يعرض 1 - 10 نتائج من 21 نتيجة بحث عن '"Karin A. Kook"', وقت الاستعلام: 1.39s تنقيح النتائج
  1. 1
    Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

    المؤلفون: Alison D. Murray, Christopher M. Rubino, Helen Shiells, Charles R. Harrington, Claude M. Wischik, Hans J Moebius, Damon Wischik, Thomas C. Baddeley, Gernot Riedel, John Storey, Harish Ganesan, Peter Bentham, Roger T. Staff, Bjoern Schelter, Serge Gauthier, Vesna Vuksanović, Jianping Jia, Luc Bracoud, Karin A Kook, Christopher M. Kipps, Jiri Hardlund, Jeffrey P. Hammel

    المساهمون: Vuksanovic, Vesna [0000-0003-4655-698X], Murray, Alison D [0000-0003-4915-4847], Jia, Jianping [0000-0003-4624-0336], Kipps, Christopher M [0000-0002-5205-9712], Storey, John MD [0000-0002-5261-5467], Apollo - University of Cambridge Repository

    المصدر: Journal of Alzheimer's Disease

    مصطلحات موضوعية: 0301 basic medicine, Male, TDP-43, Gastroenterology, law.invention, 0302 clinical medicine, Randomized controlled trial, law, hydromethylthionine, education.field_of_study, leucomethylthioninium, General Neuroscience, Brain, General Medicine, Middle Aged, Magnetic Resonance Imaging, Psychiatry and Mental health, Clinical Psychology, Treatment Outcome, Frontotemporal Dementia, Disease Progression, Female, Research Article, Frontotemporal dementia, Adult, medicine.medical_specialty, Population, tau protein, 03 medical and health sciences, Atrophy, Pharmacokinetics, Behavioral variant frontotemporal dementia, Double-Blind Method, Internal medicine, medicine, Humans, education, Pathological, Aged, clinical trials, Dose-Response Relationship, Drug, business.industry, medicine.disease, Clinical trial, Methylene Blue, 030104 developmental biology, Clinical Global Impression, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2eaae9c5cf4e3236b0d7cdf4403b27Test
    https://www.repository.cam.ac.uk/handle/1810/311319Test


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  2. 2
    Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

    المؤلفون: Hans J Moebius, Charles S Davis, Jiri Hardlund, Kohkan Shamsi, Ken Marek, John Storey, Peter Bentham, Giovanni B. Frisoni, Serge Gauthier, Damon Wischik, Trevor Ahearn, Luc Bracoud, Vesna Vuksanović, Jianping Jia, Karin A Kook, Claude M. Wischik, Charles R. Harrington, Gernot Riedel, John Seibyl, Roger T. Staff, Bjoern Schelter, Gordon K. Wilcock

    المصدر: Journal of Alzheimer's Disease, Vol. 61, No 1 (2018) pp. 435-457
    Journal of Alzheimer's Disease

    مصطلحات موضوعية: Male, 0301 basic medicine, Leuco-methylthioninium, amyloid protein, International Cooperation, Treatment outcome, Disease, Cohort Studies, 0302 clinical medicine, Primary outcome, ADAS-cog, Aged, 80 and over, treatment, General Neuroscience, Low dose, clinical trial, General Medicine, Middle Aged, Mental Status and Dementia Tests, Psychiatry and Mental health, Clinical Psychology, methylthioninium, Treatment Outcome, Adas cog, Female, Alzheimer’s disease, Research Article, Antipsychotic Agents, Cohort study, medicine.medical_specialty, tau protein, 03 medical and health sciences, Double-Blind Method, Alzheimer Disease, Internal medicine, mental disorders, cohort study, medicine, Humans, Psychiatry, Aged, business.industry, Alzheimer Disease/diagnostic imaging/drug therapy, Methylene Blue, Clinical trial, 030104 developmental biology, ddc:618.97, Geriatrics and Gerontology, business, Methylene Blue/analogs & derivatives/therapeutic use, Antipsychotic Agents/therapeutic use, 030217 neurology & neurosurgery

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a2a3dd158d9089529914fba51dcc5dTest
    https://doi.org/10.3233/jad-170560Test


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  3. 3
    Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

    المؤلفون: Harish Ganesan, Christopher M. Rubino, Thomas C. Baddeley, Serge Gauthier, Peter Bentham, Vesna Vuksanović, John Storey, Karin A Kook, Roger T. Staff, Helen Shiells, Luc Bracoud, Bjoern Schelter, Claude M. Wischik, Jianping Jia, Alison D. Murray, Charles R. Harrington, Gernot Riedel, Jeffrey P. Hammel

    المصدر: Journal of Alzheimer's Disease

    مصطلحات موضوعية: Male, 0301 basic medicine, medicine.drug_class, Population, Brain Structure and Function, Pharmacology, 03 medical and health sciences, 0302 clinical medicine, Atrophy, Alzheimer Disease, population pharmacokinetics, medicine, Humans, Cognitive Dysfunction, hydromethylthionine, Cognitive decline, education, Aged, Aged, 80 and over, clinical trials, drug interaction, education.field_of_study, leucomethylthioninium, Dose-Response Relationship, Drug, business.industry, General Neuroscience, Brain, Biological activity, General Medicine, Drug interaction, medicine.disease, Methylene Blue, Clinical trial, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Acetylcholinesterase inhibitor, Female, Geriatrics and Gerontology, business, Alzheimer’s disease, 030217 neurology & neurosurgery, Research Article

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b2b0a3c02f44f9ad94069ebdc30981Test
    https://cronfa.swan.ac.uk/Record/cronfa60500/Download/60500__24688__6402ee34bd9e4be1981a4aa2425d0b8d.pdfTest


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  4. 4
    O4‐08‐02: Phase 3 Trial of the TAU Aggregation Inhibitor Leuco‐Methylthioninium‐Bis (Hydromethanesulfonate) (Lmtm) in Mild to Moderate Alzheimer's Disease

    المؤلفون: Giovanni B. Frisoni, Gordon K. Wilcock, Howard Feldman, Karin A Kook, Claude M. Wischik, Bjoern Schelter, Serge Gauthier, Lon S. Schneider, Charles R. Harrington, Damon Wischik, John Storey, Jiri Hardlund

    المصدر: Alzheimer's & Dementia. 12

    مصطلحات موضوعية: 0301 basic medicine, Leuco-methylthioninium, Epidemiology, Chemistry, Health Policy, Pharmacology, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 030104 developmental biology, 0302 clinical medicine, Developmental Neuroscience, Platelet inhibitor, Phase (matter), Neurology (clinical), Geriatrics and Gerontology, 030217 neurology & neurosurgery

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ed8cfe36c49160dd8f250dc4747172c9Test
    https://doi.org/10.1016/j.jalz.2016.06.650Test


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  5. 5
    Novel evidence-based colchicine dose-reduction algorithm to predict and prevent colchicine toxicity in the presence of cytochrome P450 3A4/P-glycoprotein inhibitors

    المؤلفون: Matthew W. Davis, Daniel E. Furst, Karin A. Kook, Jennifer L. DiGiacinto, Robert Terkeltaub

    المصدر: Arthritis & Rheumatism. 63:2226-2237

    مصطلحات موضوعية: Adult, Male, ATP Binding Cassette Transporter, Subfamily B, Adolescent, Immunology, Pharmacology, chemistry.chemical_compound, Rheumatology, Pharmacokinetics, Clarithromycin, medicine, Cytochrome P-450 CYP3A, Humans, Immunology and Allergy, Colchicine, Drug Interactions, Pharmacology (medical), Diltiazem, Enzyme Inhibitors, Evidence-Based Medicine, business.industry, Area under the curve, Middle Aged, chemistry, Cytochrome P-450 CYP3A Inhibitors, Verapamil, Female, Ketoconazole, Ritonavir, business, Algorithm, Algorithms, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68121fa562affca635b38899c27765b3Test
    https://doi.org/10.1002/art.30389Test


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  6. 6
    Tau aggregation inhibitor therapy: an exploratory phase 2 study in mild or moderate Alzheimer's disease

    المؤلفون: Alison D. Murray, Damon Wischik, Peter Bentham, Karin A Kook, Claude M. Wischik, Roger T. Staff, Charles R. Harrington, John Storey

    المصدر: Journal of Alzheimer's disease : JAD. 44(2)

    مصطلحات موضوعية: Male, medicine.medical_specialty, Pathology, Tau protein, tau Proteins, Exploratory phase, Disease, Gastroenterology, Double-Blind Method, Platelet inhibitor, Alzheimer Disease, Internal medicine, medicine, Dementia, Humans, Aged, Psychiatric Status Rating Scales, Tomography, Emission-Computed, Single-Photon, biology, Dose-Response Relationship, Drug, business.industry, General Neuroscience, Brain, General Medicine, medicine.disease, Effective dose (pharmacology), Methylene Blue, Psychiatry and Mental health, Clinical Psychology, Dose–response relationship, Neuroprotective Agents, Treatment Outcome, Cerebral blood flow, Cerebrovascular Circulation, biology.protein, Erythrocyte Count, Female, Geriatrics and Gerontology, business

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ac3ee94013b944246f3d433ec1c601Test
    https://pubmed.ncbi.nlm.nih.gov/25550228Test


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  7. 7
    A RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, CONTROLLED DOSE COMPARISON OF THALIDOMIDE FOR TREATMENT OF ERYTHEMA NODOSUM LEPROSUM

    المؤلفون: Tranquilino T. Fajardo, Esterlina V. Tan, Maria V. Balagon, R. V. Cellona, Janet Wittes, Laarni G. Villahermosa, Jeffrey P. Palmer, Rodolfo M. Abalos, Gerald P. Walsh, Douglas S. Walsh, Steven D. Thomas, Karin A. Kook

    المصدر: The American Journal of Tropical Medicine and Hygiene. 72:518-526

    مصطلحات موضوعية: medicine.medical_specialty, Chemotherapy, Every Two Weeks, business.industry, medicine.medical_treatment, Group A, Gastroenterology, Group B, law.invention, Surgery, Discontinuation, Thalidomide, Infectious Diseases, Randomized controlled trial, law, Virology, Internal medicine, Medicine, Parasitology, business, medicine.drug, Antibacterial agent

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::10390464525c888ca1c1503ff6016b1cTest
    https://doi.org/10.4269/ajtmh.2005.72.518Test


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  8. 8
    Clinical Pharmacokinetics of Thalidomide

    المؤلفون: Karin A. Kook, Markian S. Jaworsky, Steve K. Teo, William Tracewell, Michael A. Scheffler, David I. Stirling, Wayne A. Colburn, Steve D. Thomas, Oscar L. Laskin

    المصدر: Clinical Pharmacokinetics. 43:311-327

    مصطلحات موضوعية: food.ingredient, Anti-Inflammatory Agents, Cmax, Antineoplastic Agents, Pharmacology, Grapefruit juice, food, Pharmacokinetics, Oral administration, Animals, Humans, Medicine, Pharmacology (medical), Antibacterial agent, Volume of distribution, business.industry, Liver Diseases, Half-life, Stereoisomerism, Thalidomide, Area Under Curve, Kidney Diseases, business, Half-Life, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4393f2aa140453d0754ee9d1d9c32b99Test
    https://doi.org/10.2165/00003088-200443050-00004Test


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  9. 9
    Thalidomide Dose Proportionality Assessment following Single Doses to Healthy Subjects

    المؤلفون: Wayne A. Colburn, Karin A. Kook, Steve K. Teo, Steve D. Thomas, David I. Stirling, Michael R. Scheffler, William Tracewell

    المصدر: The Journal of Clinical Pharmacology. 41:662-667

    مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Nausea, Cmax, Leprostatic Agents, Gastroenterology, Pharmacokinetics, Oral administration, Internal medicine, medicine, Humans, Pharmacology (medical), Adverse effect, Pharmacology, business.industry, Body Weight, Middle Aged, Crossover study, Thalidomide, Area Under Curve, Anesthesia, Female, medicine.symptom, Complication, business, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d44701c13b31341240f8d46ffaccfaTest
    https://doi.org/10.1177/00912700122010555Test


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  10. 10
    Effect of a high-fat meal on thalidomide pharmacokinetics and the relative bioavailability of oral formulations in healthy men and women

    المؤلفون: Karin A. Kook, William G. Tracewell, David I. Stirling, Steve D. Thomas, Steve K. Teo, Michael R. Scheffler, Wayne A. Colburn

    المصدر: Biopharmaceutics & Drug Disposition. 21:33-40

    مصطلحات موضوعية: Pharmacology, Meal, business.industry, Pharmaceutical Science, General Medicine, Crossover study, Dosage form, Bioavailability, Thalidomide, Single oral dose, Animal science, Pharmacokinetics, Oral administration, medicine, Pharmacology (medical), business, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7ffcb6becfab82a47683a2902f28d3eaTest
    https://doi.org/10.1002/1099-081xTest(200001)21:1<33::aid-bdd213>3.0.co;2-r


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