المؤلفون: Anne R. Meyer, Monica E. Brown, Patrick S. McGrath, Peter J. Dempsey

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 843-856 (2022)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: ASCL2, Achaete-scute complex homolog 2, ISC, intestinal stem cells, Cell Plasticity, DCLK1, Doublecortin-like kinase 1, RC799-869, ATOH, atonal bHLH transcription factor 1, Intestinal Regeneration, BMI1, B cell-specific Moloney murine leukemia virus integration site 1, CLU, clusterin, TA, transit-amplifying, Homeostasis, Regeneration, DSS, dextran sodium sulfate, Stem Cell Niche, KRAS, kirsten rat sarcoma viral oncogene homolog, Original Research, EGF, epidermal growth factor, Hepatology, SCF, stem cell factor, DLL, delta like canonical Notch ligand, Gastroenterology, BMP, bone morphogenetic protein, ILC, innate lymphoid cell, LGR5+, leucine-rich repeat-containing G-protein–coupled receptor-5–positive, PDGFRα, platelet derived growth factor receptor alpha, Diseases of the digestive system. Gastroenterology, WNT, wingless-related integration site, FOXL1, forkhead box L1, IL, interleukin, Intestines, Cellular Plasticity, LRC, label-retaining cell, RTK, receptor tyrosine kinase, Intestinal Homeostasis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2c4548990c68ba5ebf409224d926beTest
http://www.sciencedirect.com/science/article/pii/S2352345X21002551Test

المؤلفون: Haibo Cheng, Zhigui Wu, Jian Gao, Manru Li, Hongqi Chen, Dongdong Sun, Rui Zhang, Yuxian Shen, Qiang Xu, Xianjia Qi, Yang Sun, Mingxia Zhao, Dijun Chen

المصدر: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 149-166 (2022)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Cell type, DSBs, double-strand breaks, Macrophage, Colorectal cancer, CNVs, copy number variations, medicine.medical_treatment, BTLA, B- and T-lymphocyte attenuator, MAPK, mitogen-activated kinase, RM1-950, STING, stimulator of interferon genes, Biology, PTPN11, SHP099, scRNA-seq, single-cell RNA-sequencing, GSEA, gene set enrichment analysis, t-SNE, t-distributed stochastic neighbor embedding, Interferon, scRNA-seq, KRAS, Kirsten rat sarcoma viral oncogene homolog, medicine, General Pharmacology, Toxicology and Pharmaceutics, Type I interferon, PCA, principal component analysis, Tumor microenvironment, CD68, TME, tumor microenvironment, Microsatellite instability, Immunosuppression, MSI, microsatellite instability, Immunotherapy, medicine.disease, MSS, microsatellite stable, digestive system diseases, APC, antigen-presenting cell, CRC, colorectal cancer, Cancer research, Original Article, Therapeutics. Pharmacology, PD-1, programmed cell death 1, medicine.drug, STING

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79268ea53d1ac127b470be7ad862d9e6Test
http://www.sciencedirect.com/science/article/pii/S2211383521002963Test

المؤلفون: Rebekka Van Hoof, Michal Szymonik, Stefanos K. Nomidis, Karen Hollanders, An Jacobs, Inge Nelissen, Patrick Wagner, Jef Hooyberghs

المساهمون: Nelissen, Inge, Szymonik, Michal, Nomidis, Stefanos K., HOOYBERGHS, Jef, Jacobs, An, Hollanders, Karen, VAN HOOF, Rebekka, WAGNER, Patrick

المصدر: Sensors and Actuators B: Chemical

مصطلحات موضوعية: Technology, EGFR, LoD, limit of detection, sensors, Microarray technology, T, target, PCR, polymerase chain reaction, S, signal, Materials Chemistry, KRAS, Kirsten rat sarcoma viral oncogene homolog, Electrochemistry, ctDNA, circulating tumor DNA, Electrical and Electronic Engineering, dPCR, digital PCR, Instrumentation, Instruments & Instrumentation, SNV, single-nucleotide variant, Science & Technology, Ref, reference, Reference capture probes, I, intensity, Target depletion, Chemistry, Analytical, Metals and Alloys, Mut, mutant, Hybridization-based nucleic acid mutation sensors DNA thermodynamics Target depletion Single nucleotide variant Microarray technology Reference capture probes Abbreviations: COSMIC, Catalog, ue Of Somatic Mutations In Cancer, NGS, next generation sequencing, P, probe, DNA, Condensed Matter Physics, S 0 , baseline signal, WT, wild-type, LRG, Locus Reference Genomic, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, EGFR, epidermal growth factor receptor, Hybridization-based nucleic acid mutation, Single nucleotide variant, Chemistry, PCR-METHOD, Physical Sciences, DNA thermodynamics

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dad1bad7d75a270864d151971abdf89Test
https://lirias.kuleuven.be/handle/20.500.12942/702147Test

المؤلفون: Marina Pasca di Magliano, Ben L. Allen, Filip Bednar, Hui-Ju Wen, Yaqing Zhang, Paloma E. Garcia, Howard C. Crawford, Michael K. Scales, Amara Z. Shaikh, Esther Kim, Yara S. El-Tawil, Maeva Adoumie, Deneen M. Wellik

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 581-599 (2020)

مصطلحات موضوعية: 0301 basic medicine, tdTomato, tandem dimer Tomato, Gli1, PDAC, pancreatic ductal adenocarcinoma, Kras, Kirsten rat sarcoma viral oncogene homolog, Pancreatic Intraepithelial Neoplasia, medicine.disease_cause, 0302 clinical medicine, Original Research, education.field_of_study, Lineage-Trace, biology, integumentary system, PSC, pancreatic stellate cell, Gastroenterology, TEM, transmission electron microscope, EGFP, enhanced green fluorescent protein, medicine.anatomical_structure, CreERT, tamoxifen-inducible Cre recombinase, 030211 gastroenterology & hepatology, Pancreas, IHC, immunohistochemistry, myCAF, myofibroblast cancer-associated fibroblast, Population, KPF, Ptf1aFlpO/+, KrasFSF-G12D/+, Trp53FRT-STOP-FRT/+, Cancer-Associated Fibroblasts (CAFs), 03 medical and health sciences, Stroma, GLI1, RTom, Rosa26LSL-tdTomato, Pancreatic cancer, medicine, Humans, IF, immunofluorescence, lcsh:RC799-869, Fibroblast, education, CAF, cancer-associated fibroblast, Hepatology, FlpO, codon-optimized Flp recombinase, KF, Ptf1aFlpO/+, PanIN, pancreatic intraepithelial neoplasia, Fibroblasts, medicine.disease, YFP, yellow fluorescent protein, Pancreatic Neoplasms, 030104 developmental biology, Cancer research, biology.protein, PDGFRβ, platelet-derived growth factor β, lcsh:Diseases of the digestive system. Gastroenterology, Heterogeneity, Carcinogenesis, ⍺SMA, α-smooth muscle actin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bb9a4858459dea9c49e9fd7caeb3bbTest
http://europepmc.org/articles/PMC7399194Test

المؤلفون: Jaw-Yuan Wang, Wei-Chih Su, Hsiang-Lin Tsai, Hsiu-Chung Cheng, Tsung-Kun Chang

المصدر: Translational Oncology, Vol 14, Iss 7, Pp 101089-(2021)
Translational Oncology

مصطلحات موضوعية: Oncology, endocrine system diseases, TCF4, Transcription factor 4, Colorectal cancer, RR, relative risk, Review, I2, I-square, HbA1c, Hemoglobin A1c, ADM, antidiabetic medications, AGEs, advanced glycation end-products, SMAD3, Mothers against decapentaplegic homolog 3, US, United States, Impaired glucose tolerance, ADA, American Diabetes Association, Diabetes mellitus, 0302 clinical medicine, GREM1, Gremlin 1, SEPT9, septin 9, RC254-282, APC, Adenomatous polyposis coli, pCR, pathologic complete response, RFS, recurrence-free survival, Metformin, 030220 oncology & carcinogenesis, CRC, colorectal cancer, TCF7L2, Transcription Factor 7 Like 2, medicine.medical_specialty, CSCs, cancer stem cells, WNT, Wingless-related integration site, mTOR, mammalian target of rapamycin, BMI, Body mass index, GLUT1, glucose transporter 1, STZ, streptozotocin, EHMT2, Euchromatic Histone Lysine Methyltransferase 2, VEGFR2, vascular endothelial growth factor 2, mCRC, metastatic colorectal cancer, 03 medical and health sciences, NIDDM, non-insulin-dependent diabetes mellitus, PFS, Progression-free survival, ERFC, Emerging Risk Factors Collaboration, PKC, protein kinase C, KRAS, Kirsten rat sarcoma viral oncogene homolog, AKT, RAC-alpha serine/threonine-protein kinase, WFS1, Wolframin ER Transmembrane Glycoprotein, IGF, Insulin-Like Growth Factor, nutritional and metabolic diseases, medicine.disease, PPARG, Peroxisome Proliferator Activated Receptor Gamma, 030104 developmental biology, Hyperglycemia, TCF7L2, Oncological outcome, 0301 basic medicine, Cancer Research, TP53, tumor protein p53, FOLFOX, Folinic acid, Fluorouracil, Oxaliplatin, RPG, random plasma glucose, Cancer risk, DNA, deoxyribonucleic acid, DM, diabetes mellitus, HNF1B, Hepatocyte nuclear factor-1-beta, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, HR, hazard ratios, CENTRAL, Cochrane Central Register of Controlled Trials, GWAS, Genome-wide association studies, IGF1, Insulin-Like Growth Factor 1, HBP, hexosamine biosynthetic pathway, medicine.drug, PI3K, Phosphoinositide 3-kinases, KCNQ1, Potassium Voltage-Gated Channel Subfamily Q Member 1, EMT, epithelial mesenchymal transition, CAMK1D, Calcium/Calmodulin Dependent Protein Kinase ID, TTR, the time to recurrence, 2-h PG, 2-h plasma glucose, OS, overall survival, ROS, reactive oxygen species, IGFBPs, insulin-like growth factor-binding protein, Internal medicine, RAS, Rat sarcoma, medicine, FPG, fasting plasma glucose, PI3K/AKT/mTOR pathway, VTI1A, Vesicle Transport Through Interaction With T-SNAREs 1A, U.S.FDA, United States Food and Drug administration, OGTT, Oral Glucose Tolerance Test, business.industry, IGF2BP2, Insulin Like Growth Factor 2 MRNA Binding Protein 2, ACF, aberrant crypt foci, AMPK, Cancer, BMJ, British Medical Journal, CI, confidence interval, OR, odds ratio, AMPK, AMP-activated protein kinase, DKD, diabetic kidney disease, TP53INP1, Tumor Protein P53 Inducible Nuclear Protein 1, 5-FU, 5-fluorouracil, NEJM, The New England Journal of Medicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b748b9c71d9b30a48c845ddaf0de4297Test
https://doi.org/10.1016/j.tranon.2021.101089Test

المؤلفون: Philipp K. Haber, Agrin Moeini, Daniela Sia

المصدر: JHEP Reports

مصطلحات موضوعية: ER, estrogen receptor, ARID1A, Cell of origin, ERBB2/3, Erb-B2 Receptor Tyrosine Kinase 2/3, TP53, Tumor Protein P53, PRKACA/B, Protein Kinase CAMP-Activated Catalytic Subunit Alpha/Beta, Review, Personalized therapy, NA, not applicable, RNF43, Ring Finger Protein 43, Lineage tracing, PIK3CA, Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha, Bioinformatics, medicine.disease_cause, Cholangiocarcinoma, ORR, objective response rate, Immunology and Allergy, iCCA, intrahepatic cholangiocarcinoma, BAP1, CDKN2A/B, cyclin-dependent kinase inhibitor 2A/B, Gastroenterology, TBG, thyroid binding globulin, Genomics, PBG, peribiliary gland, pCCA, perihilar cholangiocarcinoma, BTC, biliary tract cancer, GBC, gallbladder cancer, Biliary tract, CLC, cholangiolocarcinoma, eCCA, extrahepatic cholangiocarcinoma, KRAS, FGFR2, Fibroblast Growth Factor Receptor 2, CK, cytokeratin, DCR, disease control rate, NAFLD, non-alcoholic fatty liver disease, CCA, cholangiocarcinoma, FGFR, fibroblast growth factor receptor, MST1, Macrophage Stimulating 1, NASH, non-alcoholic steatohepatitis, PLC, primary liver cancer, Biliary tract cancers, IDH, isocitrate dehydrogenase, NTRK, Neurotrophic Receptor Tyrosine Kinase 1, Biology, GEMM, genetically engineered mouse models, WHO, World Health Organization, OS, overall survival, PFS, progression- free survival, Prominin-1, HPCs, hepatic progenitor cells, Internal Medicine, medicine, Gallbladder cancer, CoH, Canal of Hering, ARID1A, AT-rich interactive domain-containing protein 1A, Hepatology, BAP1, BRCA1-associated protein 1, PROM1, Prominin 1, mo, months, medicine.disease, KRAS, Kirsten Rat Sarcoma Viral Oncogene Homolog, NR, not reported, NGS, next-generation sequencing, MET, Hepatocyte Growth Factor Receptor, PSC, primary sclerosing cholangitis, SMAD4, SMAD Family Member 4, HCC, hepatocellular carcinoma, BRAF, v-Raf murine sarcoma viral oncogene homolog B, dCCA, distal cholangiocarcinoma

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba037ba710b2d3cec7628aee5054cceTest
https://doi.org/10.1016/j.jhepr.2021.100226Test

المؤلفون: Kyung Soo Lee, Joungho Han, Yeonu Choi, Se-Hoon Lee, Teri J. Franks, Chohee Kim, Joon Young Choi, Hyunjin Park, Hwan-Ho Cho

المصدر: European Journal of Radiology Open
European Journal of Radiology Open, Vol 8, Iss, Pp 100351-(2021)

مصطلحات موضوعية: ICC, Intra-class correlation, medicine.medical_specialty, MRI, Magnetic resonance imaging, MTV, Metabolic tumor volume, Intraclass correlation, R895-920, C-index, Concordance index, RRS, Radiomics risk score, LDA, Low density area, LASSO, Least absolute shrinkage and selection operator, Article, 030218 nuclear medicine & medical imaging, Medical physics. Medical radiology. Nuclear medicine, 03 medical and health sciences, 0302 clinical medicine, Region of interest, PC, Pleomorphic carcinoma, Pleomorphic carcinoma, KRAS, Kirsten rat sarcoma viral oncogene homolog, Medicine, Radiology, Nuclear Medicine and imaging, PET/CT, Positron emission tomography/Computed tomography, CRS, Combined risk score, Lung, Survival analysis, DL, Deep learning, TLG, Total lesion glycolysis, PET-CT, Radiomics, Framingham Risk Score, ISZM, Intensity size zone matrix, business.industry, ROI, Region of interest, SUVmax, Maximum standardized uptake value, Hazard ratio, Prognosis, medicine.disease, HR, Hazard ration, VOI, Volume of interest, Feature (computer vision), 030220 oncology & carcinogenesis, GCLM, Gray-level co-occurrence matrix, SUVavg, Average standardized uptake value, Adenocarcinoma, Non-small cell carcinoma, Radiology, business, SRS, Semantic risk score

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fa61545f0abe8d23f910ae114d871dTest
https://doi.org/10.1016/j.ejro.2021.100351Test

المؤلفون: Lindberg, James M., Newhook, Timothy E., Adair, Sara J., Walters, Dustin M., Kim, Alison J., Stelow, Edward B., Parsons, J. Thomas, Bauer, Todd W.

المصدر: Neoplasia (New York, N.Y.)

مصطلحات موضوعية: RAF, rapidly accelerated fibrosarcoma kinase, Male, pEGFR, phospho-EGFR, Pyridones, Receptor, ErbB-2, PDAC, pancreatic ductal adenocarcinoma, pRTK, phospho–receptor tyrosine kinase, MEK1/2, mitogen-activated protein kinase–ERK kinase1/2, Antineoplastic Agents, Pyrimidinones, Antibodies, Monoclonal, Humanized, Article, Cell Line, Tumor, KRAS, Kirsten rat sarcoma viral oncogene homolog, Animals, Humans, HER2, human epidermal growth factor receptor 2, Phosphorylation, skin and connective tissue diseases, neoplasms, Protein Kinase Inhibitors, PDX, patient-derived xenograft, EGF, epidermal growth factor, pJNK, phospho–c-Jun N-terminal kinase, Panitumumab, Antibodies, Monoclonal, Trastuzumab, FDA, Food and Drug Administration, Xenograft Model Antitumor Assays, EGFR, epidermal growth factor receptor, Tumor Burden, ErbB Receptors, Pancreatic Neoplasms, pHER2, phospho-HER2, Disease Models, Animal, Mutation, Tra + P + T, trametinib plus panitumumab plus trastuzumab, Drug Therapy, Combination, Mitogen-Activated Protein Kinases, Proto-Oncogene Proteins c-akt, Carcinoma, Pancreatic Ductal, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::4d788dcf47398a8be699614200c52cf9Test
http://europepmc.org/articles/PMC4198828Test

المؤلفون: William Pao, Bernard J. Park, Christopher G. Azzoli, Mark G. Kris, Maureen F. Zakowski

المصدر: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 3(1)

مصطلحات موضوعية: Oncology, Lung Neoplasms, Time Factors, Adjuvant chemotherapy, medicine.medical_treatment, Non-small cell lung cancer, Tubulin, Carcinoma, Non-Small-Cell Lung, Stage (cooking), Randomized Controlled Trials as Topic, Clinical Trials as Topic, Intracellular Signaling Peptides and Proteins, Multidrug Resistance-Associated Protein 2, Predictive factor, DNA-Binding Proteins, EGFR (epidermal growth factor receptor), Treatment Outcome, Chemotherapy, Adjuvant, Non small cell, Multidrug Resistance-Associated Proteins, Cyclin-Dependent Kinase Inhibitor p27, medicine.drug, Pulmonary and Respiratory Medicine, medicine.medical_specialty, p27Kip1, Antineoplastic Agents, Proto-Oncogene Proteins p21(ras), Internal medicine, Proto-Oncogene Proteins, medicine, MRP2 (multidrug resistance protein 2), Biomarkers, Tumor, ERCC1 (excision repair cross-complementation group 1), Humans, In patient, Lung cancer, Neoplasm Staging, Cisplatin, Chemotherapy, business.industry, bTubIII (class III beta-tubulin), Molecular markers, Membrane Transport Proteins, Genes, erbB-1, medicine.disease, Endonucleases, Survival Analysis, Surgery, ras Proteins, KRAS (Kirsten rat sarcoma viral oncogene homolog), business, Biomarkers, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a2a1ca39c67a71c9c1be8472ce75e4Test
https://pubmed.ncbi.nlm.nih.gov/18166846Test

المؤلفون: Zhengtao Wang, Lili Ding, Wendong Huang, Li Yang

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 2, Pp 135-144 (2015)

مصطلحات موضوعية: BMI, body mass index, Review, G6Pase, glucose-6-phosphatase, Inflammatory bowel disease, HDL-C, high density lipoprotein cholesterol, SHP, small heterodimer partner, AOM, azoxymethane, AF2, activation domain, ERK, extracellular signal-regulated kinase, Gastrointestinal tract, GPBAR, G protein-coupled BA receptor, MRP2, multidrug resistance-associated protein 2, Glucose homeostasis, General Pharmacology, Toxicology and Pharmaceutics, OSTα, organic solute transporter alpha, BAAT, bile acid-CoA amino acid N-acetyltransferase, LCA, lithocholic acid, NF-κB, nuclear factor-kappa B, FGFR4, fibroblast growth factor receptor 4, CA, cholic acid, Bile acid, IBD, inflammatory bowel disease, HNF4α, hepatic nuclear factor 4α, Type 2 diabetes, TNFα, tumor necrosis factors α, I-BABP, intestinal bile acid-binding protein, FGF19, fibroblast growth factor 19, 3. Good health, Cell biology, PEPCK, phosphoenol pyruvate carboxykinase, DSS, dextrane sodium sulfate, LPL, lipoprotein lipase, FFAs, free fatty acids, NOD, non-obese diabetic, AP-1, activator protein-1, GLUT2, glucose transporter type 2, medicine.medical_specialty, Cell signaling, LRH-1, liver receptor homolog-1, MCA, muricholicacid, medicine.drug_class, CREB, cAMP regulatory element-binding protein, SREBP-1c, sterol regulatory element-binding protein 1c, LBD, ligand binding domain, T2D, type 2 diabetes, Biology, Cholesterol 7 alpha-hydroxylase, UDCA, ursodeoxycholic acid, CDCA, chenodeoxycholic acid, FXR, farnesoid X receptor, VSG, vertical sleeve gastrectomy, Farnesoid X receptor, TNBS, trinitrobenzensulfonic acid, Internal medicine, FXRE, farnesoid X receptor response element, medicine, BAAT, GSK3, glycogen synthase kinase 3, KRAS, Kirsten rat sarcoma viral oncogene homolog, GLP-1, glucagon-like peptide 1, FABP6, fatty acid-binding protein subclass 6, BSEP, bile salt export pump, CD, Crohn׳s disease, ASBT, apical sodium-dependent bile salt transporter, PGC-1α, peroxisome proliferators-activated receptor γ coactivator protein-1α, BAs, bile acids, lcsh:RM1-950, FGF19, BACS, bile acid-CoA synthetase, STAT3, signal transducers and activators of transcription 3, CYP7A1, cholesterol 7α-hydroxylase, KLF11, Krüppel-like factor 11, Colorectal cancer, IL-1, interleukin 1, Bile acids, UC, ulcerative colitis, lcsh:Therapeutics. Pharmacology, Endocrinology, Nuclear receptor, Apo, apolipoprotein, DCA, deoxycholic acid, DBD, DNA binding domain, ANGTPL3, angiopoietin-like protein 3, db/db, diabetic mice, TLCA, taurolithocholic acid, GPCRs, G protein-coupled receptors, NRs, nuclear receptors, OSTβ, organic solute transporter beta, 6-ECDCA, 6α-ethyl-chenodeoxycholic acid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32af3a3fcea93a38dfa12c2417846aeTest