التفاصيل البيبلوغرافية
| العنوان: |
Convincing Catalytic Performance of Oxo-Tethered Ruthenium Complexes for Asymmetric Transfer Hydrogenation of Cyclic α‑Halogenated Ketones through Dynamic Kinetic Resolution |
| المؤلفون: |
Taichiro Touge (2166319), Hideki Nara (2166316), Michio Kida (4397026), Kazuhiko Matsumura (2181620), Yoshihito Kayaki (1600162) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Genetics, Biotechnology, Developmental Biology, Cancer, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, transfer hydrogenation, sulfone functions, Bifunctional, ee, Halogenated, dopamine D 3 receptor ligand, oxo-tethered, diastereo, cyclic halohydrins, chiral alcohols, halogen, approach, enantioselectivitie, ester, variably, Cyclic, d.r, Dynamic Kinetic Resolution, Asymmetric Transfer Hydrogenation, Ketone, catalyst |
| الوصف: |
A highly efficient dynamic kinetic resolution of cyclic halohydrins was achieved by the asymmetric transfer hydrogenation of racemic α-haloketones. Bifunctional oxo-tethered Ru(II) catalysts could promote the reduction without deterioration of halogens. By structural tuning of the catalyst, chiral alcohols having halogen, ester, carboxamide, and sulfone functions were obtained variably with excellent diastereo- and enantioselectivities (up to >99:1 d.r. and >99.9 ee), which provided a concise synthetic approach to a dopamine D3 receptor ligand, (+)-PHNO. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Convincing_Catalytic_Performance_of_Oxo-Tethered_Ruthenium_Complexes_for_Asymmetric_Transfer_Hydrogenation_of_Cyclic_Halogenated_Ketones_through_Dynamic_Kinetic_Resolution/14333972Test |
| DOI: |
10.1021/acs.orglett.1c00739.s001 |
| الإتاحة: |
https://doi.org/10.1021/acs.orglett.1c00739.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.2540CDA1 |
| قاعدة البيانات: |
BASE |
