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المؤلفون: Timothy L. Ratliff, Renee E. Vickman, Kourtney M. Goode, Tony R. Hazbun, Dino P. Petrov, V. Jo Davisson, Pete E. Pascuzzi, Scott A. Crist
المصدر: Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:1992-2006
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Allosteric regulation, Biophysics, Down-Regulation, Biochemistry, Article, Hsp90 inhibitor, 03 medical and health sciences, 0302 clinical medicine, Allosteric Regulation, Phenols, Protein Domains, Downregulation and upregulation, Cell Line, Tumor, Humans, HSP90 Heat-Shock Proteins, Benzhydryl Compounds, Binding site, Heat shock, Molecular Biology, Adenosine Triphosphatases, Binding Sites, biology, BRCA1 Protein, Hsp90, Cell biology, 030104 developmental biology, Allosteric enzyme, 030220 oncology & carcinogenesis, biology.protein, CTD, Protein Multimerization
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f21eb48a1985f6d2a13f25cc0c447eTest
https://doi.org/10.1016/j.bbagen.2017.05.006Test -
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المؤلفون: Larisa Avramova, Fiona M. Thomas, Andrew A. Bieberich, V. Jo Davisson, Kourtney M. Goode, Tony R. Hazbun, Bartek Rajwa
المصدر: SLAS Discovery. 22:706-719
مصطلحات موضوعية: 0301 basic medicine, Phenotypic screening, Cell Culture Techniques, Haploidy, 01 natural sciences, Biochemistry, Article, Analytical Chemistry, Hsp90 inhibitor, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Heat shock protein, Drug Discovery, Humans, Structure–activity relationship, HSP90 Heat-Shock Proteins, Sequence Deletion, Genetics, Molecular Structure, biology, 010405 organic chemistry, Drug discovery, Macbecin, Hsp90, Yeast, High-Throughput Screening Assays, 0104 chemical sciences, Phenotype, 030104 developmental biology, chemistry, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, Signal Transduction, Biotechnology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21e64dda95cbc414278be25af70b016Test
https://doi.org/10.1177/2472555216687525Test -
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المؤلفون: Tony R. Hazbun, Jean-Christophe Rochet, Lake N. Paul, Holli M. Drendel, Kiran Aslam, Kourtney M. Goode, Chai-jui Tsai, Josephat M. Asiago
المصدر: Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications
مصطلحات موضوعية: Protein Folding, Saccharomyces cerevisiae Proteins, Prions, alpha-synuclein, Molecular Sequence Data, Saccharomyces cerevisiae, yeast, Protein aggregation, Biochemistry, prion, Protein Aggregates, chemistry.chemical_compound, Catalytic Domain, Heat shock protein, multifunctional protein, Humans, Amino Acid Sequence, Lactic Acid, protein misfolding, Protein Structure, Quaternary, Molecular Biology, Heat-Shock Proteins, Alpha-synuclein, biology, Autophagy, Lactoylglutathione Lyase, small heat shock protein (sHsp), stress response, Cell Biology, molecular chaperone, Pyruvaldehyde, biology.organism_classification, Cell biology, Parkinson disease, Oxidative Stress, enzyme, chemistry, Proteotoxicity, Chaperone (protein), Protein Structure and Folding, biology.protein, Protein folding, Protein Multimerization, Reactive Oxygen Species
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b378e5311ce0a0383b1d5d0dbd36e60Test
https://doi.org/10.1074/jbc.m115.678367Test -
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المصدر: Molecular Cancer Therapeutics. 14:B89-B89
مصطلحات موضوعية: Gene isoform, Genetics, Cancer Research, biology, Phenotypic screening, Saccharomyces cerevisiae, Computational biology, biology.organism_classification, medicine.disease_cause, Small molecule, Hsp90, Chemical library, chemistry.chemical_compound, Oncology, chemistry, Heat shock protein, biology.protein, medicine, Carcinogenesis
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::47c6738c9c95cd94950d7b29e27d18a3Test
https://doi.org/10.1158/1535-7163.targ-15-b89Test