دورية أكاديمية
A Case of Progressive Bleomycin Lung Toxicity Refractory to Steroid Therapy
| العنوان: | A Case of Progressive Bleomycin Lung Toxicity Refractory to Steroid Therapy |
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| المؤلفون: | Christopher S Dossett MD, Kelli Kosako Yost MD, Christopher Lau MD, Nafis Shamsid-Deen MD |
| المصدر: | Southwest Journal of Pulmonary and Critical Care, Vol 26, Iss 6, Pp 90-96 (2023) |
| بيانات النشر: | Arizona Thoracic Society, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:General works LCC:Medical emergencies. Critical care. Intensive care. First aid |
| مصطلحات موضوعية: | bleomycin, pulmonary fibrosis, treatment, pulmonary function tests, corticosteroids, ct scan, etoposide, case presentation, bleomycin-induced lung injury, bleomycin pulmonary toxicity, General works, R5-130.5, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| الوصف: | Bleomycin is a common chemotherapy agent used to treat germinative tumors. Bleomycin-induced lung injury (BILI) is an uncommon but devastating adverse effect of its use. It occurs in 10-20% of patients receiving bleomycin, and the initial diagnosis is usually made by new-onset respiratory symptoms and reduced diffusing capacity for carbon monoxide (DLCO). Mainstay treatment includes discontinuing bleomycin, corticosteroids, and supplemental oxygen if needed. We present a case of a 38-year-old male who was found to have a severe presentation of bleomycin-induced lung injury after chemotherapy for metastatic mixed germ cell testicular cancer. During his course, he was treated with the standard of care regimen of corticosteroids and salvage therapy with infliximab but ultimately died from complications of his illness. This case report is noteworthy because our patient had progressive bleomycin-induced lung injury, despite discontinuing bleomycin many months prior, consistent high-dose corticosteroid treatment, and even salvage therapy. In all patients on bleomycin, pulmonary function monitoring is essential, and any complaints of dyspnea should prompt concern for bleomycin-induced lung injury. If initial treatment does not improve their condition, more aggressive measures may be necessary. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2160-6773 |
| العلاقة: | https://www.swjpcc.com/pulmonary/2023/6/10/a-case-of-progressive-bleomycin-lung-toxicity-refractory-to.htmlTest; https://doaj.org/toc/2160-6773Test |
| DOI: | 10.13175/swjpccs013-23 |
| الوصول الحر: | https://doaj.org/article/57b658f4ac864510a431942ee795735eTest |
| رقم الانضمام: | edsdoj.57b658f4ac864510a431942ee795735e |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 21606773 |
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| DOI: | 10.13175/swjpccs013-23 |