دورية أكاديمية
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
| العنوان: | Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging |
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| المؤلفون: | Baar, M.P. (Marjolein), Brandt, R.M.C. (Renata), Putavet, D., Klein, J.D.D. (Julian D.D.), Derks, K.W.J. (Kasper), Bourgeois, B.R.M. (Benjamin R.M.), Stryeck, S. (Sarah), Rijksen, Y.M. (Yvonne), van Willigenburg, H. (Hester), Feijtel, D.A. (Danny A.), Pluijm, I. (Ingrid) van der, Essers, J. (Jeroen), Cappellen, W.A. (Gert) van, IJcken, W.F.J. (Wilfred) van, Houtsmuller, A.B. (Adriaan), Pothof, J. (Joris), Bruin, R.W.F. (Ron) de, Madl, T. (Tobias), Hoeijmakers, J.H.J. (Jan), Campisi, J. (Judith), Keizer, P.L.J. (Peter) de |
| المصدر: | Cell vol. 169 no. 1, pp. 132-147.e16 |
| سنة النشر: | 2017 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: | aging, apoptosis, cell-penetrating peptide, chemotherapy, FOXO4, IL6, LMNB1, Senescence, tissue homeostasis, TP53 |
| الوصف: | The accumulation of irreparable cellular damage restricts healthspan after acute stress or natural aging. Senescent cells are thought to impair tissue function, and their genetic clearance can delay features of aging. Identifying how senescent cells avoid apoptosis allows for the prospective design of anti-senescence compounds to address whether homeostasis can also be restored. Here, we identify FOXO4 as a pivot in senescent cell viability. We designed a FOXO4 peptide that perturbs the FOXO4 interaction with p53. In senescent cells, this selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis. Under conditions where it was well tolerated in vivo, this FOXO4 peptide neutralized doxorubicin-induced chemotoxicity. Moreover, it restored fitness, fur density, and renal function in both fast aging XpdTTD/TTD and naturally aged mice. Thus, therapeutic targeting of senescent cells is feasible under conditions where loss of health has already occurred, and in doing so tissue homeostasis can effectively be restored. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://repub.eur.nl/pub/98786Test; urn:hdl:1765/98786 |
| DOI: | 10.1016/j.cell.2017.02.031 |
| الإتاحة: | https://doi.org/10.1016/j.cell.2017.02.031Test http://repub.eur.nl/pub/98786Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DDBC3EBD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cell.2017.02.031 |
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