المؤلفون: Bielecki, Piotr, Riesenfeld, Samantha J, Hütter, Jan-Christian, Torlai Triglia, Elena, Kowalczyk, Monika S, Ricardo-Gonzalez, Roberto R, Lian, Mi, Amezcua Vesely, Maria C, Kroehling, Lina, Xu, Hao, Slyper, Michal, Muus, Christoph, Ludwig, Leif S, Christian, Elena, Tao, Liming, Kedaigle, Amanda J, Steach, Holly R, York, Autumn G, Skadow, Mathias H, Yaghoubi, Parastou, Dionne, Danielle, Jarret, Abigail, McGee, Heather M, Porter, Caroline BM, Licona-Limón, Paula, Bailis, Will, Jackson, Ruaidhrí, Gagliani, Nicola, Gasteiger, Georg, Locksley, Richard M, Regev, Aviv, Flavell, Richard A

المصدر: Nature. 592(7852)

مصطلحات موضوعية: Genetics, Emerging Infectious Diseases, Psoriasis, Autoimmune Disease, Aetiology, 2.1 Biological and endogenous factors, Underpinning research, 1.1 Normal biological development and functioning, Inflammatory and immune system, Skin, Animals, Cell Differentiation, Cell Lineage, Chromatin, Disease Models, Animal, Female, Immunity, Innate, Inflammation, Interleukin-23, Latent Class Analysis, Lymphocytes, Male, Mice, RNA, Small Cytoplasmic, Reproducibility of Results, Time Factors, General Science & Technology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4cc9s2xzTest

المؤلفون: Kedaigle, Amanda Joy

مرشدي الرسالة: Ernest Fraenkel., Massachusetts Institute of Technology. Computational and Systems Biology Program.

مصطلحات موضوعية: Computational and Systems Biology Program.

وصف الملف: 315 pages; application/pdf

الإتاحة: http://hdl.handle.net/1721.1/119026Test

المؤلفون: Kedaigle, Amanda J, Fraenkel, Ernest, Atwal, Ranjit S, Wu, Min, Gusella, James F, MacDonald, Marcy E, Kaye, Julia A, Finkbeiner, Steven, Mattis, Virginia B, Tom, Colton M, Svendsen, Clive, King, Alvin R, Chen, Yumay, Stocksdale, Jennifer T, Lim, Ryan G, Casale, Malcolm, Wang, Ping H, Thompson, Leslie M, Akimov, Sergey S, Ratovitski, Tamara, Arbez, Nicolas, Ross, Christopher A

المصدر: Human Molecular Genetics. 29(11)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Neurosciences, Huntington's Disease, Stem Cell Research, Brain Disorders, Regenerative Medicine, Neurodegenerative, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Neurological, Adenosine Triphosphate, Cell Differentiation, Cell Line, Corpus Striatum, Energy Metabolism, Glycolysis, Humans, Huntington Disease, Induced Pluripotent Stem Cells, Metabolome, Mitochondria, Neurons, Oxidative Phosphorylation, HD iPSC Consortium, Medical and Health Sciences, Genetics & Heredity, Genetics

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9h03m40rTest

المؤلفون: Kedaigle, Amanda J, Reidling, Jack C, Lim, Ryan G, Adam, Miriam, Wu, Jie, Wassie, Brook, Stocksdale, Jennifer T, Casale, Malcolm S, Fraenkel, Ernest, Thompson, Leslie M

المصدر: Human Molecular Genetics. 29(2)

مصطلحات موضوعية: Biological Sciences, Genetics, Brain Disorders, Neurosciences, Human Genome, Rare Diseases, Huntington's Disease, Neurodegenerative, 2.1 Biological and endogenous factors, Aetiology, Neurological, Acetylation, Animals, Azepines, Behavior Rating Scale, Behavioral Symptoms, Cerebral Cortex, Chromatin Immunoprecipitation Sequencing, Corpus Striatum, Disease Models, Animal, Energy Metabolism, Epigenesis, Genetic, Gene Expression Regulation, Gene Ontology, Histones, Huntingtin Protein, Huntington Disease, Male, Mice, Mice, Transgenic, Motor Activity, Protein Biosynthesis, RNA-Seq, Signal Transduction, Triazoles, Medical and Health Sciences, Genetics & Heredity

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/0p42w8z5Test

المؤلفون: Paulsen, Bruna, Velasco, Silvia, Kedaigle, Amanda J, Pigoni, Martina, Quadrato, Giorgia, Deo, Anthony J, Adiconis, Xian, Uzquiano, Ana, Sartore, Rafaela, Yang, Sung Min, Simmons, Sean K, Symvoulidis, Panagiotis, Kim, Kwanho, Tsafou, Kalliopi, Podury, Archana, Abbate, Catherine, Tucewicz, Ashley, Smith, Samantha N, Albanese, Alexandre, Barrett, Lindy, Sanjana, Neville E, Shi, Xi, Chung, Kwanghun, Lage, Kasper, Boyden, Edward S, Regev, Aviv, Levin, Joshua Z, Arlotta, Paola

المساهمون: Massachusetts Institute of Technology. Department of Biology

المصدر: PMC

وصف الملف: application/pdf

العلاقة: Nature; https://hdl.handle.net/1721.1/147065Test; Paulsen, Bruna, Velasco, Silvia, Kedaigle, Amanda J, Pigoni, Martina, Quadrato, Giorgia et al. 2022. "Autism genes converge on asynchronous development of shared neuron classes." Nature, 602 (7896).

الإتاحة: https://hdl.handle.net/1721.1/147065Test

المؤلفون: Lim, Ryan G, Quan, Chris, Reyes-Ortiz, Andrea M, Lutz, Sarah E, Kedaigle, Amanda J, Gipson, Theresa A, Wu, Jie, Vatine, Gad D, Stocksdale, Jennifer, Casale, Malcolm S, Svendsen, Clive N, Fraenkel, Ernest, Housman, David E, Agalliu, Dritan, Thompson, Leslie M

المصدر: Cell Reports. 19(7)

مصطلحات موضوعية: Biological Sciences, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Neurosciences, Huntington's Disease, Rare Diseases, Stem Cell Research - Nonembryonic - Human, Stem Cell Research - Induced Pluripotent Stem Cell, Stem Cell Research, Orphan Drug, Brain Disorders, Neurodegenerative, 2.1 Biological and endogenous factors, Aetiology, Neurological, Blood-Brain Barrier, Endothelial Cells, Gene Regulatory Networks, Humans, Huntington Disease, Induced Pluripotent Stem Cells, Microvessels, Neovascularization, Physiologic, Transcriptome, Transcytosis, Wnt Signaling Pathway, beta Catenin, BMEC, Huntington’s disease, RNA sequencing, WNT signaling, angiogenesis, blood-brain barrier, brain microvascular endothelial cell, epigenetics, induced pluripotent stem cell, neurodegeneration, transcriptome, Biochemistry and Cell Biology, Medical Physiology, Biological sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6z1351tfTest

المؤلفون: Lim, Ryan G, Salazar, Lisa L, Wilton, Daniel K, King, Alvin R, Stocksdale, Jennifer T, Sharifabad, Delaram, Lau, Alice L, Stevens, Beth, Reidling, Jack C, Winokur, Sara T, Casale, Malcolm S, Thompson, Leslie M, Pardo, Monica, Gerardo Garcia Diaz-Barriga, A, Straccia, Marco, Sanders, Phil, Alberch, Jordi, Canals, Josep M, Kaye, Julia A, Dunlap, Mariah, Jo, Lisa, May, Hanna, Mount, Elliot, Anderson-Bergman, Cliff, Haston, Kelly, Finkbeiner, Steven, Kedaigle, Amanda J, Gipson, Theresa A, Yildirim, Ferah, Ng, Christopher W, Milani, Pamela, Housman, David E, Fraenkel, Ernest, Allen, Nicholas D, Kemp, Paul J, Atwal, Ranjit Singh, Biagioli, Marta, Gusella, James F, MacDonald, Marcy E, Akimov, Sergey S, Arbez, Nicolas, Stewart, Jacqueline, Ross, Christopher A, Mattis, Virginia B, Tom, Colton M, Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Svendsen, Clive N

المصدر: Nature Neuroscience. 20(5)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Neurosciences, Rare Diseases, Regenerative Medicine, Brain Disorders, Neurodegenerative, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Huntington's Disease, Stem Cell Research - Nonembryonic - Human, Stem Cell Research, Stem Cell Research - Induced Pluripotent Stem Cell, Aetiology, 2.1 Biological and endogenous factors, Neurological, Animals, Basic Helix-Loop-Helix Transcription Factors, Cells, Cultured, Cognitive Dysfunction, Corpus Striatum, Epigenomics, Gene Expression, Gene Expression Profiling, Gene Knockdown Techniques, Histones, Humans, Huntingtin Protein, Huntington Disease, Induced Pluripotent Stem Cells, Isoxazoles, Mice, Mice, Transgenic, Nerve Tissue Proteins, Neurogenesis, Neurons, Peptides, Signal Transduction, Thiophenes, HD iPSC Consortium, Psychology, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/0b73w87pTest

المؤلفون: Uzquiano, Ana, Kedaigle, Amanda J., Pigoni, Martina, Paulsen, Bruna, Adiconis, Xian, Kim, Kwanho, Faits, Tyler, Nagaraja, Surya, Antón-Bolaños, Noelia, Gerhardinger, Chiara, Tucewicz, Ashley, Murray, Evan, Jin, Xin, Buenrostro, Jason, Chen, Fei, Velasco, Silvia, Regev, Aviv, Levin, Joshua Z., Arlotta, Paola

المساهمون: Chan Zuckerberg Initiative, National Institutes of Health, Howard Hughes Medical Institute, Harvard University, Broad Institute Stanley Center for Psychiatric Research, Broad Institute Klarman Cell Observatory, Broad Institute

المصدر: Cell ; volume 185, issue 20, page 3770-3788.e27 ; ISSN 0092-8674

الإتاحة: https://doi.org/10.1016/j.cell.2022.09.010Test
https://api.elsevier.com/content/article/PII:S0092867422011680?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0092867422011680?httpAccept=text/plainTest

المؤلفون: Akimov, Sergey S, Jiang, Mali, Kedaigle, Amanda Joy, Arbez, Nicolas, Marque, Leonard O, Eddings, Chelsy R, Ranum, Paul T, Whelan, Emma, Tang, Anthony, Wang, Ronald, DeVine, Lauren R, Talbot, Conover C, Cole, Robert N, Ratovitski, Tamara, Davidson, Beverly L, Fraenkel, Ernest, Ross, Christopher A

المساهمون: Massachusetts Institute of Technology. Computational and Systems Biology Program, Massachusetts Institute of Technology. Department of Biological Engineering

المصدر: Prof. Fraenkel

وصف الملف: application/pdf

العلاقة: http://dx.doi.org/10.1093/hmg/ddab200Test; Human Molecular Genetics; https://hdl.handle.net/1721.1/131267Test; Akimov, Sergey S. et al. "Immortalized striatal precursor neurons from Huntington’s disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics." Human Molecular Genetics (July 2021): ddab200.

الإتاحة: https://doi.org/10.1093/hmg/ddab200Test
https://hdl.handle.net/1721.1/131267Test

المؤلفون: Kedaigle, Amanda Joy, Fraenkel, Ernest

المساهمون: Massachusetts Institute of Technology. Computational and Systems Biology Program, Massachusetts Institute of Technology. Dept. of Biological Engineering.

المصدر: PMC

وصف الملف: application/octet-stream

العلاقة: Methods Mol Biol; https://hdl.handle.net/1721.1/133259.2Test

الإتاحة: https://hdl.handle.net/1721.1/133259.2Test