دورية أكاديمية
Examining the Effects of Hyperbaric Oxygen Therapy on the Cardiovascular System and Oxidative Stress in Insulin-Treated and Non-Treated Diabetic Rats
| العنوان: | Examining the Effects of Hyperbaric Oxygen Therapy on the Cardiovascular System and Oxidative Stress in Insulin-Treated and Non-Treated Diabetic Rats |
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| المؤلفون: | Petar Ristic, Maja Savic, Sergey Bolevich, Stefani Bolevich, Alexandra Orlova, Anastasiya Mikhaleva, Anna Kartashova, Koka Yavlieva, Tamara Nikolic Turnic, Bozidar Pindovic, Katarina Djordjevic, Ivan Srejovic, Vladimir Zivkovic, Vladimir Jakovljevic |
| المصدر: | Animals, Vol 13, Iss 18, p 2847 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Veterinary medicine LCC:Zoology |
| مصطلحات موضوعية: | hyperbaric oxygen therapy, neutral protamine hagedorn (NPH) insulin, streptozotocin, type 1 diabetes (T1D), Veterinary medicine, SF600-1100, Zoology, QL1-991 |
| الوصف: | Background: This study explored the effects of hyperbaric oxygen therapy (HBOT) on the cardiovascular system and oxidative stress in streptozotocin-induced diabetic rats. Wistar albino rats were divided into four groups: DM group (diabetic rats), DM+HBOT group (diabetic rats exposed to HBOT for 1 h daily, five days a week, at 2.8 atmosphere absolute (ATA) with 100% oxygen for two weeks), DM+INS group (diabetic rats treated with neutral protamine hagedorn (NPH) insulin at a dosage of 3–5 U/day), and DM+HBOT+INS group (diabetic rats treated with both NPH insulin and HBOT for two weeks). Methods: Evaluations included glycemic control, oxidative stress parameters, and cardiac function measurements. Results: NPH insulin treatment reduced blood glucose levels, although normoglycemia was not achieved. The DM+HBOT+INS group demonstrated the lowest pro-oxidative marker levels. NPH insulin treatment improved cardiac function, and combination therapy effectively restored cardiac function in diabetic animals. Conclusions: NPH insulin treatment reduced hyperglycemia and improved cardiac function in diabetic rats. The combined approach of NPH insulin and HBOT resulted in decreased pro-oxidative markers. These findings provide valuable insights for managing cardiovascular complications and oxidative stress in diabetes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2076-2615 |
| العلاقة: | https://www.mdpi.com/2076-2615/13/18/2847Test; https://doaj.org/toc/2076-2615Test |
| DOI: | 10.3390/ani13182847 |
| الوصول الحر: | https://doaj.org/article/d653154a14e847b0b8f627d9d335891aTest |
| رقم الانضمام: | edsdoj.653154a14e847b0b8f627d9d335891a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20762615 |
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| DOI: | 10.3390/ani13182847 |