التفاصيل البيبلوغرافية
العنوان:
Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1–3 Infections
المؤلفون:
Julia Dietz , Ulrich Spengler , Beat Müllhaupt , Julian Schulze zur Wiesch , Felix Piecha , Stefan Mauss , Barbara Seegers , Holger Hinrichsen , Christoph Antoni , Perdita Wietzke-Braun , Kai-Henrik Peiffer , Annemarie Berger , Katrin Matschenz , Peter Buggisch , Johanna Backhus , Eugen Zizer , Tobias Boettler , Christoph Neumann-Haefelin , David Semela , Rudolf Stauber , Thomas Berg , Christoph Berg , Stefan Zeuzem , Johannes Vermehren , Christoph Sarrazin , J. Balavoine , E. Giostra , M. Berning , J. Hampe , A. De Gottardi , A. Rauch , N. Semmo , T. Discher , J. Trauth , J. Fischer , M. Gress , R. Günther , H. Heinzow , J. Schmidt , A. Herrmann , A. Stallmach , G. Hilgard , K. Deterding , C.M. Lange , S. Ciesek , H. Wedemeyer , D. Hoffmann , H. Klinker , P. Schulze , F. Kocheise , M. Müller-Schilling , A. Kodal , A. Kremer , M. Ganslmayer , J. Siebler , F. Lammert , J. Rissland , M. Löbermann , T. Götze , A. Canbay , A. Lohse , J. von Felden , S. Jordan , A. Maieron , D. Moradpour , J.-P. Chave , C. Moreno , T. Müller , M. Muche , H.-J. Epple , K. Port , T. von Hahn , M. Cornberg , M. Manns , L. Reinhardt , V. Ellenrieder , J. Rockstroh , J. Schattenberg , M. Sprinzl , P. Galle , E. Roeb , M. Steckstor , W. Schmiegel , N.H. Brockmeyer , T. Seufferlein , W. Stremmel , B. Strey , R. Thimme , A. Teufel , R. Vogelmann , M. Ebert , K. Tomasiewicz , C. Trautwein , F. Tacke , T. Koenen , T. Weber , R. Zachoval , J. Mayerle , B. Raziorrouh , W. Angeli , S. Beckebaum , C. Doberauer , E. Durmashkina , A. Hackelsberger , A. Erhardt , A. Garrido-Lüneburg , H. Gattringer , D. Genné , M. Gschwantler , F. Gundling , S. Hametner , R. Schöfl , C. Hartmann , T. Heyer , C. Hirschi , A. Jussios , S. Kanzler , N. Kordecki , M. Kraus , U. Kullig , S. Wollschläger , L. Magenta , B. Terziroli Beretta-Piccoli , M. Menges , L. Mohr , K. Muehlenberg , C. Niederau , B. Paulweber , A. Petrides , M. Pinkernell , R. Piso , W. Rambach , M. Reiser , B. Riecken , A. Rieke , J. Roth , M. Schelling , P. Schlee , A. Schneider , D. Scholz , E. Schott , M. Schuchmann , U. Schulten-Baumer , A. Seelhoff , A. Stich , F. Stickel , J. Ungemach , E. Walter , A. Weber , T. Winzer , W. Abels , M. Adler , F. Audebert , C. Baermann , E. Bästlein , R. Barth , K. Barthel , W. Becker , J. Behrends , J. Benninger , F. Berger , D. Berzow , T. Beyer , M. Bierbaum , O. Blaukat , A. Bodtländer , G. Böhm , N. Börner , U. Bohr , B. Bokemeyer , H.R. Bruch , D. Bucholz , O. Burkhard , N. Busch , C. Chirca , R. Delker , J. Diedrich , M. Frank , M. Diehl , A. Dienethal , P. Dietel , N. Dikopoulos , M. Dreck , F. Dreher , L. Drude , K. Ende , U. Ehrle , K. Baumgartl , F. Emke , R. Glosemeyer , G. Felten , D. Hüppe , U. Fischer , D. Frederking , B. Frick , G. Friese , B. Gantke , P. Geyer , H.R. Schwind , M. Glas , T. Glaunsinger , F. Goebel , U. Göbel , B. Görlitz , R. Graf , H. Gruber , G. Härter , M. Herder , T. Heuchel , S. Heuer , K.-H. Höffl , H. Hörster , J.-U. Sonne , W.P. Hofmann , F. Holst , M. Hunstiger , A. Hurst , E. Jägel-Guedes , C. John , M. Jung , B. Kallinowski , B. Kapzan , W. Kerzel , P. Khaykin , M. Klarhof , U. Klüppelberg , K. Klugewitz , B. Knapp , U. Knevels , T. Kochsiek , A. Körfer , A. Köster , M. Kuhn , A. Langekamp , B. Künzig , R. Link , M. Littman , H. Löhr , T. Lutz , G. Knecht , U. Lutz , D. Mainz , I. Mahle , P. Maurer , C. Mayer , V. Meister , H. Möller , R. Heyne , D. Moritzen , M. Mroß , M. Mundlos , U. Naumann , O. Nehls , K.&R. Ningel , A. Oelmann , H. Olejnik , K. Gadow , E. Pascher , J. Petersen , A. Philipp , M. Pichler , F. Polzien , R. Raddant , M. Riedel , S. Rietzler , M. Rössle , W. Rufle , A. Rump , C. Schewe , C. Hoffmann , D. Schleehauf , K.J. Schmidt , W. Schmidt , G. Schmidt-Heinevetter , J. Schmidtler-von Fabris , E. Schnaitmann , L. Schneider , A. Schober , S. Niehaus-Hahn , J. Schwenzer , T. Seidel , G. Seitel , C. Sick , K.G. Simon , D. Stähler , F. Stenschke , H. Steffens , K. Stein , M. Steinmüller , T. Sternfeld , K. Svensson , W. Tacke , G. Teuber , K. Teubner , J. Thieringer , A. Tomesch , U. Trappe , J. Ullrich , G. Urban , S. Usadel , A. von Lucadou , F. Weinberger , M. Werheid-Dobers , P. Werner , T. Winter , E. Zehnter , A. Zipf
المصدر:
Clinical Gastroenterology and Hepatology . 19:195-198.e2
بيانات النشر:
Elsevier BV, 2021.
سنة النشر:
2021
مصطلحات موضوعية:
medicine.medical_specialty , Elbasvir , Daclatasvir , Genotype , Sustained Virologic Response , Sofosbuvir , Combination therapy , Voxilaprevir , Hepacivirus , Viral Nonstructural Proteins , Chronic liver disease , Antiviral Agents , 03 medical and health sciences , chemistry.chemical_compound , 0302 clinical medicine , Internal medicine , Drug Resistance, Viral , medicine , Humans , Hepatology , business.industry , Ribavirin , Liver Neoplasms , Gastroenterology , Hepatitis C, Chronic , medicine.disease , Hepatitis C , chemistry , Grazoprevir , 030220 oncology & carcinogenesis , Retreatment , Drug Therapy, Combination , 030211 gastroenterology & hepatology , business , medicine.drug
الوصف:
Hepatitis C virus infection is causing chronic liver disease, cirrhosis, and hepatocellular carcinoma. By combining direct-acting antivirals (DAAs), high sustained virologic response rates (SVRs) can be achieved. Resistance-associated substitutions (RASs) are commonly observed after DAA failure, and especially nonstructural protein 5A (NS5A) RASs may impact retreatment options.1-3 Data on retreatment of DAA failure patients using first-generation DAAs are limited.4-7 Recently, a second-generation protease- and NS5A-inhibitor plus sofosbuvir (voxilaprevir/velpatasvir/sofosbuvir [VOX/VEL/SOF]) was approved for retreatment after DAA failure.8 However, this and other second-generation regimens are not available in many resource-limited countries or are not reimbursed by regular insurance, and recommendations regarding the selection of retreatment regimens using first-generation DAAs are very important. This study aimed to analyze patients who were re-treated with first-generation DAAs after failure of a DAA combination therapy.
تدمد:
1542-3565
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28dd092318b0adc278e03aae0ae8b84aTest https://doi.org/10.1016/j.cgh.2019.10.051Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....28dd092318b0adc278e03aae0ae8b84a
قاعدة البيانات:
OpenAIRE
