المؤلفون: Patibandla, Chinmai, van Aalten, Lidy, Dinkova-Kostova, Albena T., Honda, Tadashi, Cuadrado, Antonio, Fernández-Ginés, Raquel, McNeilly, Alison D., Hayes, John D., Cantley, James, Sutherland, Calum

المصدر: Patibandla , C , van Aalten , L , Dinkova-Kostova , A T , Honda , T , Cuadrado , A , Fernández-Ginés , R , McNeilly , A D , Hayes , J D , Cantley , J & Sutherland , C 2024 , ' Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells ' , Redox Biology , vol. 71 , 103117 . https://doi.org/10.1016/j.redox.2024.103117Test

مصطلحات موضوعية: NRF2, GSK3, β-TrCP, β cells, Islets, NRF2(NF-E2 p45-related factor-2), (NF-E2 p45-related factor-2), KEAP1(Kelch-like ECH-associated protein-1), (Kelch-like ECH-associated protein-1), Glycogen synthase kinase-3(GSK3), (GSK3), β-TrCP(beta-transducin repeat-containing protein), (beta-transducin repeat-containing protein), /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/067ddea9-1af7-483f-89f3-dc2fb439c384Test

الإتاحة: https://doi.org/10.1016/j.redox.2024.103117Test
https://discovery.dundee.ac.uk/en/publications/067ddea9-1af7-483f-89f3-dc2fb439c384Test
https://discovery.dundee.ac.uk/ws/files/119911305/1-s2.0-S2213231724000934-main_1_.pdfTest
http://www.scopus.com/inward/record.url?scp=85187578985&partnerID=8YFLogxKTest
https://www.sciencedirect.com/science/article/pii/S2213231724000934Test

المؤلفون: Jephte Y. Akakpo, Qingyun Bai, Xiao Yang, Li Yang, Thomas Rülicke, Lili Ji, Kurt Zatloukal, Wen-Xing Ding, Hong-Min Ni, Hui Qian, Hartmut Jaeschke

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3791-3805 (2021)

مصطلحات موضوعية: WT, wild type, 4EBP-1, translational initiation factor 4E binding protein-1, Macrophage, S6, ribosomal protein S6 kinase, NAC, N-acetylcysteine, Mitochondrion, LC3, microtubule-associated light chain 3, GSH, glutathione, GCL, glutamate cysteine ligase, KEAP1, Kelch-like ECH-associated protein-1, General Pharmacology, Toxicology and Pharmaceutics, Liver injury, KIR, KEAP1-interacting region, medicine.diagnostic_test, biology, digestive, oral, and skin physiology, Platelet, NRF2, nuclear factor erythroid 2-related factor 2, Original Article, DILI, medicine.drug, VWF, von Willebrand factor, medicine.medical_specialty, APAP, acetaminophen, NF-κB, nuclear factor-κB, RM1-950, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, Western blot, Von Willebrand factor, AILI, APAP-induced liver injury, Internal medicine, ALT, alanine aminotransferase, medicine, Autophagy, CYP2E1, cytochrome P450 2E, KC, Kupffer cells, PI3K/AKT/mTOR pathway, NPCs, non-parenchymal cells, Coagulation, APAP-AD, APAP-adducts, KO, knockout, Cell growth, business.industry, NQO1, NADPH quinone dehydrogenase 1, Hepatotoxicity, CLEC-2, C-type lectin-like receptor, medicine.disease, Acetaminophen, Endocrinology, biology.protein, H&E, hematoxylin and eosin, Liver regeneration, Therapeutics. Pharmacology, business, NAPQI, N-acetyl-p-benzoquinone imine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822a9d722ce09297bbb1ac56b38e95adTest
https://pubmed.ncbi.nlm.nih.gov/35024307Test

المؤلفون: Jennifer E. Gallagher, Dorothy Kisielewski, John F. Dillon, Shaun V. Walsh, Diane Cassidy, David J. Harrison, Ritu Sharma, Tadashi Honda, John D. Hayes, Alison D. McNeilly, Michael L.J. Ashford, Albena T. Dinkova-Kostova, Rory J. McCrimmon

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 367-398 (2018)

مصطلحات موضوعية: NQO1, NAD(P)H:quinone oxidoreductase 1, TNF-α, tumor necrosis factor-α, IRE1α, inositol requiring kinase-1α, SCAD, short-chain acyl-CoA dehydrogenase, C/EBP, CCAAT/enhancer-binding protein, PCR, polymerase chain reaction, UPR, unfolded protein response, 0302 clinical medicine, Fibrosis, MGPAT, mitochondrial glycerol-3-phosphate acetyltransferase, ATF4, activating transcription factor-4, DGAT2, diacylglycerol acyltransferase-2, LXRα, liver X receptor α, Glucose homeostasis, eIf2α, eukaryotic translation initiation factor 2A, IKK, IκB kinase, ACOT7, acetyl-CoA thioesterase 7, Original Research, TGFβ, transforming growth factor beta-1, SLC7A11, solute carrier family 7 member 11, GSSG, oxidized glutathione, MTTP, microsomal triglyceride transfer protein, NASH, Gastroenterology, TXN1, thioredoxin-1, 3. Good health, ChREBP, carbohydrate-responsive element-binding protein, 030220 oncology & carcinogenesis, NASH, nonalcoholic steatohepatitis, medicine.medical_specialty, PARP, poly ADP ribose polymerase, qRT-PCR, quantitative reverse transcriptase PCR, GSTM1, glutathione S-transferase Mu-1, GCLC, glutamate-cysteine ligase catalytic, Nrf2, ACACA, acetyl-CoA carboxylase alpha, 03 medical and health sciences, FXR, farnesoid X receptor, Nrf2, NF-E2 p45-related factor 2, COX2, cyclooxygenase-2, Keap1, Kelch-like ECH-associated protein-1, PPARα, peroxisome proliferator-activated receptor α, PTT, pyruvate tolerance test, HMOX1, heme oxygenase-1, RC, regular chow, p58IPK, p58 inhibitor of the PKR kinase, medicine.disease, TBE-31, 030104 developmental biology, Endocrinology, COL1A1, collagen, type I, alpha-1, Unfolded protein response, CAT, catalase, 0301 basic medicine, PDI, protein disulfide isomerase, GSH, reduced glutathione, FASN, fatty acid synthase, BCL-2, B-cell lymphoma, MPO, myeloperoxidase, AP-1, activator protein 1, DMSO, dimethyl sulfoxide, medicine.disease_cause, SHP, small heterodimer partner, CDDO, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid, CHOP, C/EBP homologous protein, TXNRD1, thioredoxin reductase-1, HF30Fr, high-fat diet with 30% fructose in drinking water, IκB, inhibitor of NF-κB, SFN, sulforaphane, ADRP, adipose differentiation-related protein, NAS, NAFLD activity score, GPX2, glutathione peroxidase-2, Chemistry, MCP-1, monocyte chemotactic protein-1, XBP1, X-box binding protein-1, SREBP-1c, sterol regulatory element-binding protein-1c, Lipogenesis, GTT, glucose tolerance test, PERK, PRK-like endoplasmic reticulum kinase, PTGR1, prostaglandin reductase-1, GSTA4, glutathione S-transferase Alpha-4, medicine.symptom, NAFLD, non-alcoholic fatty liver disease, α-SMA, alpha smooth muscle actin, ACOX2, acetyl-CoA oxidase 2, HFFr, high-fat diet with fructose in drinking water, NF-κB, nuclear factor-κB, GCLM, glutamate-cysteine ligase modifier, Inflammation, JNK1, c-Jun N-terminal kinase 1, CD36, cluster of differentiation 36, ER, endoplasmic reticulum, Insulin resistance, HF, high-fat, HF55Fr, high-fat diet with 55% fructose in drinking water, Internal medicine, ATF6, activating transcription factor-6, medicine, ApoB, apolipoprotein B, lcsh:RC799-869, CES1G, carboxylesterase 1g, ITT, insulin tolerance test, MCD, methionine- and choline-deficient, ACLY, ATP citrate lyase, Hepatology, SCD1, stearoyl-CoA desaturase-1, NOS2, nitric oxide synthase-2, PRDX6, peroxiredoxin 6, PPARγ, peroxisome proliferator-activated receptor γ, BIP, binding immunoglobulin protein, H&E, hematoxylin and eosin, lcsh:Diseases of the digestive system. Gastroenterology, Steatosis, CPT1A, carnitine palmitoyltransferase 1a, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdd8de56b5ba950a8c970d72cce7012Test
https://doi.org/10.1016/j.jcmgh.2017.11.016Test

المؤلفون: Zhengtao Wang, Yuchen Sheng, Zhanxia Hao, Lili Ji, Xiaoqi Jing, Zhenlin Huang, Jiaqi Zhang

المصدر: Redox Biology
Redox Biology, Vol 22, Iss, Pp-(2019)

مصطلحات موضوعية: 0301 basic medicine, Male, Models, Molecular, MDA, malondialdehydeand, Nrf2, Nuclear factor erythroid 2-related factor 2, GSH, reduced glutathione, Clinical Biochemistry, Hepatic Veno-Occlusive Disease, Molecular Conformation, MPO, myeloperoxidase, HO-1, heme oxygenase 1, Pharmacology, HSOS, Biochemistry, Antioxidants, Catechin, Liver disease, chemistry.chemical_compound, H2DCFDA, 2′-7′-dichlorodihydrofluorescein diacetate, Mice, 0302 clinical medicine, lcsh:QH301-705.5, lcsh:R5-920, Monocrotaline, biology, (-)-Epicatechin, HSCT, hematopoietic stem-cell transplantation, EPI, (-)-epicatechin, TBA, bile acids, DILI, drug-induced liver injury, Liver, Myeloperoxidase, LPO, lipid peroxidation, Signal transduction, HSP60, heat shock protein 60, Inflammation Mediators, lcsh:Medicine (General), Oxidation-Reduction, Research Paper, Signal Transduction, ALT/AST, alanine/aspartate aminotransferases, MCT, monocrotaline, Bilirubin, TBil, total bilirubin, NF-E2-Related Factor 2, H&E, hematoxylin-eosin, HSOS, hepatic sinusoidal obstruction syndrome, Mice, Transgenic, Oxidative phosphorylation, Nrf2, 03 medical and health sciences, Structure-Activity Relationship, ROS, reactive oxygen species, Heat shock protein, Keap1, kelch-like ECH-associated protein-1, GST, glutathione-S-transferase, medicine, Animals, GCLC, catalytic subunit of glutamate-cysteine ligase, TALEN, transcription activator-like effector nucleases, HPAs, hepatotoxic pyrrolizidine alkaloids, MMP-9, metalloproteinase-9, GCLM, modify subunit of glutamate-cysteine ligase, Organic Chemistry, Chaperonin 60, medicine.disease, NQO1, NAD(P)H: quinone oxidoreductase 1, KEAP1, Rats, HSECs, hepatic sinusoidal endothelial cells, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, NFκB, nuclear factor κB, lcsh:Biology (General), chemistry, i.g., intragastrical administration, biology.protein, MOF, multi-organ failure, NAFLD, nonalcoholic fatty liver disease, Reactive Oxygen Species, 030217 neurology & neurosurgery, TBIL, Biomarkers, NFκB

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10399ed0ce5ab7a59c41310ef32ed9c1Test
http://europepmc.org/articles/PMC6395886Test

المؤلفون: Fatima Rizvi, Sanjay Krishna, Alpana Mathur, Mohammad Imran Siddiqi, Poonam Kakkar

المصدر: Redox Biology

مصطلحات موضوعية: Male, GSSG, glutathione disulfide, Nrf2, Nuclear factor erythroid 2-related factor 2, Clinical Biochemistry, Drug Evaluation, Preclinical, tBHP, tert-butyl hydroperoxide, Morin, medicine.disease_cause, environment and public health, Biochemistry, GST, glutathione S-transferase, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, chemistry.chemical_compound, PHLPP2, Fyn kinase, Catalytic Domain, Phosphoprotein Phosphatases, GSH, glutathione, DCFH-DA, 2′,7′-dichlorofluorescein diacetate, GR, glutathione reductase, Cells, Cultured, Membrane Potential, Mitochondrial, HO1, heme oxygenase 1, GPx, glutathione peroxidase, Protein Stability, ELISA, enzyme-linked immunosorbent assay, Analgesics, Non-Narcotic, respiratory system, NQO1, NAD(P)H quinine oxidoreductase 1, Cytoprotection, Cell biology, Molecular Docking Simulation, FITC, fluorescein isothiocyanate, Signal transduction, AIF, apoptosis inducing factor, Protein Binding, Research Paper, Transcriptional Activation, PVDF, polyvinylidene fluoride, JC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolyl carbocyanine iodide, NF-E2-Related Factor 2, Primary Cell Culture, APAP, acetaminophen, SEM, standard error of the mean, digestive system, Nrf2, ROS, reactive oxygen species, FYN, medicine, Animals, Rats, Wistar, ARE, antioxidant redox element, Keap1, Kelch-like ECH-associated protein-1, Protein kinase B, Acetaminophen, Flavonoids, GAPDH, glyceraldehyde phosphate dehydrogenase, Organic Chemistry, Glutathione, TrxRed, thioredoxin reductase, KEAP1, chemistry, siRNA, small interfering RNA, Oxidative stress, Hepatocytes, Flavonoid, PHLPP2, PH-domain and Leucine rich repeat protein phosphatase 2, DHE, dihydroethidium

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0622271688b886a27ae2c0e62d3ec8Test
https://doi.org/10.1016/j.redox.2015.10.002Test

المؤلفون: Holly, Robertson, John D, Hayes, Calum, Sutherland

المصدر: Biochemical Pharmacology

مصطلحات موضوعية: Proteasome Endopeptidase Complex, CRY, cryptochrome, REDD1, regulated in development and DNA damage responses-1, ARE, antioxidant response element, Article, PRLr, prolactin receptor, HECT, homologous to the E6AP carboxyl terminus, RING, really interesting new gene, Glycogen Synthase Kinase 3, LiCl, Lithium Chloride, PI3K, phosphatidylinositol 3 kinase, TAZ, transcriptional co-activator with PDZ, binding motif also known as WWTR1, Animals, Humans, KEAP1, Kelch-like ECH-associated protein-1, ComputingMethodologies_COMPUTERGRAPHICS, LATS, large tumour suppressor, PAPC, paraxial protocadherin, PPase, phosphatase, SCF, SKP1, cullin 1, F box protein, Ubiquitination, FGD, faciogenital dysplasia, PR-A, progesterone receptor-A, CKI, casein kinase-1, CHD, chromatin helicase DNA-binding factor, AMPK, AMP-activated protein kinase, VEGFR, vascular endothelial growth factor receptor, JNK, Jun N-terminal kinase, LPCAT, LysophosphatidylcholineAcyltransferase, β-TrCP, beta-transducin repeat containing protein, NRF2, nuclear factor-erythroid 2 p45-related factor 2, RTK, receptor tyrosine kinase, EMT, epithelial-mesenchymal transition, Protein Binding, Signal Transduction, GSK3, Glycogen Synthase Kinase-3, RASSF, Ras association (RalGDS/AF-6) domain family member

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::cf6a12a6098e6b6d178ba6ee2a478676Test
https://pubmed.ncbi.nlm.nih.gov/29102676Test