دورية أكاديمية

Heme oxygenase-1 repeat polymorphism in septic acute kidney injury

التفاصيل البيبلوغرافية
العنوان: Heme oxygenase-1 repeat polymorphism in septic acute kidney injury
المؤلفون: Vilander, L. M. (Laura M.), Vaara, S. T. (Suvi T.), Donner, K. M. (Kati M.), Lakkisto, P. (Paivi), Kaunisto, M. A. (Mari A.), Pettila, V. (Ville), Laru-Sompa, R. (Raili), Pulkkinen, A. (Anni), Saarelainen, M. (Minna), Reilama, M. (Mikko), Tolmunen, S. (Sinikka), Rantalainen, U. (Ulla), Miettinen, M. (Marja), Suvela, M. (Markku), Pesola, K. (Katrine), Saastamoinen, P. (Pekka), Kauppinen, S. (Sirpa), Kaukonen, K.-M. (Kirsi-Maija), Korhonen, A.-M. (Anna-Maija), Nisula, S. (Sara), Vaara, S. (Suvi), Suojaranta-Ylinen, R. (Raili), Mildh, L. (Leena), Haapio, M. (Mikko), Nurminen, L. (Laura), Sutinen, S. (Sari), Pettila, L. (Leena), Laitinen, H. (Helina), Syrja, H. (Heidi), Henttonen, K. (Kirsi), Lappi, E. (Elina), Boman, H. (Hillevi), Varpula, T. (Tero), Porkka, P. (Paivi), Sivula, M. (Mirka), Rahkonen, M. (Mira), Tsurkka, A. (Anne), Nieminen, T. (Taina), Prittinen, N. (Niina), Alaspaa, A. (Ari), Salanto, V. (Ville), Juntunen, H. (Hanna), Sanisalo, T. (Teija), Parviainen, I. (Ilkka), Uusaro, A. (Ari), Ruokonen, E. (Esko), Bendel, S. (Stepani), Rissanen, N. (Niina), Lang, M. (Maarit), Rahikainen, S. (Sari), Rissanen, S. (Saija), Ahonen, M. (Merja), Halonen, E. (Elina), Vaskelainen, E. (Eija), Poukkanen, M. (Meri), Lintula, E. (Esa), Suominen, S. (Sirpa), Heikkinen, J. (Jorma), Lavander, T. (Timo), Heinonen, K. (Kirsi), Juopperi, A.-M. (Anne-Mari), Kaminski, T. (Tadeusz), Gaddnas, F. (Fiia), Kuusela, T. (Tuija), Roiko, J. (Jane), Karlsson, S. (Sari), Reinikainen, M. (Matti), Surakka, T. (Tero), Jyrkonen, H. (Helena), Eiserbeck, T. (Tanja), Kallinen, J. (Jaana), Lund, V. (Vesa), Tuominen, P. (Paivi), Perkola, P. (Pauliina), Tuominen, R. (Riikka), Hietaranta, M. (Marika), Johansson, S. (Satu), Hovilehto, S. (Seppo), Kirsi, A. (Anne), Tiainen, P. (Pekka), Myllarinen, T. (Tuija), Leino, P. (Pirjo), Toropainen, A. (Anne), Kuitunen, A. (Anne), Leppanen, I. (Ilona), Levoranta, M. (Markus), Hoppu, S. (Sanna), Sauranen, J. (Jukka), Tenhunen, J. (Jyrki), Kukkurainen, A. (Atte), Kortelainen, S. (Samuli), Varila, S. (Simo), Inkinen, O. (Outi), Koivuviita, N. (Niina), Kotamaki, J. (Jutta), Laine, A. (Anu), Ala-Kokko, T. (Tero), Laurila, J. (Jouko), Salkio, S. (Sinikka), Koivisto, S.-P. (Simo-Pekka), Hautamaki, R. (Raku), Skinnar, M. (Maria)
بيانات النشر: Public Library of Science
سنة النشر: 2019
المجموعة: Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto
الوصف: Acute kidney injury (AKI) is a syndrome that frequently affects the critically ill. Recently, an increased number of dinucleotide repeats in the HMOX1 gene were reported to associate with development of AKI in cardiac surgery. We aimed to test the replicability of this finding in a Finnish cohort of critically ill septic patients. This multicenter study was part of the national FINNAKI study. We genotyped 300 patients with severe AKI (KDIGO 2 or 3) and 353 controls without AKI (KDIGO 0) for the guanine–thymine (GTn) repeat in the promoter region of the HMOX1 gene. The allele calling was based on the number of repeats, the cut off being 27 repeats in the S–L (short to long) classification, and 27 and 34 repeats for the S–M–L₂ (short to medium to very long) classification. The plasma concentrations of heme oxygenase-1 (HO-1) enzyme were measured on admission. The allele distribution in our patients was similar to that published previously, with peaks at 23 and 30 repeats. The S-allele increases AKI risk. An adjusted OR was 1.30 for each S-allele in an additive genetic model (95% CI 1.01–1.66; p = 0.041). Alleles with a repeat number greater than 34 were significantly associated with lower HO-1 concentration (p<0.001). In septic patients, we report an association between a short repeat in HMOX1 and AKI risk.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
الإتاحة: http://urn.fi/urn:nbn:fi-fe2020042822774Test
حقوق: info:eu-repo/semantics/openAccess ; © 2019 Vilander et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ; https://creativecommons.org/licenses/by/4.0Test/
رقم الانضمام: edsbas.FE2A2C76
قاعدة البيانات: BASE