 min before mealtime. RESULTS Postprandial plasma glucose concentrations were decreased in the lispro group compared with the regular-insulin group for all three meal types (P < 0.05), and hypoglycemia developed more frequently and rapidly in the lispro group, compared with the regular-insulin group by survival analysis. Additionally, peak insulin concentrations were higher (P < 0.001) and peaked more rapidly (P < 0.05) in the lispro group, compared with the regular-insulin group. CONCLUSIONS We conclude that lispro has a tendency for early postprandial hypoglycemia compared with regular insulin in the setting of reduced carbohydrate intake. This fact should be told to patients who decide to switch from regular insulin to lispro. Health care professionals should instruct their IDDM patients to monitor glucose levels frequently after switching to lispro since adjustments in their carbohydrate intake and/or their lispro dosage may be necessary to avoid hypoglycemia. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de15c54d6112f36aa5db406d739b2eaTest https://doi.org/10.2337/diacare.20.2.152Test |
| رقم الانضمام: | edsair.doi.dedup.....8de15c54d6112f36aa5db406d739b2ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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