المؤلفون: Ralph Adams, Callum Joyce, Mikhail Kuravskiy, Katriona Harrison, Zainab Ahdash, Matthew Balmforth, Kelda Chia, Cinzia Marceddu, Matthew Coates, James Snowden, Emmanuel Goursaud, Karelle Ménochet, Jean van den Elsen, Richard J. Payne, Alastair D. G. Lawson, Anthony Scott-Tucker, Alex Macpherson

المصدر: Frontiers in Immunology, Vol 14 (2023)

مصطلحات موضوعية: knob domain, bispecific, albumin, ultralong CDRH3, peptide, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170357/fullTest; https://doaj.org/toc/1664-3224Test

الوصول الحر: https://doaj.org/article/5c26260ce26243edb8dff99434087fe9Test

المؤلفون: Karelle Ménochet, Hongbin Yu, Bonnie Wang, Jay Tibbitts, Cheng-Pang Hsu, Amrita V. Kamath, Wolfgang F. Richter, Andreas Baumann

المصدر: mAbs, Vol 14, Iss 1 (2022)

مصطلحات موضوعية: 3Rs, antibodies, dose prediction, immunogenicity, Non-human primate, nonspecific clearance, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1942-0862Test; https://doaj.org/toc/1942-0870Test

الوصول الحر: https://doaj.org/article/0dd48640109d457fb44fab13cc929494Test

المؤلفون: Hiroyuki Takita, Shelby Barnett, Yueping Zhang, Karelle Ménochet, Hong Shen, Kayode Ogungbenro, Aleksandra Galetin

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 137-147 (2021)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2163-8306Test

الوصول الحر: https://doaj.org/article/bcb3eb0e26ae41549ab32adc6ba6bc94Test

المؤلفون: Aleksandra Galetin, Barnett Shelby, Galetin Aleksandra, Hiroyuki Takita, Hong Shen, Karelle Menochet, Kayode Ogungbenro, Menochet Karelle, Ogungbenro Kayode, Shelby Barnett, Shen Hong, Yueping Zhang, Zhang Yueping, 滝田 浩之

المصدر: Annual Scientific Meeting of The Japanese Society of Clinical Pharmacology and Therapeutics. 2021, :2-6

المؤلفون: Emma Davé, Oliver Durrant, Neha Dhami, Joanne Compson, Janice Broadbridge, Sophie Archer, Asher Maroof, Kevin Whale, Karelle Menochet, Pierre Bonnaillie, Emily Barry, Gavin Wild, Claude Peerboom, Pallavi Bhatta, Mark Ellis, Matthew Hinchliffe, David P. Humphreys, Sam P. Heywood

المصدر: mAbs, Vol 15, Iss 1 (2023)

مصطلحات موضوعية: TrYbe®, multi-specific, monovalent, Fc-free, targeting, multivalent antigen, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

العلاقة: https://doaj.org/toc/1942-0862Test; https://doaj.org/toc/1942-0870Test; https://doaj.org/article/da5a5f25917d459295f40b2ca83010e7Test

الإتاحة: https://doi.org/10.1080/19420862.2022.2160229Test
https://doaj.org/article/da5a5f25917d459295f40b2ca83010e7Test

المؤلفون: Melanie Golding (14282832), Oliver Light (14282835), Beth Williamson (8306304), Karelle Ménochet (7323398)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Biotechnology, Sociology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Transporters, uptake, clearance, hepatocytes, pharmacokinetics

العلاقة: https://figshare.com/articles/journal_contribution/Use_of_selective_substrates_and_inhibitors_to_rapidly_characterise_batches_of_cryopreserved_primary_human_hepatocytes_for_assessment_of_active_uptake_liability_in_drug_discovery_and_development/21756027Test

الإتاحة: https://doi.org/10.6084/m9.figshare.21756027.v1Test

المؤلفون: Karelle Ménochet, Hugues Chanteux, Jamie Henshall, Jean‐Marie Nicolas, Sara Wright, Judith Asperen, Anna‐Lena Ungell

المصدر: Oral Drug Delivery for Modified Release Formulations. :39-64

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ff24b31ea799d56398aef0f1683f70d5Test
https://doi.org/10.1002/9781119772729.ch3Test

المؤلفون: Ralph Adams, Callum Joyce, Mikhail Kuravskiy, Katriona Harrison, Zainab Ahdash, Matthew Balmforth, Kelda Chia, Cinzia Marceddu, Matthew Coates, James Snowden, Emmanuel Goursaud, Karelle Ménochet, Jean van den Elsen, Richard J. Payne, Alastair D. G. Lawson, Anthony Scott-Tucker, Alex Macpherson

مصطلحات موضوعية: Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, knob domain, bispecific, albumin, ultralong CDRH3, peptide

العلاقة: https://figshare.com/articles/dataset/DataSheet_1_Serum_albumin_binding_knob_domains_engineered_within_a_VH_framework_III_bispecific_antibody_format_and_as_chimeric_peptides_docx/22809077Test

الإتاحة: https://doi.org/10.3389/fimmu.2023.1170357.s001Test
https://figshare.com/articles/dataset/DataSheet_1_Serum_albumin_binding_knob_domains_engineered_within_a_VH_framework_III_bispecific_antibody_format_and_as_chimeric_peptides_docx/22809077Test

المؤلفون: Hugues Chanteux, Adrian Hall, Marie Ledecq, Karelle Ménochet, Monika-Sarah E D Schulze

المصدر: Journal of Medicinal Chemistry. 64:6413-6522

مصطلحات موضوعية: Computational biology, Molecular Dynamics Simulation, Ligands, digestive system, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, Xenobiotic receptor, Drug Discovery, Cytochrome P-450 CYP3A, Humans, 030304 developmental biology, 0303 health sciences, Pregnane X receptor, Molecular interactions, Binding Sites, Chemistry, Drug discovery, Pregnane X Receptor, Empirical design, digestive system diseases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Drug Design, Molecular Medicine, Structure based, Rifampin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f3b9a61bdc4cd3ef95075da3a5aa51Test
https://doi.org/10.1021/acs.jmedchem.0c02245Test

المؤلفون: Hong Shen, Karelle Ménochet, Yueping Zhang, Hiroyuki Takita, Kayode Ogungbenro, Shelby Barnett, Aleksandra Galetin

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 137-147 (2021)
Takita, H, Barnett, S, Zhang, Y, Ménochet, K, Shen, H, Ogungbenro, K & Galetin, A 2021, ' PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter-Individual Variability ', CPT: Pharmacometrics and Systems Pharmacology . https://doi.org/10.1002/psp4.12582Test
CPT: Pharmacometrics & Systems Pharmacology

مصطلحات موضوعية: Male, Coproporphyrins, Physiologically based pharmacokinetic modelling, Genotype, Physiology, Urine, Kidney, Models, Biological, Sensitivity and Specificity, Article, Drug Development, Pharmacokinetics, Liver tissue, Ethnicity, Humans, Medicine, Drug Interactions, Pharmacology (medical), Coproporphyrin I, Observer Variation, Sex Characteristics, biology, Liver-Specific Organic Anion Transporter 1, business.industry, Research, lcsh:RM1-950, Biological Transport, Articles, Healthy Volunteers, lcsh:Therapeutics. Pharmacology, Liver, Modeling and Simulation, biology.protein, Biomarker (medicine), Female, SLCO1B1, business, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294c4b448515b976395f4a3a766cae29Test
https://doaj.org/article/bcb3eb0e26ae41549ab32adc6ba6bc94Test