التفاصيل البيبلوغرافية
| العنوان: |
10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial. |
| المؤلفون: |
Halliday, A, Harrison, M, Hayter, E, Kong, X, Mansfield, A, Marro, J, Pan, H, Peto, R, Potter, J, Rahimi, K, Rau, A, Robertson, S, Streifler, J, Thomas, D, Fraedrich, G, Schmidauer, C, Hölzenbein, T. H, Huk, I, Haumer, M, Kretschmer, G, Metz, V, Polterauer, P, Teufelsbauer, H, Cras, P, Hendriks, J, Lauwers, P, van Schil, P, de Souza, E. B, Emilio Dourado, M, Gurgel, G, Myrian Rocha, G, Petrov, V, Slabakov, G, Cooper, M. E, Gubitz, G, Holness, R, Howes, W, Langille, R, Legg, K, Nearing, S, MacKean, G, MacKay, M, Phillips, S. J, Sullivan, J, Wood, J, Erdelez, L, Sosa, T, Angelides, N. S, Christopoulos, G, Malikidou, A, Pesta, A, Ambler, Z, Mracek, J, Polivka, J, Rohan, V, Sevcik, P, Simaná, J, Beneš, V, Kramár, F, Kaste, M, Lepäntalo, M, Soinne, L, Cardon, J. M, Legalou, A, Gengenbach, B, Pfadenhauer, K, Wölfle, K. D, Flessenkämper, I, Klumpp, B. F, Marsch, J, Kolvenbach, R, Pfeiffer, T, Sandmann, W, Beyersdorf, F, Hetzel, A, Sarai, K, Schöllhorn, J, Spillner, G, Lutz, H. J, Böckler, D, Maeder, N, Busse, O, Grönniger, J, Haukamp, F, Balzer, K, Knoob, H. G, Roedig, G, Virreira, L, Franke, S, Moll, R, Schneider, J, Dayantas, J, Sechas, M. N, Tsiaza, S, Kiskinis, D, Apor, A, Dzinich, C, Entz, L, Hüttl, K, Jàrànyi, Z, Mogan, I, Nagy, Z, Szabo, A, Varga, D, Juhász, G, Mátyás, L, Hutchinson, M, Mehigan, D, Aladjem, Z, Harah, E, Elmakias, S, Gurvich, D, Yoffe, B, Ben Meir, H, Dagan, L, Karmeli, R, Keren, G, Shimony, A, Weller, B, Avrahami, R, Koren, A, Streifler, J. Y, Tabachnik, S, Zelikovski, A, Angiletta, D, Federico, F, Impedovo, G, Marotta, V, Pascazio, L, Regina, G, Andreoli, A, Pozzati, E, Bonardelli, S, Giulini, S. M, Guarneri, B, Caiazzo, P, Mascoli, F, Becchi, G, Masini, R, Santoro, E, Simoni, G, Ventura, M, Scarpelli, P, Spartera, C, Arena, O, Collice, M, Puttini, M, Romani, F, Santilli, I, Segramora, V, Sterzi, R, Deriu, G, Verlato, F, Cao, P. G, Cieri, E, de Rango, P, Moggi, L, Ricci, S, Antico, A, Spigonardo, F, Malferrari, G, Tusini, N, Vecchiati, E, Cavallaro, A, Kasemi, H, Marino, M, Sbarigia, E, Speziale, F, Zinicola, N, Alò, F. P, Bartolini, M, Carbonari, L, Caporelli, S, Grili Cicilioni, C, Lagalla, G, Ioannidis, G, Pagliariccio, G, Silvestrini, M, Peinetti, F, Adovasio, R, Chiodo Grandi, F, Mase, G, Zamolo, F, Fregonese, V, Gonano, N, Mozzon, L, Blair, R, Chuen, J, Ferrar, D, Garbowski, M, Hamilton, M. J, Holdaway, C, Muthu, S, Shakibaie, F, Vasudevan, T. M, Kroese, A, Slagsvold, C. E, Dahl, T, Johnsen, H. J, Lange, C, Myhre, H. O, Gniadek, J, Andziak, P, Elwertowski, M, Leszczynski, J, Malek, A. K, Mieszkowski, J, Noszczyk, W, Szostek, M, Toutounchi, S, Correia, C, Pereira, M. C, Akchurin, R. S, Flis, V, Miksic, K, Stirn, B, Tetickovic, E, Cairols, M, Capdevila, J. M, Iborra Ortega, E, Obach, V, Riambau, V, Vidal Barraquer, F, Vila Coll, R, Diaz Vidal, E, Iglesias Negreia, J. I, Tovar Pardo, A, Segura Iglesias, R. J, Alfageme, A. F, Barba Velez, A, Estallo Laliena, L, Garcia Monco, J. C, Rodriguez Gonzalez, L, Corominas, C, Julia, J, Lozano, P, Marti Masso, J. F, Porta, R. M, Rosendo Carrera, A, Gomez, J, Blomstrand, C, Gelin, J, Holm, J, Karlström, L, Mattsson, E, Bornhov, S, Dahlstrom, J, de Pedis, G, Jensen, S. M, Pärsson, H, Plate, G, Qvarfordt, P, Arvidsson, B, Brattström, L, Forssell, C, Potemkowski, A, Skiöldebrand, C, Stoor, P, Blomqvist, M, Calander, M, Lundgren, F, Almqvist, H, Norgren, L, Norrving, B, Ribbe, E, Thörne, J, Gottsäter, A, Mätzsch, T, Nilsson, M. E, Lonsson, M, Stahre, B, Stenberg, B, Konrad, P, Jarl, L, Lundqvist, L, Olofsson, P, Rosfors, S, Swedenborg, J, Takolander, R, Bergqvist, D, Ljungman, C, Kniemeyer, H. W, Widmer, M. K, Kuster, R, Kaiser, R, Nagel, W, Sege, D, Weder, B, de Nie, J, Doelman, J, Yilmaz, N, Buth, J, Stultiens, G, Boiten, J, Boon, A, van der Linden, F, Busman, D. C, Sinnige, H. A. W, Yo, T. I, de Borst, G. J, Eikelboom, B. C, Kappelle, L. J, Moll, F, van Reedt Dortland, R. W. H, Westra, T. E, Jaber, H, Manaa, J, Meftah, R. B, Nabil, B. R, Sraieb, T, Bateman, D, Budd, J, Horrocks, M, Kivela, M, Shaw, L, Walker, R, D'Sa, A. A. B. B, Simms, M, Baird, R, Campbell, M, Cole, S, Ferguson, I. T, Lamont, P, Mitchell, D, Sassano, A, Smith, F. C. T, Blake, K, Kirkpatrick, P. J, Martin, P, Turner, C, Clegg, J. F, Crosley, M, Hall, J, de Cossart, L, Edwards, P, Fletcher, D, Rosser, S, McCollum, P. T, Davidson, D, Levison, R, Bradbury, A. W, Chalmers, R. T. A, Dennis, M, Murie, J, Ruckley, C. V, Sandercock, P, Campbell, W. B, Frankel, T, Gardner Thorpe, C, Gutowski, N, Hardie, R, Honan, W, Niblett, P, Peters, A, Ridler, B, Thompson, J. F, Bone, I, Welch, G, Grocott, E. C, Overstall, P, Aldoori, M. I, Dafalla, B. E. A, Bryce, J, Clarke, C, Ming, A, Wilkinson, A. R, Bamford, J, Berridge, D, Scott, J, Abbott, R. J, Naylor, R, Harris, P, Humphrey, P, Adiseshiah, M, Aukett, M, Baker, D, Bishop, C. C. R, Boutin, A, Brown, M, Burke, P, Burnand, K. G, Colchester, A, Coward, L, Davies, A. H, Espasandin, M, Giddings, A. E. B, Hamilton, G, Judge, C, Kakkos, S, McGuiness, C, Morris Vincent, P, Nicolaides, A, Padayachee, T. S, Riordan, H, Sullivan, E, Taylor, P, Thompson, M, Wolfe, J. H. N, McCollum, C. N, O'Neill, P. A, Welsh, S, Barnes, J, Cleland, P, Davis, M, Gholkar, A, Jones, R, Jaykishnam, V, Mendelow, A. D, O'Connell, J. E, Siddique, M. S. S, Stansby, G, Vivar, R, Ashley, S, Cosgrove, C, Gibson, J, Wilkins, D. C, Chant, A. D. B, Frankel, J, Shearman, C. P, Williams, J, Hall, G, Holdsworth, R, Davies, J. N, McLean, B, Woodburn, K. R, Brown, G, Curley, P, Loizou, L, Chaturvedi, S, Diaz, F, Radak, D, Todorovic, P. R, Kamugasha, D, Baxter, A, Berry, C, Burrett, J, Collins, R, Crowther, J, Davies, C, Farrell, B, Godwin, J, Gray, R, Harwood, C, Hirt, L, Hope, C, Knight, S, Lay, M, Munday, A, Murawska, A, Peto, C. G, Radley, A, Richards, S., PALOMBO, DOMENICO |
| المساهمون: |
Halliday, A, Harrison, M, Hayter, E, Kong, X, Mansfield, A, Marro, J, Pan, H, Peto, R, Potter, J, Rahimi, K, Rau, A, Robertson, S, Streifler, J, Thomas, D, Fraedrich, G, Schmidauer, C, Hölzenbein, T. H, Huk, I, Haumer, M, Kretschmer, G, Metz, V, Polterauer, P, Teufelsbauer, H, Cras, P, Hendriks, J, Lauwers, P, van Schil, P, de Souza, E. B, Emilio Dourado, M, Gurgel, G, Myrian Rocha, G, Petrov, V, Slabakov, G, Cooper, M. E, Gubitz, G, Holness, R, Howes, W, Langille, R, Legg, K, Nearing, S, Mackean, G, Mackay, M, Phillips, S. J, Sullivan, J, Wood, J, Erdelez, L, Sosa, T, Angelides, N. S, Christopoulos, G, Malikidou, A, Pesta, A, Ambler, Z, Mracek, J, Polivka, J, Rohan, V, Sevcik, P, Simaná, J, Beneš, V, Kramár, F, Kaste, M, Lepäntalo, M, Soinne, L, Cardon, J. M, Legalou, A, Gengenbach, B, Pfadenhauer, K, Wölfle, K. D, Flessenkämper, I, Klumpp, B. F, Marsch, J, Kolvenbach, R, Pfeiffer, T, Sandmann, W, Beyersdorf, F, Hetzel, A, Sarai, K, Schöllhorn, J, Spillner, G, Lutz, H. J, Böckler, D, Maeder, N, Busse, O, Grönniger, J, Haukamp, F, Balzer, K, Knoob, H. G, Roedig, G, Virreira, L, Franke, S, Moll, R, Schneider, J, Dayantas, J, Sechas, M. N, Tsiaza, S, Kiskinis, D, Apor, A, Dzinich, C, Entz, L, Hüttl, K, Jàrànyi, Z |
| بيانات النشر: |
Elsevier
GBR
Londra |
| سنة النشر: |
2010 |
| المجموعة: |
Università degli Studi di Genova: CINECA IRIS |
| مصطلحات موضوعية: |
Carotid Stenosis/complication, Carotid Stenosis/mortality, Endarterectomy, Carotid*/mortality, Stroke/epidemiology, Stroke/prevention & control |
| الوصف: |
BACKGROUND: If carotid artery narrowing remains asymptomatic (ie, has caused no recent stroke or other neurological symptoms), successful carotid endarterectomy (CEA) reduces stroke incidence for some years. We assessed the long-term effects of successful CEA. METHODS: Between 1993 and 2003, 3120 asymptomatic patients from 126 centres in 30 countries were allocated equally, by blinded minimised randomisation, to immediate CEA (median delay 1 month, IQR 0·3-2·5) or to indefinite deferral of any carotid procedure, and were followed up until death or for a median among survivors of 9 years (IQR 6-11). The primary outcomes were perioperative mortality and morbidity (death or stroke within 30 days) and non-perioperative stroke. Kaplan-Meier percentages and logrank p values are from intention-to-treat analyses. This study is registered, number ISRCTN26156392. FINDINGS: 1560 patients were allocated immediate CEA versus 1560 allocated deferral of any carotid procedure. The proportions operated on while still asymptomatic were 89·7% versus 4·8% at 1 year (and 92·1%vs 16·5% at 5 years). Perioperative risk of stroke or death within 30 days was 3·0% (95% CI 2·4-3·9; 26 non-disabling strokes plus 34 disabling or fatal perioperative events in 1979 CEAs). Excluding perioperative events and non-stroke mortality, stroke risks (immediate vs deferred CEA) were 4·1% versus 10·0% at 5 years (gain 5·9%, 95% CI 4·0-7·8) and 10·8% versus 16·9% at 10 years (gain 6·1%, 2·7-9·4); ratio of stroke incidence rates 0·54, 95% CI 0·43-0·68, p<0·0001. 62 versus 104 had a disabling or fatal stroke, and 37 versus 84 others had a non-disabling stroke. Combining perioperative events and strokes, net risks were 6·9% versus 10·9% at 5 years (gain 4·1%, 2·0-6·2) and 13·4% versus 17·9% at 10 years (gain 4·6%, 1·2-7·9). Medication was similar in both groups; throughout the study, most were on antithrombotic and antihypertensive therapy. Net benefits were significant both for those on lipid-lowering therapy and for those not, and both for men and for ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
STAMPA |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/pmid/20870099; info:eu-repo/semantics/altIdentifier/wos/WOS:000282411600034; volume:376; firstpage:1074; lastpage:1084; numberofpages:11; journal:THE LANCET; http://hdl.handle.net/11567/351711Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-77957189028 |
| DOI: |
10.1016/S0140-6736(10)61197-X |
| الإتاحة: |
https://doi.org/10.1016/S0140-6736Test(10)61197-X
http://hdl.handle.net/11567/351711Test |
| رقم الانضمام: |
edsbas.E560FE4C |
| قاعدة البيانات: |
BASE |
