BβArg448Lys polymorphism is associated with altered fibrin clot structure and fibrinolysis in type 2 diabetes
| العنوان: | BβArg448Lys polymorphism is associated with altered fibrin clot structure and fibrinolysis in type 2 diabetes |
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| المؤلفون: | Jackie F. Price, Kristina F. Standeven, Mark W. J. Strachan, Katie A. Greenhalgh, Paul D. Baxter, Robert F. Storey, Robert A. S. Ariëns, Ramzi A. Ajjan, Peter J. Grant, S. H. Alzahrani |
| المصدر: | Greenhalgh, KA, Strachan, M W, Alzahrani, S H, Baxter, P D, Standeven, KF, Storey, R F, Ariens, R A S, Grant, P J, Price, J & Ajjan, R A 2017, ' BβArg448Lys polymorphism is associated with altered fibrin clot structure and fibrinolysis in type 2 diabetes ', Thrombosis and Haemostasis, vol. 117, no. 2, pp. 295-302 . https://doi.org/10.1160/TH16-07-0554Test |
| بيانات النشر: | Georg Thieme Verlag KG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Protein Conformation, medicine.medical_treatment, Type 2 diabetes, 030204 cardiovascular system & hematology, Fibrinogen, DISEASE, MELLITUS, Diabetes mellitus, 0302 clinical medicine, Risk Factors, Antithrombotic, genetic polymorphism, INSULIN-RESISTANCE, biology, Fibrinolysis, Hematology, Middle Aged, Thrombosis, Phenotype, Female, Blood Coagulation Tests, medicine.drug, medicine.medical_specialty, Genotype, BETA, COAGULATION, 030209 endocrinology & metabolism, Risk Assessment, Fibrin, Structure-Activity Relationship, 03 medical and health sciences, HYPERGLYCEMIA, Internal medicine, medicine, Humans, Genetic Association Studies, thrombosis, Aged, Polymorphism, Genetic, Vascular disease, business.industry, medicine.disease, Endocrinology, Diabetes Mellitus, Type 2, Scotland, MYOCARDIAL-INFARCTION, Immunology, Microscopy, Electron, Scanning, biology.protein, vascular diseases, fibrinogen, business, GLYCATION |
| الوصف: | SummaryBoth type 2 diabetes (T2DM) and Bß448Lys variant of fibrinogen are associated with dense fibrin clots, impaired fibrinolysis and increased cardiovascular risk. It was our objective to investigate whether BßArg448Lys adds to vascular risk by modulating fibrin network structure and/or fibrinolysis in diabetes. The primary aim was to study effects of BßArg448Lys on fibrin network characteristics in T2DM. Secondary aims investigated interactions between gender and BßArg448Lys substitution in relation to fibrin clot properties and vascular disease. Genotyping for BßArg448Lys and dynamic clot studies were carried out on 822 T2DM patients enrolled in the Edinburgh Type 2 Diabetes Study. Turbidimetric assays of individual plasma samples analysed fibrin clot characteristics with additional experiments conducted on clots made from purified fibrinogen, further examined by confocal and electron microscopy. Plasma clot lysis time in Bß448Lys was longer than Bß448Arg variant (mean ± SD; 763 ± 322 and 719 ± 351 seconds [s], respectively; p |
| وصف الملف: | application/pdf |
| تدمد: | 2567-689X 0340-6245 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69ba84d4efc6059af481a32796f3a32Test https://doi.org/10.1160/th16-07-0554Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a69ba84d4efc6059af481a32796f3a32 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2567689X 03406245 |
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