دورية أكاديمية
Genetic Features of HIV-1 Integrase Sub-Subtype A6 Predominant in Russia and Predicted Susceptibility to INSTIs
| العنوان: | Genetic Features of HIV-1 Integrase Sub-Subtype A6 Predominant in Russia and Predicted Susceptibility to INSTIs |
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| المؤلفون: | Kirichenko, A. (Alina), Lapovok, I. (Ilya), Baryshev, P. (Pavel), Vijver, D.A.M.C. (David) van de, Kampen, J.J.A. (Jeroen) van, Boucher, C.A.B. (Charles), Paraskevis, D. (Dimitrios), Kireev, D. (Dmitry) |
| المصدر: | Viruses vol. 12 no. 8 |
| سنة النشر: | 2020 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: | A6, founder effect, genetic barrier, HIV-1, INSTI, integrase, L74I, phylogenetics, polymorphisms, Russia |
| الوصف: | The increasing use of the integrase strand transfer inhibitor (INSTI) class for the treatment of HIV-infection has pointed to the importance of analyzing the features of HIV-1 subtypes for an improved understanding of viral genetic variability in the occurrence of drug resistance (DR). In this study, we have described the prevalence of INSTI DR in a Russian cohort and the genetic features of HIV-1 integrase sub-subtype A6. We included 408 HIV infected patients who were not exposed to INSTI. Drug resistance mutations (DRMs) were detected among 1.3% of ART-naïve patients and among 2.7% of INSTI-naïve patients. The prevalence of 12 polymorphic mutations was significantly different between sub-subtypes A6 and A1. Analysis of the genetic barriers determined two positions in which subtype A (A1 and A6) showed a higher genetic barrier (G140C and V151I) compared with subtype B, and one position in which subtypes A1 and B displayed a higher genetic barrier (L74M and L74I) than sub-subtype A6. Additionally, we confirmed that the L74I mutation was selected at the early stage of the epidemic and subsequently spread as a founder effect in Russia. Our data have added to the overall understanding of the genetic features of sub-subtype A6 in the context of drug resistance. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://repub.eur.nl/pub/129477Test; urn:hdl:1765/129477 |
| DOI: | 10.3390/v12080838 |
| الإتاحة: | https://doi.org/10.3390/v12080838Test http://repub.eur.nl/pub/129477Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.898F1C57 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/v12080838 |
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