نتائج البحث - "Kristen M. Kokkonen-Simon"

1

دورية أكاديمية

CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/7e6f8490744a4cef9d24e2c03e23c499Test

View record in DOAJ

النص الكامل

2

دورية أكاديمية

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

المؤلفون: Qing-Jun Zhang, Tram Anh T. Tran, Ming Wang, Mark J. Ranek, Kristen M. Kokkonen-Simon, Jason Gao, Xiang Luo, Wei Tan, Viktoriia Kyrychenko, Lan Liao, Jianming Xu, Joseph A. Hill, Eric N. Olson, David A. Kass, Elisabeth D. Martinez, Zhi-Ping Liu

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/7518fe10d5ab4b61a96ce3487b11c73bTest

View record in DOAJ

النص الكامل

3

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

المؤلفون: Masayuki Sasaki, Christian U. Oeing, Dong Ik Lee, Djahida Bedja, Mark J. Ranek, Taishi Nakamura, Jonathan D. Powell, Jennifer E. Van Eyk, Chirag H. Patel, Anna Chen, Miguel Pinilla Vera, Ronald J. Holewinski, Kristen M. Kokkonen-Simon, Guangshuo Zhu, David A. Kass, Brittany Dunkerly-Eyring

المصدر: Nature

مصطلحات موضوعية: Male, 0301 basic medicine, Heart Diseases, mTORC1, Mechanistic Target of Rapamycin Complex 1, 030204 cardiovascular system & hematology, Article, Mice, Phosphoserine, 03 medical and health sciences, 0302 clinical medicine, Tuberous Sclerosis Complex 2 Protein, Autophagy, Cyclic GMP-Dependent Protein Kinases, Pressure, Serine, Animals, Humans, Myocytes, Cardiac, Everolimus, Gene Knock-In Techniques, Phosphorylation, Rats, Wistar, Protein kinase A, Mechanistic target of rapamycin, Protein kinase B, Cells, Cultured, Pressure overload, Multidisciplinary, biology, Kinase, Chemistry, Hypertrophy, Rats, Cell biology, Enzyme Activation, HEK293 Cells, 030104 developmental biology, Mutation, Disease Progression, biology.protein, Female, biological phenomena, cell phenomena, and immunity, RHEB

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963ccf5739aaa5a72e9b1e7524e814d8Test
https://doi.org/10.1038/s41586-019-0895-yTest

4

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

المؤلفون: Wei Tan, Kristen M. Kokkonen-Simon, David A. Kass, Jason Gao, Viktoriia Kyrychenko, Elisabeth D. Martinez, Zhi Ping Liu, Lan Liao, Joseph A. Hill, Qing Jun Zhang, Tram Anh T. Tran, Mark J. Ranek, Jianming Xu, Xiang Luo, Eric N. Olson, Ming Wang

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Heart growth, Transgene, Science, General Physics and Astronomy, Aminopyridines, Cardiomegaly, Mice, Transgenic, Left ventricular hypertrophy, General Biochemistry, Genetics and Molecular Biology, Article, Rats, Sprague-Dawley, 03 medical and health sciences, Fibrosis, medicine, Animals, Humans, Myocytes, Cardiac, cardiovascular diseases, lcsh:Science, Loss function, Cells, Cultured, TIMP1, Histone Demethylases, Mice, Knockout, Multidisciplinary, biology, business.industry, Gene Expression Profiling, Myocardium, Hydrazones, General Chemistry, medicine.disease, 3. Good health, 030104 developmental biology, Histone, Animals, Newborn, Gene Expression Regulation, biology.protein, Cancer research, cardiovascular system, Demethylase, lcsh:Q, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a58d7ae7adcbc4db51c02b441cffabTest
http://link.springer.com/article/10.1038/s41467-018-07173-2Test

5

CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury

المصدر: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

مصطلحات موضوعية: Male, 0301 basic medicine, Science, Ubiquitin-Protein Ligases, Amino Acid Motifs, General Physics and Astronomy, macromolecular substances, Article, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Ischemia, Cyclic GMP-Dependent Protein Kinases, Animals, Humans, Phosphorylation, lcsh:Science, Multidisciplinary, biology, Chemistry, Myocardium, Protein turnover, Heart, General Chemistry, Cell biology, Myocardial infarction, Mechanisms of disease, 030104 developmental biology, Proteostasis, Proteasome, Proteotoxicity, Chaperone (protein), cardiovascular system, biology.protein, lcsh:Q, Female, cGMP-dependent protein kinase, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0da9f09773c6c255e955440f56caa0eTest
https://doi.org/10.1038/s41467-020-18980-xTest

6

PKG1α Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy

المؤلفون: Djahida Bedja, Taishi Nakamura, Dong Ik Lee, Mark J. Ranek, Brian L. Lin, Brittany Dunkerly-Eyring, Guangshuo Zhu, Kristen M. Kokkonen-Simon, Christian U. Oeing, Shi Pan, David A. Kass, Anna Chen, Sumita Mishra

المصدر: Circ Res

مصطلحات موضوعية: Hydrocarbons, Fluorinated, Physiology, Cardiomegaly, mTORC1, Constriction, Pathologic, Mechanistic Target of Rapamycin Complex 1, Benzoates, Article, Muscle hypertrophy, Serine, Mice, Tuberous Sclerosis Complex 2 Protein, Autophagy, Pressure, Animals, Myocytes, Cardiac, Cysteine, Everolimus, Gene Knock-In Techniques, Phosphorylation, Protein kinase A, Aorta, Cyclic GMP-Dependent Protein Kinase Type I, Endothelin-1, Chemistry, Biphenyl Compounds, Cell biology, Rats, Enzyme Activation, Mice, Inbred C57BL, Oxidative Stress, Guanylate Cyclase, Proteostasis, TSC2, biological phenomena, cell phenomena, and immunity, Cardiology and Cardiovascular Medicine, cGMP-dependent protein kinase, Oxidation-Reduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68348e928f0a927a2982088bab4928f4Test
https://pubmed.ncbi.nlm.nih.gov/32393148Test

7

Right Ventricular Myofilament Functional Differences in Humans With Systemic Sclerosis–Associated Versus Idiopathic Pulmonary Arterial Hypertension

المؤلفون: Fredrick M. Wigley, Marc K. Halushka, Kenneth B. Margulies, Steven Hsu, Rachel L. Damico, Paul M. Hassoun, Monica Mukherjee, Kristen M. Kokkonen-Simon, Ami A. Shah, Ryan J. Tedford, David A. Kass, Todd M. Kolb, Stephen C. Mathai, Jonathan A. Kirk

المصدر: Circulation. 137:2360-2370

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Myofilament, Heart Ventricles, Hypertension, Pulmonary, 030204 cardiovascular system & hematology, Sarcomere, Article, Contractility, 03 medical and health sciences, 0302 clinical medicine, Myofibrils, In vivo, Physiology (medical), Internal medicine, medicine, Humans, Myocyte, Familial Primary Pulmonary Hypertension, Prospective Studies, skin and connective tissue diseases, Exercise, Aged, Scleroderma, Systemic, integumentary system, business.industry, Myocardium, Hemodynamics, Idiopathic Pulmonary Arterial Hypertension, Middle Aged, medicine.disease, Pulmonary hypertension, 030228 respiratory system, Case-Control Studies, Cardiology, Calcium, Female, Cardiology and Cardiovascular Medicine, business, Myofibril, Muscle Contraction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6613723f5d08a96fe9ded025ae164e7Test
https://doi.org/10.1161/circulationaha.117.033147Test

8

Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease

المؤلفون: Marc K. Halushka, Guangshuo Zhu, Michaela Kuhn, Amir Saberi, Kristen M. Kokkonen-Simon, David A. Kass, Dong Ik Lee, Mark J. Ranek, Djahida Bedja, Taishi Nakamura

المصدر: JCI insight. 3(15)

مصطلحات موضوعية: 0301 basic medicine, Male, Heart Diseases, Pharmacology, Nitric Oxide, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, Mice, microRNA, Cyclic GMP-Dependent Protein Kinases, Animals, Humans, RNA Processing, Post-Transcriptional, Natriuretic Peptides, Cyclic guanosine monophosphate, Cyclic GMP, Pressure overload, Cyclic Nucleotide Phosphodiesterases, Type 5, Messenger RNA, Phosphodiesterase, General Medicine, Phosphodiesterase 5 Inhibitors, Disease Models, Animal, MicroRNAs, 030104 developmental biology, chemistry, 3',5'-Cyclic-AMP Phosphodiesterases, cGMP-specific phosphodiesterase type 5, cGMP-dependent protein kinase, Signal Transduction, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6d61ce299544b131e27e924921a2acTest
https://pubmed.ncbi.nlm.nih.gov/30089721Test

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Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation

المؤلفون: Kenichi Tsujita, Grace Kim, Kristen M. Kokkonen-Simon, Taishi Nakamura, Mark J. Ranek, David A. Kass, Manling Zhang, Guangshuo Zhu

المصدر: Circulation. Heart failure. 11(3)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e63dac5c51dff173b078d75e512ef1fTest
https://pubmed.ncbi.nlm.nih.gov/29545396Test

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