Conversion surgery for initially unresectable biliary malignancies: a multicenter retrospective cohort study
| العنوان: | Conversion surgery for initially unresectable biliary malignancies: a multicenter retrospective cohort study |
|---|---|
| المؤلفون: | Minoru Nagayama, Masafumi Imamura, Koji Imai, Masaki Kuwatani, Yasuyuki Kawamoto, Yastoshi Kimura, Satoshi Hirano, Keikuke Okamura, Takehiro Noji |
| المصدر: | Surgery Today. 50:1409-1417 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Cohort Studies, Biliary malignancy, Surgical oncology, Preoperative Care, medicine, Humans, Preoperative chemotherapy, Tumor location, Survival rate, Aged, Retrospective Studies, Aged, 80 and over, Chemotherapy, business.industry, Retrospective cohort study, Chemoradiotherapy, Adjuvant, General Medicine, Middle Aged, Surgery, Survival Rate, Biliary Tract Neoplasms, Treatment Outcome, Feasibility Studies, Female, business, Median survival |
| الوصف: | Few studies have focused on conversion surgery for biliary malignancy; thus, it is not clear if this treatment modality can extend the survival of patients with unresectable biliary malignancy. We conducted a multicenter retrospective cohort study to evaluate the surgical outcomes of conversion surgery in this setting and analyze long-term survival. We collected clinical data retrospectively on patients who underwent conversion surgery for biliary malignancy. Twenty-four patients met our inclusion criteria. Preoperative chemotherapy regimens or chemoradiation therapy regimens were administered based on the institutional criteria, and surgical procedures were chosen based on tumor location. Morbidity occurred in 16 patients (66.7%), and 1 patient died of liver failure after surgery. The overall 5-year survival rate following initial therapy was 43.2%, and the median survival time was 57.4 months. The corresponding values following surgery were 38.2% and 34.3 months, respectively. The 5-year survival rate of the 24 patients who received both chemotherapy and surgery was significantly better than that of 110 patients treated with chemotherapy only (p |
| تدمد: | 1436-2813 0941-1291 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113c6e6c10bacf7dc58c09ca55470de0Test https://doi.org/10.1007/s00595-020-02031-5Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....113c6e6c10bacf7dc58c09ca55470de0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14362813 09411291 |
|---|