المؤلفون: K. B. Nolop, Garson Tsang, Yan Ma, Heidi Carias, D. Fong, Marika Nespi, Peter Hirth, Rafe Shellooe, Elizabeth A. Burton, Paul S. Lin, Jason Walters, Wayne Spevak, Todd Ewing, Ben Powell, Gideon Bollag, Hanna Cho, Womack Patrick, Bernice Matusow, Ying Zhang, Guoxian Wu, Jiazhong Zhang, Hamid Rezaei, Gary Conard Visor, Hoa Nguyen, Laura Sanftner, Brian L. West, Prabha N. Ibrahim, Gaston Habets, Weiru Wang, Jack Lin, Adhirai Marimuthu, James Tsai, Chao Zhang, Songyuan Shi, Emily Light

المصدر: Nature. 526:583-586

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, MAPK/ERK pathway, Cell signaling, Indoles, MAP Kinase Signaling System, Biology, Heterocyclic Compounds, 2-Ring, Models, Biological, Receptor tyrosine kinase, Mice, Cell Line, Tumor, Encorafenib, medicine, Animals, Humans, HRAS, Vemurafenib, Protein kinase A, Protein Kinase Inhibitors, Sulfonamides, Multidisciplinary, Molecular biology, Enzyme Activation, Genes, ras, Mutation, biology.protein, Cancer research, Female, Mitogen-Activated Protein Kinases, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295d12d8d17d3f824dfd2e4bd4b36deaTest
https://doi.org/10.1038/nature14982Test

المؤلفون: K. B. Nolop, Keith T. Flaherty, Jeffrey A. Sosman, Paul B. Chapman, Grant A. McArthur, Patrick Hwu, Mark Shackleton, Antoni Ribas, Igor Puzanov, Ravi K. Amaravadi, Kevin B. Kim, Bartosz Chmielowski, Paul S. Lin

المصدر: European journal of cancer (Oxford, England : 1990), vol 51, iss 11

مصطلحات موضوعية: Male, Oncology, Cancer Research, Tumour regression, Skin Neoplasms, Indoles, BRAF inhibitor, 80 and over, Young adult, Vemurafenib, Melanoma, Cancer, Aged, 80 and over, Sulfonamides, Middle Aged, Survival Rate, Disease Progression, Public Health and Health Services, Female, Drug, medicine.drug, Proto-Oncogene Proteins B-raf, Adult, medicine.medical_specialty, Clinical Trials and Supportive Activities, Oncology and Carcinogenesis, Metastatic melanoma, Article, Disease-Free Survival, Dose-Response Relationship, Young Adult, Clinical Research, Internal medicine, medicine, Humans, Oncology & Carcinogenesis, Survival rate, Aged, Dose-Response Relationship, Drug, business.industry, Disease progression, medicine.disease, Dermatology, Brain Disorders, business, Progressive disease

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6471687e0652ce3aff078372f57b4473Test
https://doi.org/10.1016/j.ejca.2015.04.010Test

المؤلفون: Fei Su, Matthew J. Klimek, Axel Hauschild, Caroline Robert, Christopher McCormack, Victor G. Prieto, Caroline C. Kim, Olivia Spleiss, Andrew K. Joe, K. B. Nolop, Kerstin Trunzer, James L. Troy, Madeleine Duvic, Joseph F. Grippo, Patricia L. Myskowski, Dirk Schadendorf, B. Nelson, Mario E. Lacouture, Richard J. Lee

المصدر: The Oncologist. 18:314-322

مصطلحات موضوعية: Adult, Male, Cancer Research, medicine.medical_specialty, Keratoacanthoma, Indoles, Skin Neoplasms, Cutaneous squamous cell carcinoma, Adolescent, Treatment outcome, Medizin, Skin Diseases, Young Adult, medicine, Humans, Vemurafenib, Adverse effect, Melanoma, Aged, Randomized Controlled Trials as Topic, Aged, 80 and over, Clinical Trials as Topic, Sulfonamides, business.industry, Neoplasms, Second Primary, Middle Aged, medicine.disease, Dermatology, Treatment Outcome, Oncology, Female, Melanoma and Cutaneous Malignancies, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3b43e749f8433ef55c4c1e6676a2f9Test
https://doi.org/10.1634/theoncologist.2012-0333Test

المؤلفون: Igor Puzanov, Rodney J. Hicks, Ravi K. Amaravadi, K. B. Nolop, Paul B. Chapman, Grant A. McArthur, Antoni Ribas, Jason Callahan, Keith T. Flaherty, Richard J. Lee, Kevin B. Kim, Jeffrey A. Sosman

المصدر: Journal of Clinical Oncology. 30:1628-1634

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, Cancer Research, medicine.medical_specialty, Indoles, Skin Neoplasms, Maximum Tolerated Dose, Mutant, Urology, Standardized uptake value, Drug Administration Schedule, Statistics, Nonparametric, Fluorodeoxyglucose F18, Biomarkers, Tumor, Confidence Intervals, medicine, Humans, Neoplasm Invasiveness, Vemurafenib, Melanoma, Survival analysis, Aged, Monitoring, Physiologic, Neoplasm Staging, Advanced melanoma, Aged, 80 and over, Fluorodeoxyglucose, Sulfonamides, Dose-Response Relationship, Drug, medicine.diagnostic_test, business.industry, Australia, Middle Aged, medicine.disease, Survival Analysis, Early Diagnosis, Treatment Outcome, Oncology, Positron emission tomography, Positron-Emission Tomography, Mutation, Female, business, Nuclear medicine, Follow-Up Studies, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf618ba51a394bd796a18486e8cfff2Test
https://doi.org/10.1200/jco.2011.39.1938Test

المؤلفون: Yu Shyr, Andrew K. Joe, Kevin B. Kim, Grant A. McArthur, Richard F. Kefford, Richard J. Lee, Antoni Ribas, Stergios J. Moschos, Thomas E. Hutson, Jiang Li, Jeffrey A. Sosman, Donald P. Lawrence, Ravi K. Amaravadi, H. Jeffrey Lawrence, Rene Gonzalez, Anna C. Pavlick, Karl D. Lewis, Jeffrey S. Weber, Lynn M. Schuchter, Fei Ye, Igor Puzanov, Peter Hersey, Keith T. Flaherty, Bartosz Chmielowski, K. B. Nolop

المصدر: New England Journal of Medicine. 366:707-714

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, Oncology, Keratoacanthoma, medicine.medical_specialty, Indoles, Dacarbazine, Kaplan-Meier Estimate, Article, chemistry.chemical_compound, Internal medicine, medicine, Clinical endpoint, Humans, Neoplasm Metastasis, Vemurafenib, Melanoma, Aged, Cobimetinib, Sulfonamides, business.industry, Dabrafenib, General Medicine, Middle Aged, medicine.disease, Rash, Surgery, Treatment Outcome, chemistry, Mutation, Disease Progression, Female, medicine.symptom, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50e9fb19e988db3f2994b7a39105541Test
https://doi.org/10.1056/nejmoa1112302Test

المؤلفون: Holly Hilton, Nicholas Otte, Julie S. Hang, Ion Niculescu-Duvaz, Felipe C. Geyer, Lidia Robert, K. B. Nolop, Jorge S. Reis-Filho, Luc Andries, Alfonso Zambon, Gideon Bollag, Rene Gonzalez, Natasha Preece, Paul B. Chapman, Damien Kee, Min Jung Kim, Kerstin Trunzer, Dan Niculescu-Duvaz, Stephen Mok, Brian Lestini, Roger S. Lo, Gaston Habets, Amaya Viros, James L. Troy, Caroline J. Springer, Mark M. Kockx, Yan Ma, Igor Puzanov, Carla Milagre, Robert Hayward, Elizabeth A. Burton, Antoni Ribas, Xiangju Kong, Chao Zhang, Matthew J. Martin, Maryou B K Lambros, Andrew K. Joe, Richard C. Koya, Jeffrey A. Sosman, Olivia Spleiss, Johannes Noe, Bartosz Chmielowski, Hoa Nguyen, Richard J. Lee, Keith T. Flaherty, Richard Marais, Nathalie Dhomen, Hong Yang, Bernice Wong, Qiongqing Wang, Grant A. McArthur, Fei Su, Thomas E. Hutson

المصدر: ResearcherID

مصطلحات موضوعية: Male, Proto-Oncogene Proteins B-raf, Neuroblastoma RAS viral oncogene homolog, Indoles, Skin Neoplasms, Gene Expression, medicine.disease_cause, Mice, chemistry.chemical_compound, CDKN2A, Animals, Humans, Medicine, HRAS, Vemurafenib, Protein Kinase Inhibitors, Aged, Aged, 80 and over, Mitogen-Activated Protein Kinase Kinases, Cobimetinib, Sulfonamides, business.industry, Melanoma, General Medicine, Middle Aged, medicine.disease, Gene Expression Regulation, Neoplastic, Genes, ras, chemistry, Mutation, Carcinoma, Squamous Cell, Cancer research, Female, KRAS, business, Carcinogenesis, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70df6e63cf85087ba092fc0b51ca5514Test
https://doi.org/10.1056/nejmoa1105358Test

المؤلفون: Rachel Langland, Jeanne Tie, Gideon Bollag, Jayesh Desai, Matthew Croxford, Ian T. Jones, K. B. Nolop, Oliver M. Sieber, Daniel McKay, Robert N. Jorissen, Michael Christie, Peter Gibbs, Suzanne Kosmider, Lara Lipton, Antony W. Burgess

المصدر: International Journal of Cancer. 128:2075-2084

مصطلحات موضوعية: Male, Proto-Oncogene Proteins B-raf, Oncology, Cancer Research, medicine.medical_specialty, Pathology, endocrine system diseases, Colorectal cancer, medicine.medical_treatment, Antineoplastic Agents, Kaplan-Meier Estimate, medicine.disease_cause, Targeted therapy, Drug Delivery Systems, Sex Factors, Internal medicine, medicine, Humans, neoplasms, Aged, Neoplasm Staging, Cetuximab, Reverse Transcriptase Polymerase Chain Reaction, business.industry, Age Factors, Cancer, Microsatellite instability, Middle Aged, medicine.disease, Primary tumor, digestive system diseases, Treatment Outcome, Drug Resistance, Neoplasm, Mutation, Female, Microsatellite Instability, KRAS, Colorectal Neoplasms, business, V600E, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b4f2c51619d6c177a513fee0ef5407Test
https://doi.org/10.1002/ijc.25555Test

المؤلفون: K. B. Nolop, Andrew J. Wagner, Gaston Habets, Igor Puzanov, Hoa Nguyen, Vicki L. Keedy, Stephen P. Anthony, Charles Peterfy, John H. Healey, Zev A. Wainberg, Marie J Kim, Arthur P Staddon, Laura Sanftner, Prabha N. Ibrahim, Brian L. West, Allen Lee Cohn, Matt van de Rijn, Paul Severson, Henry H. Hsu, Elizabeth A. Burton, Garson Tsang, Sandra Tong-Starksen, Glen J. Weiss, Adhirai Marimuthu, Gary Conard Visor, Carolyn Gee, William D. Tap, Arun S. Singh, Ramesh K. Ramanathan, Jiazhong Zhang, Eunice L. Kwak, Geoffrey I. Shapiro, Peter Hirth, Paul S. Lin, Gideon Bollag, Ying Zhang, Daniel D. Von Hoff, Chao Zhang, Rafe Shellooe, Bartosz Chmielowski

المصدر: The New England journal of medicine. 373(5)

مصطلحات موضوعية: Adult, Male, Pexidartinib, Aminopyridines, Receptor, Macrophage Colony-Stimulating Factor, Soft Tissue Neoplasms, In situ hybridization, Pharmacology, Crystallography, X-Ray, Tendons, Pharmacokinetics, Drug Discovery, medicine, Humans, Pyrroles, Receptor, Aged, Dose-Response Relationship, Drug, business.industry, Kinase, Giant Cell Tumors, General Medicine, Middle Aged, Blockade, Tumor Burden, Clinical trial, Mechanism of action, Cancer research, Female, medicine.symptom, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990fcac7cd547810299206ca8347a476Test
https://pubmed.ncbi.nlm.nih.gov/31229239Test

المؤلفون: Timothy F. Cloughesy, Joanna J. Phillips, Lakshmi Nayak, Nicholas Butowski, Brian L. West, Arie Perry, Annette M. Molinaro, Henry H. Hsu, Jason T. Huse, Sam Haidar, Michael D. Prados, John de Groot, Antonio Omuro, Adhirai Marimuthu, K. B. Nolop, Keith L. Ligon, Howard Colman, Patrick Y. Wen

المصدر: Neuro-oncology, vol 18, iss 4

مصطلحات موضوعية: 0301 basic medicine, Male, Cancer Research, Phases of clinical research, microglia, Administration, Oral, Aminopyridines, Pharmacology, Cohort Studies, Immunoenzyme Techniques, glioma, Receptors, Tissue Distribution, Cancer, Tumor, Brain Neoplasms, Middle Aged, Prognosis, Tumor Burden, Oncology, Local, Blood-Brain Barrier, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, 6.1 Pharmaceuticals, Administration, Female, Macrophage colony-stimulating factor, Oral, Clinical Trials and Supportive Activities, Oncology and Carcinogenesis, Cmax, Clinical Investigations, Colony stimulating factor 1 receptor, 03 medical and health sciences, Rare Diseases, Pharmacokinetics, Clinical Research, Glioma, PLX3397, medicine, Biomarkers, Tumor, Humans, Pyrroles, Progression-free survival, Oncology & Carcinogenesis, Neoplasm Staging, Surrogate endpoint, business.industry, glioblastoma, Neurosciences, Granulocyte-Macrophage Colony-Stimulating Factor, Evaluation of treatments and therapeutic interventions, CSF1R, medicine.disease, Brain Disorders, Brain Cancer, 030104 developmental biology, Neoplasm Recurrence, Neurology (clinical), Neoplasm Recurrence, Local, business, Glioblastoma, Biomarkers, Follow-Up Studies

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc83ee598fc1e81e462bbc245dc67fbeTest
https://pubmed.ncbi.nlm.nih.gov/26449250Test

المؤلفون: Guoxian Wu, Garson Tsang, Gaston Habets, Chao Zhang, Paul S. Lin, Dean R. Artis, Marika Nespi, Jiazhong Zhang, Elizabeth A. Burton, Hoa Nguyen, Angela Oh, Adhirai Marimuthu, Wayne Spevak, Gideon Bollag, Gregory H Tesch, Rafe Shellooe, Bernice Matusow, Prabha N. Ibrahim, Peter Hirth, Ying Zhang, Brian L. West, Ryan Bremer, Clarence R. Hurt, Kam Y. J. Zhang, Heidi Carias, Ben Powell, K. B. Nolop

مصطلحات موضوعية: Models, Molecular, Indoles, Cell Survival, Protein Conformation, Viral Oncogene, Mutation, Missense, Aminopyridines, Osteoclasts, Inflammation, Biology, Spodoptera, Chromatography, Affinity, Immune system, medicine, Escherichia coli, Human Umbilical Vein Endothelial Cells, Sf9 Cells, Animals, Humans, Pyrroles, Mast Cells, Neoplasm Metastasis, Protein Kinase Inhibitors, Multidisciplinary, Oncogene, Molecular Structure, Oncogene Protein gp140(v-fms), Macrophages, Cancer, Biological Sciences, medicine.disease, Proto-Oncogene Proteins c-kit, Immunology, Cancer cell, Cancer research, medicine.symptom, Crystallization

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13beba63af32ac3d497883ca2b5e3e1Test
https://europepmc.org/articles/PMC3619323Test/