دورية أكاديمية
Vaccination with nanoparticles displaying gH/gL from Epstein-Barr virus elicits limited cross-protection against rhesus lymphocryptovirus.
| العنوان: | Vaccination with nanoparticles displaying gH/gL from Epstein-Barr virus elicits limited cross-protection against rhesus lymphocryptovirus. |
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| المؤلفون: | Edwards, Kristina R, Schmidt, Karina, Homad, Leah J, Kher, Gargi M, Xu, Guoyue, Rodrigues, Kristen A, Ben-Akiva, Elana, Abbott, Joe, Prlic, Martin, Newell, Evan W, De Rosa, Stephen C, Irvine, Darrell J, Pancera, Marie, McGuire, Andrew T |
| المصدر: | Cell Rep Med ; ISSN:2666-3791 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Epstein-Barr virus, adjuvants, challenge studies, nanoparticles, neutralizing antibodies, rhesus lymphocryptovirus, vaccines |
| الوصف: | Epstein-Barr virus (EBV) is associated with infectious mononucleosis, cancer, and multiple sclerosis. A vaccine that prevents infection and/or EBV-associated morbidity is an unmet need. The viral gH/gL glycoprotein complex is essential for infectivity, making it an attractive vaccine target. Here, we evaluate the immunogenicity of a gH/gL nanoparticle vaccine adjuvanted with the Sigma Adjuvant System (SAS) or a saponin/monophosphoryl lipid A nanoparticle (SMNP) in rhesus macaques. Formulation with SMNP elicits higher titers of neutralizing antibodies and more vaccine-specific CD4+ T cells. All but one animal in the SMNP group were infected after oral challenge with the EBV ortholog rhesus lymphocryptovirus (rhLCV). Their immune plasma had a 10- to 100-fold lower reactivity against rhLCV gH/gL compared to EBV gH/gL. Anti-EBV neutralizing monoclonal antibodies showed reduced binding to rhLCV gH/gL, demonstrating that EBV gH/gL neutralizing epitopes are poorly conserved on rhLCV gH/gL. Prevention of rhLCV infection despite antigenic disparity supports clinical development of gH/gL nanoparticle vaccines against EBV. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.xcrm.2024.101587Test; https://pubmed.ncbi.nlm.nih.gov/38781964Test |
| DOI: | 10.1016/j.xcrm.2024.101587 |
| الإتاحة: | https://doi.org/10.1016/j.xcrm.2024.101587Test https://pubmed.ncbi.nlm.nih.gov/38781964Test |
| حقوق: | Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved. |
| رقم الانضمام: | edsbas.375E608C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.xcrm.2024.101587 |
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