Clinical Evaluation of Proline, Glutamic acid, and Leucine-Rich Protein 1 Expression in Astrocytomas and Correlations with the Proliferation Marker Ki-67
| العنوان: | Clinical Evaluation of Proline, Glutamic acid, and Leucine-Rich Protein 1 Expression in Astrocytomas and Correlations with the Proliferation Marker Ki-67 |
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| المؤلفون: | Krishnamurthy Ganesh, Suresh K. Rayala, Himavani Pacharla, Roshni Saravanan, Lawrence D'Cruze, Veena Kumari Vuttaradhi, Karthika P Padmavathy, Ganesh Venkatraman, Ravishankar Pitani, D Prathiba, Akkanapally Venu |
| المصدر: | Journal of Molecular Neuroscience. 71:724-733 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Adolescent, Proline, Glutamic Acid, Astrocytoma, Biology, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Molecular marker, Humans, Proliferation Marker, Survival analysis, Aged, Aged, 80 and over, Oncogene, Brain Neoplasms, General Medicine, Glutamic acid, Middle Aged, Ki-67 Antigen, 030104 developmental biology, chemistry, Ki-67, Cancer research, biology.protein, Immunohistochemistry, Female, Neoplasm Grading, Co-Repressor Proteins, 030217 neurology & neurosurgery, Immunostaining, Transcription Factors |
| الوصف: | Malignant astrocytomas presenting in humans of any age group are a challenge to diagnose and treat. Hence, there is a quest for new markers to ascertain their grades and predict disease outcomes. Proline, glutamic acid, and leucine-rich protein 1 (PELP1), a nuclear receptor co-regulator, is an oncogene found in various cancers. We postulate that by screening for PELP1, its correlation with survival outcomes of patients across various grades can indicate a plausible novel diagnostic marker and a potential therapeutic target in gliomas. Immunostaining of 100 cases of astrocytomas for PELP1 was performed on paraffin-embedded sections. Results showed that PELP1 expression increases with higher grades; the mean H-score of PELP1 in grade-I astrocytomas was determined to be 112.3, whereas in grade-IV it was 235.1 (P value = 0.0001). Survival analysis of patients with H-score of 200-300 was only 8.8% and 68.8% in patients with scores of 0-100. PELP1 expression in high-grade astrocytomas is an important factor in determining the outcomes. Graphical abstract Evaluation of molecular expression of PELP1 along with Ki-67 LI signifies a linear increase in its expression pattern among different grades of astrocytomas from low- to high-grade tumors, which can serve as a potential prognostic molecular marker in differentiating various types of astrocytomas in humans. |
| تدمد: | 1559-1166 0895-8696 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4934c9504fc7289824c1c340a233b60Test https://doi.org/10.1007/s12031-020-01690-wTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d4934c9504fc7289824c1c340a233b60 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15591166 08958696 |
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