المؤلفون: Olkinuora, Alisa, Nieminen, Taina T., Douglas, Suvi, Kauppinen, Anni, Kontro, Mika, Väänänen, Juho, Kankainen, Matti, Ristimäki, Ari, Mäkinen, Markus, Lahermo, Paivi, Heckman, Caroline, Saarela, Janna, Salonen, Milla, Lepistö, Anna, Järvinen, Heikki, Mecklin, Jukka-Pekka, Kilpivaara, Outi, Wartiovaara-Kautto, Ulla, Porkka, Kimmo, Peltomäki, Päivi

المساهمون: Department of Medical and Clinical Genetics, ATG - Applied Tumor Genomics, Research Programs Unit, Clinicum, Institute for Molecular Medicine Finland, HUS Comprehensive Cancer Center, Department of Oncology, Helsinki Institute of Life Science HiLIFE, HUSLAB, TRIMM - Translational Immunology Research Program, HUS Diagnostic Center, Digital Precision Cancer Medicine (iCAN), Department of Pathology, Janna Saarela / Principal Investigator, Medicum, Helsinki One Health (HOH), Hannes Tapani Lohi / Principal Investigator, Veterinary Biosciences, HUS Abdominal Center, II kirurgian klinikka, Department of Surgery, University of Helsinki, Hematologian yksikkö

مصطلحات موضوعية: Transcription, Repair, 3122 Cancers

وصف الملف: application/pdf

العلاقة: Olkinuora , A , Nieminen , T T , Douglas , S , Kauppinen , A , Kontro , M , Väänänen , J , Kankainen , M , Ristimäki , A , Mäkinen , M , Lahermo , P , Heckman , C , Saarela , J , Salonen , M , Lepistö , A , Järvinen , H , Mecklin , J-P , Kilpivaara , O , Wartiovaara-Kautto , U , Porkka , K & Peltomäki , P 2023 , ' Identification of DHX40 as a candidate susceptibility gene for colorectal and hematological neoplasia ' , Leukemia , vol. 37 , no. 11 , pp. 2301–2305 . https://doi.org/10.1038/s41375-023-02021-9Test , https://doi.org/10.1038/s41375-023-02021-9Test; ORCID: /0000-0002-0853-6219/work/147912422; ORCID: /0000-0002-5866-4059/work/147915924; ORCID: /0000-0003-4412-688X/work/147917903; ORCID: /0000-0001-8819-2980/work/147918351; ORCID: /0000-0001-6353-0664/work/147918380; ORCID: /0000-0003-4112-5902/work/147918421; ORCID: /0000-0003-3987-9924/work/147918495; ORCID: /0000-0002-9901-7923/work/147918500; ORCID: /0000-0002-0662-7483/work/147918691; ORCID: /0000-0001-8467-2100/work/156157851; http://hdl.handle.net/10138/567868Test; 25a3a4a4-fa9a-4a57-b3aa-b3324a1c517b; 001094562000001

الإتاحة: http://hdl.handle.net/10138/567868Test

المؤلفون: Kankuri, Esko, Finckenberg, Piet, Leinonen, Jussi, Tarkia, Miikka, Björk, Susann, Purhonen, J., Kallijärvi, Jukka, Kankainen, Matti, Soliymani, Rabah, Łałowski, Maciej, Mervaala, Eero

المساهمون: Esko Markus Kankuri / Principal Investigator, Medicum, Department of Pharmacology, STEMM - Stem Cells and Metabolism Research Program, HUSLAB, TRIMM - Translational Immunology Research Program, Department of Biochemistry and Developmental Biology, Helsinki Institute of Life Science HiLIFE, Doctoral Programme in Biomedicine, Doctoral Programme in Population Health, Doctoral Programme in Drug Research, Eero Mervaala / Principal Investigator

مصطلحات موضوعية: Medical biotechnology, Heart, regeneration, myocardial infarction, acylcarnitines, carnitine-acylcarnitine translocase

وصف الملف: application/pdf

العلاقة: Kankuri , E , Finckenberg , P , Leinonen , J , Tarkia , M , Björk , S , Purhonen , J , Kallijärvi , J , Kankainen , M , Soliymani , R , Łałowski , M & Mervaala , E 2023 , ' Altered acylcarnitine metabolism and inflexible mitochondrial fuel utilization characterize the loss of neonatal myocardial regeneration capacity ' , Experimental & Molecular Medicine , vol. 55 , no. 4 , pp. 806–817 . https://doi.org/10.1038/s12276-023-00967-5Test; ORCID: /0000-0002-3683-4096/work/138278252; ORCID: /0000-0003-3773-7025/work/138280905; http://hdl.handle.net/10138/563109Test; 6c3db1d0-042f-446d-a8f7-978259e6e45f; 001066758000012

الإتاحة: http://hdl.handle.net/10138/563109Test

المؤلفون: Viitasalo, Liisa, Kettunen, Kaisa, Kankainen, Matti, Niemelä, Elina H., Kiiski, Kirsi

المساهمون: HUSLAB, HUS Diagnostic Center, Department of Clinical Pharmacology, Department of Medical and Clinical Genetics, TRIMM - Translational Immunology Research Program, Helsinki Institute of Life Science HiLIFE

مصطلحات موضوعية: de novo, duplication, JARID2, pathogenic variant, RNA sequencing, whole genome sequencing, DEVELOPMENTAL REGULATORS, PRC2, JUMONJI, POLYCOMB, 3111 Biomedicine, 1184 Genetics, developmental biology, physiology

وصف الملف: application/pdf

العلاقة: We would like to thank the family for taking part in this research. The authors thank Hanna Tammio for excellent technical assistance and MD PhD Kristiina Avela and MD PhD Sonja Strang‐Karlsson for great support in clinical evaluations. We also thank the Core facility Sequencing Unit at FIMM Technology Centre supported by University of Helsinki and Biocenter Finland.; Viitasalo , L , Kettunen , K , Kankainen , M , Niemelä , E H & Kiiski , K 2022 , ' A novel partial de novo duplication of JARID2 gene causing a neurodevelopmental phenotype ' , Molecular Genetics and Genomic Medicine , vol. 10 , no. 11 , 2037 . https://doi.org/10.1002/mgg3.2037Test; ORCID: /0000-0001-7402-461X/work/127504100; 85135940160; 95f3204d-4dc1-43ac-8ddb-8d508eb7ab9c; http://hdl.handle.net/10138/353530Test; 000842377300001

الإتاحة: http://hdl.handle.net/10138/353530Test

المؤلفون: Nuutila, Kristo, Katayama, Shintaro, Laitinen, Anita, Siltanen, Antti, Patrikoski, Mimmi, Valtonen, Jussi, Kankainen, Matti, Kerkelä, Erja, Kaartinen, Tanja, Juteau, Susanna, Korhonen, Matti, Vuola, Jyrki, Kankuri, Esko

المساهمون: Research Programs Unit, STEMM - Stem Cells and Metabolism Research Program, Department of Pharmacology, HUS Musculoskeletal and Plastic Surgery, Plastiikkakirurgian yksikkö, Clinicum, HUSLAB, TRIMM - Translational Immunology Research Program, Department of Medical and Clinical Genetics, Department of Pathology, Esko Markus Kankuri / Principal Investigator, Medicum

مصطلحات موضوعية: Burns, Cell therapy, Epithelialization, Keratinocytes, Skin wound healing, Transcriptome, 3126 Surgery, anesthesiology, intensive care, radiology

وصف الملف: application/pdf

العلاقة: Nuutila , K , Katayama , S , Laitinen , A , Siltanen , A , Patrikoski , M , Valtonen , J , Kankainen , M , Kerkelä , E , Kaartinen , T , Juteau , S , Korhonen , M , Vuola , J & Kankuri , E 2023 , ' ATMP-classified, scalable, autologous cell spray for the treatment of skin wounds and assessment of its effects on wound healing clinically and on a molecular level ' , Burns , vol. 49 , no. 5 , pp. 1144-1156 . https://doi.org/10.1016/j.burns.2022.09.006Test; f2f5fe64-4115-4f1a-b61f-65be76e636a0; http://hdl.handle.net/10138/565080Test; 001053401500001

الإتاحة: http://hdl.handle.net/10138/565080Test

المؤلفون: Nurminen, Anssi, Jaatinen, Serafiina, Taavitsainen, Sinja, Hognas, Gunilla, Lesluyes, Tom, Ansari-Pour, Naser, Tolonen, Teemu, Haase, Kerstin, Koskenalho, Antti, Kankainen, Matti, Jasu, Juho, Rauhala, Hanna, Kesaniemi, Jenni, Nikupaavola, Tiia, Kujala, Paula, Rinta-Kiikka, Irina, Riikonen, Jarno, Kaipia, Antti, Murtola, Teemu, Tammela, Teuvo L., Visakorpi, Tapio, Nykter, Matti, Wedge, David C., Van Loo, Peter, Bova, G. Steven

المساهمون: HUSLAB, Institute for Molecular Medicine Finland

مصطلحات موضوعية: Cancer anatomic origins, Cancer evolution, Cancer genomic drivers, Cancer heterogeneity, Cancer phylogenetics, Cancer timing, Prostate cancer, Prostate cancer metastasis, Spatiogenomic evolutionary tracing, 1184 Genetics, developmental biology, physiology

وصف الملف: application/pdf

العلاقة: Nurminen , A , Jaatinen , S , Taavitsainen , S , Hognas , G , Lesluyes , T , Ansari-Pour , N , Tolonen , T , Haase , K , Koskenalho , A , Kankainen , M , Jasu , J , Rauhala , H , Kesaniemi , J , Nikupaavola , T , Kujala , P , Rinta-Kiikka , I , Riikonen , J , Kaipia , A , Murtola , T , Tammela , T L , Visakorpi , T , Nykter , M , Wedge , D C , Van Loo , P & Bova , G S 2023 , ' Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis : prospects for personalized medicine ' , Genome medicine , vol. 15 , no. 1 , 82 . https://doi.org/10.1186/s13073-023-01242-yTest; f2e7fa8f-9af6-4a11-9ae5-de6a038191a9; http://hdl.handle.net/10138/567078Test; 001082973100001

الإتاحة: http://hdl.handle.net/10138/567078Test

المؤلفون: Talwelkar, Sarang S., Mayranpaa, Mikko I., Schuler, Julia, Linnavirta, Nora, Hemmes, Annabrita, Adinolfi, Simone, Kankainen, Matti, Sommergruber, Wolfgang, Levonen, Anna-Liisa, Rasanen, Jari, Knuuttila, Aija, Verschuren, Emmy W., Wennerberg, Krister

المصدر: Talwelkar , S S , Mayranpaa , M I , Schuler , J , Linnavirta , N , Hemmes , A , Adinolfi , S , Kankainen , M , Sommergruber , W , Levonen , A-L , Rasanen , J , Knuuttila , A , Verschuren , E W & Wennerberg , K 2023 , ' PI3Kβ inhibition enhances ALK-inhibitor sensitivity in ALK -rearranged lung cancer ' , Molecular Oncology , vol. 17 , no. 5 , pp. 747-764 . https://doi.org/10.1002/1878-0261.13342Test

مصطلحات موضوعية: ALK-rearranged lung cancer, combination treatment, drug resistance, EGFR, EML4-ALK, NSCLC, patient-derived cells, PI3K beta, CRIZOTINIB, RESISTANCE, P110-BETA, COMBINATION, MUTATION, AZD8186, BREAST, GROWTH, GENE

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1002/1878-0261.13342Test
https://curis.ku.dk/portal/da/publications/pi3k-inhibition-enhances-alkinhibitor-sensitivity-in-alkrearranged-lung-cancerTest(b2670bc5-99d6-4a05-a26f-eb8561d2e5c7).html
https://curis.ku.dk/ws/files/346255138/Molecular_Oncology_2022_Talwelkar_PI3K_inhibition_enhances_ALK_inhibitor_sensitivity_in_ALK_rearranged_lung_cancer.pdfTest

المؤلفون: Dufva, Olli, Gandolfi, Sara, Huuhtanen, Jani, Dashevsky, Olga, Duàn, Hanna, Saeed, Khalid, Klievink, Jay, Nygren, Petra, Bouhlal, Jonas, Lahtela, Jenni, Näätänen, Anna, Ghimire, Bishwa R., Hannunen, Tiina, Ellonen, Pekka, Lähteenmäki, Hanna, Rumm, Pauliina, Theodoropoulos, Jason, Laajala, Essi, Härkönen, Jouni, Pölönen, Petri, Heinäniemi, Merja, Hollmén, Maija, Yamano, Shizuka, Shirasaki, Ryosuke, Barbie, David A., Roth, Jennifer A., Romee, Rizwan, Sheffer, Michal, Lähdesmäki, Harri, Lee, Dean A., De Matos Simoes, Ricardo, Kankainen, Matti, Mitsiades, Constantine S., Mustjoki, Satu

المساهمون: Department of Computer Science, Computer Science Professors, Computer Science - Computational Life Sciences (CSLife), Computer Science - Artificial Intelligence and Machine Learning (AIML), Helsinki Institute for Information Technology (HIIT), Professorship Lähdesmäki Harri, University of Helsinki, Harvard Medical School, University of Eastern Finland, St Jude Children's Research Hospital, University of Turku, Broad Institute, Nationwide Children's Hospital, Aalto-yliopisto, Aalto University

مصطلحات موضوعية: cancer, CRISPR screening, CROP-seq, functional genomics, immunotherapy resistance, leukemia, lymphoma, myeloma, NK cell, single-cell RNA sequencing

وصف الملف: 2816-2835; application/pdf

العلاقة: IMMUNITY; Volume 56, issue 12; Dufva, O, Gandolfi, S, Huuhtanen, J, Dashevsky, O, Duàn, H, Saeed, K, Klievink, J, Nygren, P, Bouhlal, J, Lahtela, J, Näätänen, A, Ghimire, B R, Hannunen, T, Ellonen, P, Lähteenmäki, H, Rumm, P, Theodoropoulos, J, Laajala, E, Härkönen, J, Pölönen, P, Heinäniemi, M, Hollmén, M, Yamano, S, Shirasaki, R, Barbie, D A, Roth, J A, Romee, R, Sheffer, M, Lähdesmäki, H, Lee, D A, De Matos Simoes, R, Kankainen, M, Mitsiades, C S & Mustjoki, S 2023, ' Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers ', IMMUNITY, vol. 56, no. 12, e13, pp. 2816-2835 . https://doi.org/10.1016/j.immuni.2023.11.008Test; PURE UUID: e6b48079-6c19-4daf-bf6f-08a886700fa7; PURE ITEMURL: https://research.aalto.fi/en/publications/e6b48079-6c19-4daf-bf6f-08a886700fa7Test; PURE LINK: http://www.scopus.com/inward/record.url?scp=85179470331&partnerID=8YFLogxKTest; PURE FILEURL: https://research.aalto.fi/files/131701300/Single-cell_functional_genomics_reveals_determinants_of_sensitivity_and_resistance_to_natural_killer_cells_in_blood_cancers.pdfTest; https://aaltodoc.aalto.fi/handle/123456789/125566Test; URN:NBN:fi:aalto-202401041255

الإتاحة: https://doi.org/10.1016/j.immuni.2023.11.008Test
https://aaltodoc.aalto.fi/handle/123456789/125566Test

المؤلفون: Timonen, Sanna, Rebecca Gasparini, Vanessa, Piekkari, Ella, Dufva, Olli, Awad, Shady, Akimov, Yevhen, von Jan, Jana, Braun, Till, Ianevski, Aleksandr, Kankainen, Matti, Klievink, Jay, Herling, Marco, Aittokallio, Tero, Mustjoki, Satu

المصدر: HemaSphere ; volume 7, issue S3, page e0412416 ; ISSN 2572-9241

الإتاحة: https://doi.org/10.1097/01.hs9.0000971804.04124.16Test

المؤلفون: Ojala, Teija, Häkkinen, Aino-Elina, Kankuri, Esko, Kankainen, Matti

المساهمون: Suomen Kulttuurirahasto, Business Finland, Academy of Finland

المصدر: Trends in Genetics ; volume 39, issue 9, page 686-702 ; ISSN 0168-9525

مصطلحات موضوعية: Genetics

الإتاحة: https://doi.org/10.1016/j.tig.2023.05.004Test
https://api.elsevier.com/content/article/PII:S0168952523001270?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0168952523001270?httpAccept=text/plainTest

المؤلفون: Ojala, Teija, Kankuri, Esko, Kankainen, Matti

المساهمون: Suomen Kulttuurirahasto, Business Finland, Academy of Finland

المصدر: Trends in Molecular Medicine ; volume 29, issue 5, page 376-389 ; ISSN 1471-4914

مصطلحات موضوعية: Molecular Biology, Molecular Medicine

الإتاحة: https://doi.org/10.1016/j.molmed.2023.02.002Test
https://api.elsevier.com/content/article/PII:S1471491423000345?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1471491423000345?httpAccept=text/plainTest