SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma
| العنوان: | SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma |
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| المؤلفون: | Hsiao, Yi-Jing, Su, Kang-Yi, Hsu, Yi-Chiung, Chang, Gee-Chen, Chen, Jin-Shing, Chen, Hsuan-Yu, Hong, Qi-Sheng, Hsu, Shih-Chun, Kang, Po-Hsiang, Hsu, Chia-Ying, Ho, Bing-Ching, Yang, Tsung-Hui, Wang, Chia-Yu, Jou, Yuh-Shan, Yang, Pan-Chyr, Yu, Sung-Liang, 何炳慶, 俞松良, 蘇剛毅, 楊泮池, 陳晉興 |
| المساهمون: | 臺大醫院-內科部, 臺大醫院-外科部, 臺大醫院-檢驗醫學部, 臺大醫學院, 臺大醫學院-光電生物醫學研究中心, 臺大醫學院-病理學科暨研究所, 臺大醫學院-醫學檢驗暨生物技術學系暨研究所, 臺大醫學院-醫療器材與醫學影像研究所, Hsiao, Yi-Jing, Su, Kang-Yi, Hsu, Yi-Chiung, Chang, Gee-Chen, Chen, Jin-Shing, Chen, Hsuan-Yu, Hong, Qi-Sheng, Hsu, Shih-Chun, Kang, Po-Hsiang, Hsu, Chia-Ying, Ho, Bing-Ching, Yang, Tsung-Hui, Wang, Chia-Yu, Jou, Yuh-Shan, Yang, Pan-Chyr, Yu, Sung-Liang, 何炳慶, 俞松良, 蘇剛毅, 楊泮池, 陳晉興 |
| سنة النشر: | 2016 |
| المجموعة: | National Taiwan University Institutional Repository (NTUR) |
| مصطلحات موضوعية: | SPANX family, AP-1, SLUG, E-cadherin, metastasis |
| الوقت: | 136 |
| الوصف: | SPANXA (Sperm Protein Associated with the Nucleus on the X-chromosome, family members A1/A2) acts as a cancer-testis antigen expressed in normal testes, but dysregulated in various tumors. We found that SPANXA is highly expressed in low-invasive CL1-0 cells compared with isogenous high-invasive CL1-5 cells. SPANXA was preferably expressed in tumor tissues and associated with the prolonged survival of lung adenocarcinomas. SPANXA suppressed the invasion and metastasis of lung cancer cells in vitro and in vivo. By the expression microarray and pathway analysis, we found that the SPANXA-altered genes were enriched in the epithelial-mesenchymal transition (EMT) pathway. SPANXA reduced SNAI2 expression resulted in up-regulating E-cadherin. c-JUN acts as the positive-regulator of EMT. Silencing SPANXA increased c-JUN mRNA expression and blockage of c-JUN led to SNAI2 down-regulation. Our results clearly characterized SPANXA as an EMT inhibitor by suppressing c-JUN-SNAI2 axis in lung adenocarcinoma. ; 病理學科暨研究所 ; 醫學院 ; 期刊論文 |
| نوع الوثيقة: | other/unknown material |
| اللغة: | English |
| العلاقة: | Oncotarget, 7(28), 44417-44429; http://ntur.lib.ntu.edu.tw/handle/246246/278778Test |
| DOI: | 10.18632/oncotarget.10088 |
| الإتاحة: | https://doi.org/10.18632/oncotarget.10088Test http://ntur.lib.ntu.edu.tw/handle/246246/278778Test |
| رقم الانضمام: | edsbas.A1BD898E |
| قاعدة البيانات: | BASE |
| DOI: | 10.18632/oncotarget.10088 |
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