دورية أكاديمية
Effect of hypoxia-inducible factor-1 alpha expression on survival in patients with metastatic cervical squamous cell carcinoma treated with first-line chemotherapy and bevacizumab
| العنوان: | Effect of hypoxia-inducible factor-1 alpha expression on survival in patients with metastatic cervical squamous cell carcinoma treated with first-line chemotherapy and bevacizumab |
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| المؤلفون: | Yildirim, Hasan Cagri, Anik, Hicran, Ozdemir, Deniz Ates, Ismayilov, Rashad, Akyildiz, Arif, Cayiroz, Kerim, Ceyhan, Fahri, Kavruk, Oguzalp, Guven, Deniz Can, Ates, Ozturk, Usubutun, Alp, Arik, Zafer |
| المصدر: | Biomolecules and Biomedicine; Advanced online ; 2831-090X ; 2831-0896 |
| بيانات النشر: | Association of Basic Medical Sciences of FBIH |
| سنة النشر: | 2024 |
| المجموعة: | Bosnian Journal of Basic Medical Sciences (BJBMS) |
| مصطلحات موضوعية: | Metastatic cervical cancer, squamous cell carcinoma (SCC), vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1 alpha (HIF-1 alpha), bevacizumab |
| الوصف: | This study addresses the gap in understanding the prognostic relevance of hypoxia-inducible factor-1 alpha (HIF-1 alpha) expression in metastatic cervical squamous cell carcinoma (SCC) patients undergoing anti-vascular endothelial growth factor (VEGF)-based therapy. A retrospective multicenter study (n = 34) explored HIF-1 alpha expression via immunohistochemistry in patients treated with platinum chemotherapy and bevacizumab. Median progression-free survival (PFS) was significantly lower in the HIF-1 alpha low score group compared to the high score group (4.9 vs 12.9 months, P = 0.014). Similarly, the median overall survival (OS) was significantly reduced in the HIF-1 alpha low score group (8.3 vs 20.4 months, P = 0.006). This study, the first of its kind, highlights the prognostic significance of HIF-1 alpha expression in metastatic cervical SCC patients treated with bevacizumab-based therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/10255/3202Test; https://www.bjbms.org/ojs/index.php/bjbms/article/view/10255Test |
| DOI: | 10.17305/bb.2024.10255 |
| الإتاحة: | https://doi.org/10.17305/bb.2024.10255Test https://www.bjbms.org/ojs/index.php/bjbms/article/view/10255Test |
| حقوق: | Copyright (c) 2024 Hasan Cagri Yildirim, Hicran Anik, Deniz Ates Ozdemir, Rashad Ismayilov, Arif Akyildiz, Kerim Cayiroz, Fahri Ceyhan, Oguzalp Kavruk, Deniz Can Guven, Ozturk Ates, Alp Usubutun, Zafer Arik ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.1E77C8C8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17305/bb.2024.10255 |
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