المؤلفون: Lei Liu, Jason Long, Ingrid C. Rulifson, Brad Herberich, Miki Hardy, Oliver Homann, Monica Florio, Mei-Chu Lo, Jerry Ryan Holder, Shivani Singh, Hui Dou, Michael Ollmann, Elissa Swearingen, Danielle Pruitt, Kelvin K. C. Sham, Bin Wu, Justin K. Murray, Artem Shkumatov

المصدر: Nucleic Acid Therapeutics. 31:324-340

مصطلحات موضوعية: Single-nucleotide polymorphism, Biology, Biochemistry, Mice, Non-alcoholic Fatty Liver Disease, Drug Discovery, Nonalcoholic fatty liver disease, Genetics, medicine, Animals, SNP, RNA, Small Interfering, Molecular Biology, Gene, Alleles, Genetic association, Membrane Proteins, food and beverages, Lipase, medicine.disease, Minor allele frequency, Liver, Patatin-like phospholipase, Phospholipases A2, Calcium-Independent, Molecular Medicine, Human genome, Genome-Wide Association Study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2000bde8307608b78ff279a1e4c61bTest
https://doi.org/10.1089/nat.2021.0026Test

المؤلفون: Brad Herberich, Thomas Nixey, Lin Yin, Tayo Ikotun, Kelvin K. C. Sham, Jason Long, Hongyan Li, Charles Glaus, Xuhai Be, Les P. Miranda, Yuan Cheng, Marcus Soto, James R. Falsey, Bryan D. Moyer, Robert S. Foti, Christopher M. Tegley, Chawita Netirojjanakul, Linh Tran, Kip P. Conner, Jennifer Aral, Liyue Huang, Kaustav Biswas, Justin K. Murray, Bin Wu, Loren Berry, Dean Hickman, Dan A. Rock

المصدر: Drug Metabolism and Disposition. 47:1111-1121

مصطلحات موضوعية: Male, Immunoconjugates, Metabolic Clearance Rate, In silico, Drug Evaluation, Preclinical, Pharmaceutical Science, Peptide, Receptors, Fc, Mice, Neonatal Fc receptor, In vivo, medicine, Animals, Tissue Distribution, Receptor, Cryopreservation, Mice, Knockout, Voltage-Gated Sodium Channel Blockers, Pharmacology, chemistry.chemical_classification, Drug discovery, Histocompatibility Antigens Class I, NAV1.7 Voltage-Gated Sodium Channel, Antibodies, Monoclonal, In vitro, Macaca fascicularis, medicine.anatomical_structure, Biochemistry, chemistry, Hepatocyte, Hepatocytes, Administration, Intravenous, Chronic Pain, Peptides

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aafa704103c2cd45fe6f198cffc5d5fTest
https://doi.org/10.1124/dmd.119.087742Test

المؤلفون: Sara C. Humphreys, Brooke M. Rock, Kelvin K. C. Sham, Richard Smith, Xin Huang, Bin Wu, Yue Hao, Babak Basiri, Mai B. Thayer, Julie M. Lade

المصدر: Drug Metabolism and Disposition. 47:1174-1182

مصطلحات موضوعية: Pharmacology, Small interfering RNA, Oligonucleotide, Pharmaceutical Science, RNA, Plasma protein binding, 030226 pharmacology & pharmacy, Blood proteins, N-Acetylgalactosamine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Biochemistry, chemistry, Free fraction, 030220 oncology & carcinogenesis, Ribose

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a2753653687a4c1993209b87a72d5593Test
https://doi.org/10.1124/dmd.119.086967Test

المؤلفون: Artaches A. Kazarian, Jeremy Cabrera, Jason Long, Kelvin K. C. Sham, Justin K. Murray, Iain D. G. Campuzano, Theodore Fitch, Wesley W. Barnhart, Bin Wu

المصدر: Journal of chromatography. A. 1634

مصطلحات موضوعية: Oligonucleotide Purification, Monolithic HPLC column, Chromatography, Ion exchange, Oligonucleotide, Chemistry, Organic Chemistry, Oligonucleotides, General Medicine, Mass spectrometry, Chromatography, Ion Exchange, Biochemistry, Chemistry Techniques, Analytical, Mass Spectrometry, Analytical Chemistry, G-Quadruplexes, Native state, heterocyclic compounds, Amine gas treating, Protein secondary structure

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9d23c25c4103c134a8add9d6aca008Test
https://pubmed.ncbi.nlm.nih.gov/33189959Test

المؤلفون: John B. Jordan, Justin K. Murray, Kristin L. Andrews, Licheng Shi, Philippe Favreau, Ruoyuan Yin, Violeta Yu, Josie H. Lee, Kelvin K. C. Sham, Bin Wu, Kaustav Biswas, Dong Liu, Anruo Zou, Joseph Ligutti, Jason Long, Les P. Miranda, Bryan D. Moyer, Reto Stöcklin

المصدر: PLoS ONE, Vol 13, Iss 5, p e0196791 (2018)
PLoS ONE

مصطلحات موضوعية: Male, 0301 basic medicine, Science and Technology Workforce, Patch-Clamp Techniques, Physiology, Drug Evaluation, Preclinical, Action Potentials, Spider Venoms, lcsh:Medicine, Peptide, Toxicology, Pathology and Laboratory Medicine, Careers in Research, Protein Engineering, Nerve Fibers, Animal Cells, Ganglia, Spinal, Medicine and Health Sciences, Toxins, Macromolecular Engineering, lcsh:Science, Neurons, chemistry.chemical_classification, Analgesics, Multidisciplinary, Peptide analog, biology, Chemistry, NAV1.7 Voltage-Gated Sodium Channel, Recombinant Proteins, Cell biology, Peptide Conformation, Electrophysiology, Professions, Engineering and Technology, Synthetic Biology, Cellular Types, Research Article, Biotechnology, Sodium Channel Blockers, Cell Binding, Cell Physiology, Science Policy, Toxic Agents, Neurophysiology, Bioengineering, Tetrodotoxin, Inhibitory postsynaptic potential, Membrane Potential, Cell Line, Chilobrachys jingzhao, Structure-Activity Relationship, 03 medical and health sciences, Physical Stimulation, Animals, Humans, Patch clamp, Binding site, Nuclear Magnetic Resonance, Biomolecular, Nerve Fibers, Unmyelinated, Venoms, Sodium channel, lcsh:R, Biology and Life Sciences, Engineers, Cell Biology, biology.organism_classification, Mice, Inbred C57BL, 030104 developmental biology, Amino Acid Substitution, Synthetic Bioengineering, Cellular Neuroscience, People and Places, Mutagenesis, Site-Directed, Population Groupings, lcsh:Q, Capsaicin, Peptides, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59eb0148307a9c0a0a9fe2b23d52da70Test
http://europepmc.org/articles/PMC5933747?pdf=renderTest

المؤلفون: Andrew Tasker, Andrea Itano, Anu Gore, Paul E. Harrington, Mike Frohn, Victor J. Cee, Michele McElvain, Min Wong, Mike Fiorino, Alexander J. Pickrell, Kelvin K. C. Sham, Han Xu, Brian A. Lanman, Anthony B. Reed, Yang Xu, Susana C. Neira, Scot Middleton, Henry Morrison

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1779-1783

مصطلحات موضوعية: Agonist, Gene isoform, Oral dose, Pyridines, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Carboxylic Acids, Administration, Oral, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, chemistry.chemical_compound, Pharmacokinetics, In vivo, Drug Discovery, Pyridine, medicine, Animals, Protein Isoforms, Carboxylate, Amines, Molecular Biology, Molecular Structure, Organic Chemistry, Rats, Blood lymphocyte, Receptors, Lysosphingolipid, Thiazoles, chemistry, Cyclization, Rats, Inbred Lew, Molecular Medicine, Female, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f3cc5bea5e6a249ac305b5230ca5f2Test
https://doi.org/10.1016/j.bmcl.2011.12.073Test

المؤلفون: Kelvin K. C. Sham, Lewis D. Pennington, Paul E. Harrington, Matthew R. Lee, Michele McElvain, Xuxia Zhang, Heather A. Arnett, Min Wong, Alexander J. Pickrell, Anthony B. Reed, Henry Morrison, Victor J. Cee, Mike Fiorino, Christopher H. Fotsch, Michael J. Frohn, Yang Xu, Michael Croghan, Han Xu, Brian A. Lanman, Andrew Tasker, Michelle Horner

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:527-531

مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, In vitro, Pharmacokinetics, In vivo, Pharmacodynamics, Drug Discovery, medicine, Molecular Medicine, Potency, Structure–activity relationship, Selectivity, Molecular Biology, Nuclear chemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5e9317f7724366d80a0b866a4ab4fecaTest
https://doi.org/10.1016/j.bmcl.2011.10.085Test

المؤلفون: Michael Croghan, Andrew Tasker, Matthew R. Lee, Xuxia Zhang, Heather A. Arnett, Victor J. Cee, Anthony B. Reed, Kelvin K. C. Sham, Michele McElvain, Henry Morrison, Alexander J. Pickrell, Lewis D. Pennington, Mike Frohn, Yang Xu, Paul E. Harrington, Min Wong, Han Xu, Brian A. Lanman, Mike Fiorino, Christopher H. Fotsch

المصدر: ACS Medicinal Chemistry Letters. 3:74-78

مصطلحات موضوعية: Agonist, Orally active, Pharmacokinetics, business.industry, medicine.drug_class, Organic Chemistry, Drug Discovery, Medicine, Pharmacology, business, Biochemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513454b43d7abc3801057fdc295f1e0aTest
https://doi.org/10.1021/ml200252bTest

المؤلفون: Min Wong, Heather A. Arnett, Michael Croghan, Michele McElvain, Yang Xu, Xuxia Zhang, Matthew R. Lee, Lewis D. Pennington, Paul E. Harrington, Henry Morrison, Victor J. Cee, Anthony B. Reed, Michael J. Frohn, Alexander J. Pickrell, Mike Fiorino, Kelvin K. C. Sham, Han Xu, Brian A. Lanman, Christopher H. Fotsch, Michelle Horner

المصدر: ACS Medicinal Chemistry Letters. 2:752-757

مصطلحات موضوعية: Agonist, Trifluoromethyl, Nicotinamide, medicine.drug_class, business.industry, Lymphocyte, Organic Chemistry, Pharmacology, Biochemistry, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Drug Discovery, medicine, Potency, business, Receptor, Selectivity, EC50

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888681fe352e70d553e6a823a8d63a57Test
https://doi.org/10.1021/ml2001399Test

المؤلفون: Alexander J. Pickrell, Tisha San Miguel, Kelvin K. C. Sham, Christopher H. Fotsch, Andreas Reichelt, Leeanne Zalameda, Matthew P. Bourbeau, Aaron C. Siegmund, John G. Allen, Heller Scott Francis, Sonia Escobar, Julie M. Bailis, Paul E. Harrington, Tammy L. Bush, Jessica Orf, Helming Tan, Faye Hsieh, Michael J. Frohn, Minqing Rong, Dean Hickman

المصدر: Bioorganicmedicinal chemistry letters. 23(23)

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Mice, Nude, Cell Cycle Proteins, Pharmacology, Protein Serine-Threonine Kinases, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, Animals, Isoquinoline, Molecular Biology, IC50, Cell potency, Protein Kinase Inhibitors, Oxadiazoles, Molecular Structure, Kinase, Organic Chemistry, Glutathione, Xenograft Model Antitumor Assays, Rats, Disease Models, Animal, chemistry, Pharmacodynamics, Molecular Medicine, Female, Selectivity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80b8cef2633298909e4ec8b28a43c14Test
https://pubmed.ncbi.nlm.nih.gov/24120542Test