المؤلفون: Seunghun P. Lee, Jenson Qi, Guozhang Xu, Matthew M. Rankin, James Littrell, June Zhi Xu, Ivona Bakaj, Alessandro Pocai

المصدر: Frontiers in Endocrinology, Vol 12 (2021)

مصطلحات موضوعية: GRK2 = G protein–coupled receptor kinase 2, GLP-1, diabetes, obesity, NASH, insulin secretion, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fendo.2021.652628/fullTest; https://doaj.org/toc/1664-2392Test

الوصول الحر: https://doaj.org/article/c5c8decb80f8469c94f501e6c8a341aeTest

المؤلفون: June Zhi Xu, James Littrell, Seunghun Paul Lee, Guozhang Xu, Matthew Rankin, Jenson Qi, Ivona Bakaj, Alessandro Pocai

المصدر: Frontiers in Endocrinology, Vol 12 (2021)
Frontiers in Endocrinology

مصطلحات موضوعية: 0301 basic medicine, obesity, insulin secretion, CKD - chronic kidney disease, G-Protein-Coupled Receptor Kinase 1, Endocrinology, Diabetes and Metabolism, Endogeny, GRK2 = G protein–coupled receptor kinase 2, Eating, Mice, 0302 clinical medicine, Endocrinology, Glucagon-Like Peptide 1, Receptors, Glucagon, Insulin, Phosphorylation, Receptor, beta-Arrestins, Original Research, biology, diabetes, Chemistry, Kinase, digestive, oral, and skin physiology, NASH, Glucagon-like peptide-1, Cell biology, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, endocrine system, Dipeptidyl Peptidase 4, CHO Cells, Carbohydrate metabolism, Glucagon-Like Peptide-1 Receptor, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Islets of Langerhans, Cricetulus, Diabetes Mellitus, Animals, Humans, Renal Insufficiency, Chronic, Dipeptidyl peptidase-4, G protein-coupled receptor, Beta adrenergic receptor kinase, RC648-665, Amides, 030104 developmental biology, Glucose, biology.protein, Calcium, GLP-1, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440f9f5baedcb64f3b7c2909187f7092Test

المؤلفون: Hua-Rong Lu, Ioanna Petrounia, Zhijie Liu, Daniel Jason Krosky, Devine Zheng Huang, Guozhang Xu, John Spurlino, Michael David Gaul, Weixue Wang, An Hermans, June Zhi Xu, Cynthia M. Milligan, Jenson Qi, Renee L. DesJarlais

المصدر: Bioorganicmedicinal chemistry letters. 30(23)

مصطلحات موضوعية: G-Protein-Coupled Receptor Kinase 2, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Downregulation and upregulation, Drug Discovery, medicine, Animals, Humans, Myocytes, Cardiac, Receptor, Molecular Biology, Protein Kinase Inhibitors, G protein-coupled receptor, Enzyme Assays, G protein-coupled receptor kinase, biology, Molecular Structure, 010405 organic chemistry, Chemistry, Kinase, Beta adrenergic receptor kinase, Organic Chemistry, Hit to lead, Adenosine, 0104 chemical sciences, Mice, Inbred C57BL, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, HEK293 Cells, biology.protein, Quinazolines, Molecular Medicine, Phthalazines, medicine.drug, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52110a2ca5137d576a970f201881f77Test
https://pubmed.ncbi.nlm.nih.gov/33038544Test

المؤلفون: Fuyong Du, Gee-Hong Kuo, Yin Liang, Guozhang Xu, Michael David Gaul, Keith T. Demarest, June Zhi Xu

المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127387

مصطلحات موضوعية: Blood Glucose, Halogenation, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, Rats, Sprague-Dawley, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Sodium-Glucose Transporter 1, Glucosides, Sodium-Glucose Transporter 2, In vivo, Microsomes, Drug Discovery, Diabetes Mellitus, Animals, Humans, Hypoglycemic Agents, heterocyclic compounds, Hydroxymethyl, Hexose, Molecular Biology, IC50, chemistry.chemical_classification, 010405 organic chemistry, Organic Chemistry, Glucose transporter, Glucose Tolerance Test, Rats, 0104 chemical sciences, Bioavailability, Mice, Inbred C57BL, Disease Models, Animal, 010404 medicinal & biomolecular chemistry, Postprandial, chemistry, Drug Design, Molecular Medicine, SGLT2 Inhibitor, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e14d3ba29a79979b3a7899ecbf00c8bTest
https://doi.org/10.1016/j.bmcl.2020.127387Test

المؤلفون: Simon A. Hinke, Jose Silva, Guozhang Xu, Michael David Gaul, Seunghun Paul Lee, William V. Murray, Norman D. Huebert, Thomas Kirchner, Gee-Hong Kuo, Fuyong Du, Keith T. Demarest, June Zhi Xu, Yin Liang, Nathaniel H. Wallace

المصدر: Bioorganicmedicinal chemistry letters. 28(21)

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, Sodium, Clinical Biochemistry, Pharmaceutical Science, chemistry.chemical_element, Administration, Oral, Pharmacology, Deoxyglucose, Biochemistry, Diabetes Mellitus, Experimental, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 0302 clinical medicine, Sodium-Glucose Transporter 1, Sodium-Glucose Transporter 2, Diabetes mellitus, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Hydroxymethyl, Molecular Biology, Sodium-Glucose Transporter 2 Inhibitors, Molecular Structure, Chemistry, Organic Chemistry, Glucose transporter, medicine.disease, Rats, Zucker, Macaca fascicularis, 030104 developmental biology, Orally active, Pyran, 030220 oncology & carcinogenesis, Drug Design, Microsomes, Liver, Molecular Medicine, Bioisostere, SGLT2 Inhibitor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b1facca7dd2a8982bfbb262f059233Test
https://pubmed.ncbi.nlm.nih.gov/30268701Test