التفاصيل البيبلوغرافية
| العنوان: |
Meta‐analysis of age‐related cognitive decline reveals a novel locus for the attention domain and implicates a COVID‐19‐related gene for global cognitive function |
| المؤلفون: |
Acharya, Vibha, Fan, Kang‐Hsien, Snitz, Beth E., Ganguli, Mary, DeKosky, Steven T., Lopez, Oscar L., Feingold, Eleanor, Kamboh, Mohammed Ilyas |
| المساهمون: |
National Institutes of Health |
| المصدر: |
Alzheimer's & Dementia ; volume 19, issue 11, page 5010-5022 ; ISSN 1552-5260 1552-5279 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2023 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
INTRODUCTION Cognitive abilities have substantial heritability throughout life, as shown by twin‐ and population‐based studies. However, there is limited understanding of the genetic factors related to cognitive decline in aging across neurocognitive domains. METHODS We conducted a meta‐analysis on 3045 individuals aged ≥65, derived from three population‐based cohorts, to identify genetic variants associated with the decline of five neurocognitive domains (attention, memory, executive function, language, visuospatial function) and global cognitive decline. We also conducted gene‐based and functional bioinformatics analyses. RESULTS Apolipoprotein E (APOE)4 was significantly associated with decline of memory ( p = 5.58E‐09) and global cognitive function ( p = 1.84E‐08). We identified a novel association with attention decline on chromosome 9, rs6559700 ( p = 2.69E‐08), near RASEF . Gene‐based analysis also identified a novel gene, TMPRSS11D , involved in the activation of SARS‐CoV‐2, to be associated with the decline in global cognitive function ( p = 4.28E‐07). DISCUSSION Domain‐specific genetic studies can aid in the identification of novel genes and pathways associated with decline across neurocognitive domains. Highlights rs6559700 was associated with decline of attention. APOE4 was associated with decline of memory and global cognitive decline. TMPRSS11D , a gene involved in the activation of SARS‐CoV‐2, was implicated in global cognitive decline. Cognitive domain abilities had both unique and shared molecular pathways across the domains. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/alz.13064 |
| الإتاحة: |
https://doi.org/10.1002/alz.13064Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.28B9209C |
| قاعدة البيانات: |
BASE |
