المؤلفون: Guiping Kong, Luming Zhou, Anja Freiwald, Kirill Shkura, Simone Di Giovanni

المصدر: STAR Protocols, Vol 3, Iss 1, Pp 101166- (2022)

مصطلحات موضوعية: Mass Spectrometry, Model Organisms, Molecular Biology, Neuroscience, Protein Biochemistry, Proteomics, Science (General), Q1-390

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666166722000466Test; https://doaj.org/toc/2666-1667Test

الوصول الحر: https://doaj.org/article/95c92a45dd8a43dd8947d976dff1f99fTest

المؤلفون: Liisi Laaniste, Prashant K. Srivastava, Julianna Stylianou, Nelofer Syed, Silvia Cases‐Cunillera, Kirill Shkura, Qingyu Zeng, Owen J. L. Rackham, Sarah R. Langley, Andree Delahaye-Duriez, Kevin O'Neill, Matthew Williams, Albert Becker, Federico Roncaroli, Enrico Petretto, Michael R. Johnson

المصدر: Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1616-1638 (2019)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2328-9503Test

الوصول الحر: https://doaj.org/article/5ca9a4cac564403083ba4ad6d5267303Test

المؤلفون: Huimei Chen, Aida Moreno-Moral, Francesco Pesce, Nithya Devapragash, Massimiliano Mancini, Ee Ling Heng, Maxime Rotival, Prashant K. Srivastava, Nathan Harmston, Kirill Shkura, Owen J. L. Rackham, Wei-Ping Yu, Xi-Ming Sun, Nicole Gui Zhen Tee, Elisabeth Li Sa Tan, Paul J. R. Barton, Leanne E. Felkin, Enrique Lara-Pezzi, Gianni Angelini, Cristina Beltrami, Michal Pravenec, Sebastian Schafer, Leonardo Bottolo, Norbert Hubner, Costanza Emanueli, Stuart A. Cook, Enrico Petretto

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/cfb1b8ece2684ea692a537c58f79dad3Test

المؤلفون: Prashant K. Srivastava, Jonathan van Eyll, Patrice Godard, Manuela Mazzuferi, Andree Delahaye-Duriez, Juliette Van Steenwinckel, Pierre Gressens, Benedicte Danis, Catherine Vandenplas, Patrik Foerch, Karine Leclercq, Georges Mairet-Coello, Alvaro Cardenas, Frederic Vanclef, Liisi Laaniste, Isabelle Niespodziany, James Keaney, Julien Gasser, Gaelle Gillet, Kirill Shkura, Seon-Ah Chong, Jacques Behmoaras, Irena Kadiu, Enrico Petretto, Rafal M. Kaminski, Michael R. Johnson

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/c0cffc3635504945bbe2f39f8175da2fTest

المؤلفون: Huimei Chen, Aida Moreno-Moral, Francesco Pesce, Nithya Devapragash, Massimiliano Mancini, Ee Ling Heng, Maxime Rotival, Prashant K. Srivastava, Nathan Harmston, Kirill Shkura, Owen J. L. Rackham, Wei-Ping Yu, Xi-Ming Sun, Nicole Gui Zhen Tee, Elisabeth Li Sa Tan, Paul J. R. Barton, Leanne E. Felkin, Enrique Lara-Pezzi, Gianni Angelini, Cristina Beltrami, Michal Pravenec, Sebastian Schafer, Leonardo Bottolo, Norbert Hubner, Costanza Emanueli, Stuart A. Cook, Enrico Petretto

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/28195d5a2cfd4a2ca91a728a572eb369Test

المؤلفون: Simone Di Giovanni, Eilidh McLachlan, Ilaria Palmisano, Radhika Puttagunta, Paolo La Montanara, Kirill Shkura, Thomas H. Hutson, Guiping Kong, Luming Zhou, Elisabeth Serger, Francesco De Virgiliis, Anja Freiwald

المساهمون: International Spinal Research Trust, Wings for Life Spinal Cord Research Foundation, The Weizmann Institute of Science

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism, Regeneration (biology), medicine.medical_treatment, Central nervous system, AMPK, Cell Biology, Biology, medicine.disease, medicine.anatomical_structure, Dorsal root ganglion, Axoplasm, nervous system, Physiology (medical), Peripheral nervous system, Internal Medicine, medicine, Axotomy, Spinal cord injury, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5a5a74d57735259d8e556cc39dcae5Test
http://hdl.handle.net/10044/1/81976Test

المؤلفون: Andrée Delahaye-Duriez, Julianna Stylianou, Kirill Shkura, Federico Roncaroli, Sarah R. Langley, Nelofer Syed, Albert J. Becker, Prashant K. Srivastava, Liisi Laaniste, Enrico Petretto, Qingyu Zeng, Marvin Johnson, Kevin O’Neill, Matthew Williams, Owen J. L. Rackham, Silvia Cases-Cunillera

المساهمون: UCB Biopharma SPRL

المصدر: Laaniste, L, Srivastava, P K, Stylianou, J, Syed, N, Cases-Cunillera, S, Shkura, K, Zeng, Q, Rackham, O J L, Langley, S R, Delahaye-Duriez, A, O'Neill, K, Williams, M, Becker, A, Roncaroli, F, Petretto, E & Johnson, M R 2019, ' Integrated systems-genetic analyses reveal a network target for delaying glioma progression ', Annals of clinical and translational neurology, vol. 6, no. 9, pp. 1616-1638 . https://doi.org/10.1002/acn3.50850Test
Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1616-1638 (2019)
Annals of Clinical and Translational Neurology

مصطلحات موضوعية: 0301 basic medicine, NF-KAPPA-B, Gene regulatory network, Gene mutation, CHEMOPREVENTIVE AGENT RESVERATROL, 0302 clinical medicine, Medicine, Gene Regulatory Networks, TRANSCRIPTION FACTOR, Research Articles, LEVEL ANALYSIS, Brain Neoplasms, General Neuroscience, Astrocytoma, Glioma, GRADE GLIOMA, CANCER, Gene Expression Regulation, Neoplastic, Disease Progression, Functional genomics, Life Sciences & Biomedicine, Research Article, RC321-571, EXPRESSION, Clinical Neurology, Neurosciences. Biological psychiatry. Neuropsychiatry, 03 medical and health sciences, Cell Line, Tumor, Humans, CELL-CYCLE, RC346-429, neoplasms, Cell Proliferation, Science & Technology, COMPLEX, business.industry, Gene Expression Profiling, Neurosciences, FOXM1, medicine.disease, nervous system diseases, Gene expression profiling, 030104 developmental biology, Mutation, Cancer research, Neurology (clinical), Neurosciences & Neurology, Neurology. Diseases of the nervous system, business, 030217 neurology & neurosurgery, Anaplastic astrocytoma

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9856ad195da8e008d955d780c30cc79Test
https://www.research.manchester.ac.uk/portal/en/publications/integrated-systemsgenetic-analyses-reveal-a-network-target-for-delaying-glioma-progressionTest(289e59de-ac87-4ea5-992b-bc9d64d85778).html

المؤلفون: Leanne E. Felkin, Kirill Shkura, Elisabeth Tan, Nithya Devapragash, Nathan Harmston, Aida Moreno-Moral, Leonardo Bottolo, Maxime Rotival, Owen J. L. Rackham, Prashant K. Srivastava, Gianni D Angelini, Cristina Beltrami, Costanza Emanueli, Francesco Pesce, Xi-Ming Sun, Huimei Chen, Enrique Lara-Pezzi, Norbert Hubner, Wei-Ping Yu, Michal Pravenec, Ee Ling Heng, Stuart A. Cook, Enrico Petretto, Paul J.R. Barton, Massimiliano Mancini, Sebastian Schafer, Nicole Tee

المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)

مصطلحات موضوعية: Adult, Male, Adolescent, Heart Diseases, Cardiac fibrosis, Science, Ubiquitin-Protein Ligases, MEDLINE, General Physics and Astronomy, WWP2, Mice, Transgenic, Smad2 Protein, Bioinformatics, General Biochemistry, Genetics and Molecular Biology, Mice, Young Adult, Text mining, Transforming Growth Factor beta, Medicine, Animals, Humans, Protein Isoforms, Gene Regulatory Networks, Genetic Predisposition to Disease, lcsh:Science, Author Correction, Pathological, Aged, Extracellular Matrix Proteins, Science & Technology, Multidisciplinary, business.industry, General Chemistry, Middle Aged, medicine.disease, Fibrosis, Multidisciplinary Sciences, Gene Expression Regulation, Ubiquitin ligases, Science & Technology - Other Topics, lcsh:Q, Female, business, Cardiomyopathies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bc5459ea4a4cb8b6dd33f1bddb0474Test
http://europepmc.org/articles/PMC6733793Test

المؤلفون: Cristina Beltrami, Owen J. L. Rackham, Costanza Emanueli, Nithya Devapragash, Wei-Ping Yu, Xi-Ming Sun, Stuart A. Cook, Norbert Hubner, Francesco Pesce, Ee Ling Heng, Elisabeth Tan, Aida Moreno-Moral, Enrique Lara-Pezzi, Gianni D Angelini, Enrico Petretto, Huimei Chen, Paul J.R. Barton, Nathan Harmston, Michal Pravenec, Sebastian Schafer, Maxime Rotival, Nicole Tee, Massimilano Mancini, Leanne E. Felkin, Leonardo Bottolo, Prashant K. Srivastava, Kirill Shkura

المساهمون: Cardiovascular and Metabolic Disorders [Singapor] (cvmd), Duke-NUS Medical School [Singapore], Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Ospedale San Giovanni di Dio, Firenze, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Faculty of Medicine [London, UK], Imperial College London, Agency for science, technology and research [Singapore] (A*STAR), Institute of Molecular and Cell Biology, National University of Singapore (NUS)-Agency for science, technology and research [Singapore] (A*STAR), MRC London Institute of Medical Sciences (LMC), National Heart Centre Singapore (NHCS), Royal Brompton and Harefield NHS Foundation Trust, Cardiovascular Research Centre [London], Centro Nacional de Investigaciones Cardiovasculares Carlos III [Madrid, Spain] (CNIC), Instituto de Salud Carlos III [Madrid] (ISC), University of Bristol [Bristol], Institute of Physiology [Prague], Czech Academy of Sciences [Prague] (CAS), University of Cambridge [UK] (CAM), The Alan Turing Institute, MRC Biostatistics Unit [Cambridge, UK], Max Delbrück Center for Molecular Medicine [Berlin] (MDC), Helmholtz-Gemeinschaft = Helmholtz Association, German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], The research was primarily supported by National Medical Research Council (NMRC) Singapore grant NMRC/CBRG/0106/2016 (to E.P.) and the British Heart Foundation (BHF) Ph.D. Studentship grant FS/11/25/28740 (to E.P). We acknowledge additional funding support from European Union FP7 CardioNeT-ITN-289600 (to E.L.-P., S.A.C., and P.J.R.B.), Heart Research UK (to P.J.R.B.), NIHR CV BRU of Royal Brompton and Harefield, NHS Foundation Trust (to S.A.C. and P.J.R.B.), BHF (to S.A.C.), Leducq Foundation (to S.A.C.), MRC UK (to S.A.C.), BHF Program Grant no. RG/15/5/31446 (to C.E. and E.P.). M.P. was supported by Praemium Academiae award of the Czech Academy of Sciences and grant 14-36804G from the Czech Science Foundation., We wish to thank Dr. Jacques Behmoaras for contributing critical and constructive comments to the manuscript., European Project: 289600,EC:FP7:PEOPLE,FP7-PEOPLE-2011-ITN,CARDIONET(2012), Moreno-Moral, Aida [0000-0002-8155-3146], Barton, Paul J. R. [0000-0002-1165-7767], Schafer, Sebastian [0000-0002-6909-8275], Bottolo, Leonardo [0000-0002-6381-2327], Cook, Stuart A. [0000-0001-6628-194X], Petretto, Enrico [0000-0003-2163-5921], Apollo - University of Cambridge Repository, National Medical Research Council (Singapur), British Heart Foundation, Unión Europea. Comisión Europea, National Institutes of Health (Estados Unidos), Czech Science Foundation, Fondation Leducq, NHS Foundation Trusth, University of Bari Aldo Moro (UNIBA), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Leducq Foundation for Cardiovascular Research, Commission of the European Communities, Heart Research UK, Medical Research Council (MRC), Barton, Paul JR [0000-0002-1165-7767], Cook, Stuart A [0000-0001-6628-194X]

المصدر: Nature Communications
Nature Communications, 2019, 10 (1), pp.3616. ⟨10.1038/s41467-019-11551-9⟩
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Chen, H, Moreno-Moral, A, Pesce, F, Devapragash, N, Mancini, M, Heng, E L, Rotival, M, Srivastava, P K, Harmston, N, Shkura, K, Rackham, O J L, Yu, W P, Sun, X M, Tee, N G Z, Tan, E L S, Barton, P J R, Felkin, L E, Lara-Pezzi, E, Angelini, G, Beltrami, C, Pravenec, M, Schafer, S, Bottolo, L, Hubner, N, Emanueli, C, Cook, S A & Petretto, E 2019, ' WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signalling ', Nature Communications, vol. 10, 3616 . https://doi.org/10.1038/s41467-019-11551-9Test
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.3616. ⟨10.1038/s41467-019-11551-9⟩
Repisalud
Instituto de Salud Carlos III (ISCIII)

مصطلحات موضوعية: Male, 45/43, BLOOD-PRESSURE, 02 engineering and technology, MESH: Protein Isoforms, MESH: Heart Diseases / genetics, Mice, Transforming Growth Factor beta, 42/44, Fibrosis, Protein Isoforms, Medicine, MESH: Animals, lcsh:Science, MESH: Ubiquitin-Protein Ligases / genetics, MESH: Fibrosis / metabolism, MESH: Genetic Predisposition to Disease* / genetics, GENE-EXPRESSION, Regulation of gene expression, Extracellular Matrix Proteins, MESH: Middle Aged, MESH: Fibrosis / genetics, TGF-BETA, MESH: Heart Diseases / metabolism, MESH: Ubiquitin-Protein Ligases / metabolism, 3. Good health, Cell biology, Ubiquitin ligase, FIBROBLAST, MESH: Young Adult, Science & Technology - Other Topics, 64/60, Cardiomyopathies, 0210 nano-technology, Cardiac function curve, Science, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, REVEALS, Humans, Aged, MESH: Adolescent, Science & Technology, MESH: Humans, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], IDENTIFICATION, MESH: Smad2 Protein / metabolism, MESH: Extracellular Matrix Proteins / metabolism, MESH: Adult, MESH: Cardiomyopathies / metabolism, medicine.disease, 030104 developmental biology, Cardiovascular and Metabolic Diseases, E3 UBIQUITIN LIGASE, RAT, DETERMINANT, lcsh:Q, Myocardial fibrosis, MESH: Female, 0301 basic medicine, Cardiac fibrosis, General Physics and Astronomy, Smad2 Protein, Gene Regulatory Networks, 13/89, MESH: Aged, MESH: Transforming Growth Factor beta / metabolism, Multidisciplinary, biology, MESH: Smad2 Protein / genetics, article, Middle Aged, MESH: Cardiomyopathies / genetics, 021001 nanoscience & nanotechnology, 692/4019/592/75/74, MESH: Gene Expression Regulation, Multidisciplinary Sciences, Centre for Surgical Research, HEART-FAILURE, Female, 38/39, Adult, Adolescent, Heart Diseases, MESH: Mice, Transgenic, Ubiquitin-Protein Ligases, Mice, Transgenic, 14/32, 82/80, Young Adult, Animals, Genetic Predisposition to Disease, 14/35, MESH: Mice, Pressure overload, business.industry, General Chemistry, MESH: Male, Gene Expression Regulation, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Ubiquitin ligases, Heart failure, 13/51, biology.protein, 631/45/474/2073, MESH: Gene Regulatory Networks, business

وصف الملف: application/pdf; text; application/zip; text/xml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9a8eae768aaa77cac0482318b75243Test
https://doi.org/10.1038/s41467-019-11551-9Test

المؤلفون: Kirill Shkura, Seon-Ah Chong, Gaëlle Gillet, Pierre Gressens, James Keaney, Jacques Behmoaras, Andrée Delahaye-Duriez, Catherine Vandenplas, Isabelle Niespodziany, Bénédicte Danis, Patrik Foerch, Marvin Johnson, Liisi Laaniste, Karine Leclercq, Manuela Mazzuferi, Prashant K. Srivastava, Frederic Vanclef, Juliette Van Steenwinckel, Julien Gasser, Enrico Petretto, Irena Kadiu, Patrice Godard, Alvaro Cardenas, Jonathan van Eyll, Georges Mairet-Coello, Rafal M. Kaminski

المساهمون: Commission of the European Communities, UCB Biopharma SPRL, Imperial College Healthcare NHS Trust- BRC Funding, Medical Research Council (MRC)

المصدر: Epilepsy Currents
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Srivastava, P K, van Eyll, J, Godard, P, Mazzuferi, M, Delahaye-Duriez, A, Steenwinckel, J V, Gressens, P, Danis, B, Vandenplas, C, Foerch, P, Leclercq, K, Mairet-Coello, G, Cardenas, A, Vanclef, F, Laaniste, L, Niespodziany, I, Keaney, J, Gasser, J, Gillet, G, Shkura, K, Chong, S-A, Behmoaras, J, Kadiu, I, Petretto, E, Kaminski, R M & Johnson, M R 2018, ' A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target ', Nature Communications, vol. 9, no. 1, pp. 3561 . https://doi.org/10.1038/s41467-018-06008-4Test

مصطلحات موضوعية: 0301 basic medicine, Computer science, General Physics and Astronomy, Disease, Epileptogenesis, DISEASE, Epilepsy, Mice, 0302 clinical medicine, DRIVERS, Drug Discovery, TEMPORAL-LOBE EPILEPSY, NETWORK, EEG, Molecular Targeted Therapy, lcsh:Science, PILOCARPINE MODEL, health care economics and organizations, GENE-EXPRESSION, Regulation of gene expression, Multidisciplinary, Drug discovery, Systems Biology, Pilocarpine, High-Throughput Nucleotide Sequencing, Current Literature in Basic Science, 3. Good health, Multidisciplinary Sciences, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Science & Technology - Other Topics, Anticonvulsants, Causal reasoning, Systems biology, Science, education, Computational biology, Muscarinic Agonists, behavioral disciplines and activities, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, Animals, Humans, Computer Simulation, CELL, Genetic Association Studies, Science & Technology, Sequence Analysis, RNA, Gene Expression Profiling, General Chemistry, medicine.disease, Gene expression profiling, Disease Models, Animal, 030104 developmental biology, OPINION, Epilepsy, Temporal Lobe, Gene Expression Regulation, SEIZURES, lcsh:Q, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c628bab6c1290f55dc9c3b73de6332f5Test
https://pubmed.ncbi.nlm.nih.gov/31035818Test