دورية أكاديمية
Monitoring of serum magnesium levels during long-term use of proton pump inhibitors in elderly japanese patients: is it really necessary or not?
| العنوان: | Monitoring of serum magnesium levels during long-term use of proton pump inhibitors in elderly japanese patients: is it really necessary or not? |
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| المؤلفون: | Nobuhiko Nakamura, Kanaha Yoneda, Takashi Higo, Masaaki Kusumoto |
| المصدر: | Journal of Pharmaceutical Health Care and Sciences, Vol 8, Iss 1, Pp 1-7 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | Proton pump inhibitors, Long-term use, Serum magnesium, Hypomagnesemia, Elderly patients, Japan, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441 |
| الوصف: | Abstract Background Long-term use of proton pump inhibitors (PPIs) has been found to significantly lower serum magnesium levels in patients in the USA and Europe. The package inserts of PPIs in these countries clearly state that healthcare professionals should consider monitoring magnesium levels prior to initiation of PPI treatment and periodically thereafter. However, the package inserts of PPIs in Japan do not clearly mention the monitoring of magnesium levels. In this study, we evaluated the relationship between long-term use of PPIs and the lower serum magnesium concentrations in elderly Japanese patients. Methods Using a retrospective observational approach, a total of 264 Japanese outpatients were included in the study. Patients over the age of 75 years were considered elderly. Serum magnesium levels of the patients were measured in units of 0.1 mg/dL between January 2016 and June 2022 at the Higo Internal Medicine Clinic and Ai Pharmacy in Kyoto, Japan. Results Four of the 264 eligible patients were diagnosed with hypomagnesemia. Three were PPI non-users, and one was a PPI user. Serum magnesium concentrations were significantly lower in PPI users (n = 47) than in non-users (n = 85; 2.1 ± 0.2 vs. 2.2 ± 0.3 mg/dL, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2055-0294 |
| العلاقة: | https://doaj.org/toc/2055-0294Test |
| DOI: | 10.1186/s40780-022-00266-7 |
| الوصول الحر: | https://doaj.org/article/5a3e8f29bb944e43b2759dbffea7e615Test |
| رقم الانضمام: | edsdoj.5a3e8f29bb944e43b2759dbffea7e615 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20550294 |
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| DOI: | 10.1186/s40780-022-00266-7 |