دورية أكاديمية
Genetically low vitamin D concentrations and myopic refractive error: A Mendelian randomization study
| العنوان: | Genetically low vitamin D concentrations and myopic refractive error: A Mendelian randomization study |
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| المؤلفون: | Cuellar-Partida, G. (Gabriel), Williams, K.M. (Katie M.), Yazar, S. (Seyhan), Guggenheim, J. (Jean), Hewitt, A.W. (Alex W.), Williams, C. (Cathy), JinWang, J. (Jie), Kho, P.-F. (Pik-Fang), Saw, S-M. (Seang-Mei), Cheng, C-Y. (Ching-Yu), YinWong, T. (Tien), Aung, T. (Tin), LYoung, T. (Terri), Tideman, J.W.L. (Willem), Jonas, J.B. (Jost B.), Mitchell, P. (Paul), Wojciechowski, R. (Robert), Stambolian, D.E. (Dwight), Hysi, P.G. (Pirro), Hammond, C.J. (Christopher), Mackey, D.A. (David), Lucas, R.M. (Robyn M.), MacGregor, S. (Stuart) |
| المصدر: | International Journal of Epidemiology vol. 46 no. 6, pp. 1882-1890 |
| سنة النشر: | 2017 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: | Mendelian randomization, Myopia, Vitamin D |
| الوصف: | Background: Myopia prevalence has increased in the past 20 years, with many studies linking the increase to reduced time spent outdoors. A number of recent observational studies have shown an inverse association between vitamin D [25(OH)D] serum levels and myopia. However, in such studies it is difficult to separate the effects of time outdoors and vitamin D levels. In this work we use Mendelian randomization (MR) to assess if genetically determined 25(OH)D levels contribute to the degree of myopia. Methods: We performed MR using results from a meta-analysis of refractive error (RE) genome-wide association study (GWAS) that included 37 382 and 8 376 adult participants of European and Asian ancestry, respectively, published by the Consortium for Refractive Error And Myopia (CREAM). We used single nucleotide polymorphisms (SNPs) in |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://repub.eur.nl/pub/108251Test; urn:hdl:1765/108251 |
| DOI: | 10.1093/ije/dyx068 |
| الإتاحة: | https://doi.org/10.1093/ije/dyx068Test http://repub.eur.nl/pub/108251Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.942B9357 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ije/dyx068 |
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