دورية أكاديمية
Seizure semiology in antibody-associated autoimmune encephalitis
| العنوان: | Seizure semiology in antibody-associated autoimmune encephalitis |
|---|---|
| المؤلفون: | Kaaden, Tillman, Rauer, Sebastian, Melzer, Nico, Malter, Michael P., Kunze, Albrecht |
| المصدر: | Neurology: Neuroimmunology & neuroinflammation. - 9, 6 (2022) , e200034, ISSN: 2332-7812 |
| سنة النشر: | 2022 |
| المجموعة: | University of Freiburg: FreiDok |
| الوصف: | Background and Objectives: To assess seizure characteristics in antibody (ab)-associated autoimmune encephalitis (ab + AE) with the 3 most prevalent abs against N-methyl-D-aspartate receptor (NMDAR), leucine-rich glioma-inactivated protein 1 (LGI1), and glutamic acid decarboxylase (GAD). Methods: Multicenter nationwide prospective cohort study of the German Network for Research in Autoimmune Encephalitis. Results: Three hundred twenty patients with ab + AE were eligible for analysis: 190 NMDAR+, 89 LGI1+, and 41 GAD+. Seizures were present in 113 (60%) NMDAR+, 69 (78%) LGI1+, and 26 (65%) GAD+ patients and as leading symptoms for diagnosis in 53 (28%) NMDAR+, 47 (53%) LGI+, and 20 (49%) GAD+ patients. Bilateral tonic-clonic seizures occurred with almost equal frequency in NMDAR+ (38/51, 75%) and GAD+ (14/20, 70%) patients, while being less common in LGI1+ patients (27/59, 46%). Focal seizures occurred less frequently in NMDAR+ (67/113; 59%) than in LGI1+ (54/69, 78%) or in GAD+ patients (23/26; 88%). An aura with déjà-vu phenomenon was nearly specific in GAD+ patients (16/20, 80%). Faciobrachial dystonic seizures (FBDS) were uniquely observed in LGI1+ patients (17/59, 29%). Status epilepticus was reported in one-third of NMDAR+ patients, but only rarely in the 2 other groups. The occurrence of seizures was associated with higher disease severity only in NMDAR+ patients. Discussion: Seizures are a frequent and diagnostically relevant symptom of ab + AE. Whereas NMDAR+ patients had few localizing semiological features, semiology in LGI1+ and GAD+ patients pointed toward a predominant temporal seizure onset. FBDS are pathognomonic for LGI1 + AE. Status epilepticus seems to be more frequent in NMDAR + AE. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| العلاقة: | https://freidok.uni-freiburg.de/data/230465Test |
| DOI: | 10.1212/nxi.0000000000200034 |
| الإتاحة: | https://doi.org/10.1212/nxi.0000000000200034Test https://freidok.uni-freiburg.de/data/230465Test https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2304656Test https://freidok.uni-freiburg.de/dnb/download/230465Test |
| حقوق: | free |
| رقم الانضمام: | edsbas.8946D7E2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1212/nxi.0000000000200034 |
|---|