نتائج البحث - "Julieann Sludden"

المصدر: Jamieson, D, Griffin, M, Sludden, J, Drew, Y, Cresti, N, Swales, K, Merriman, M, Allen, R, Bevan, P, Buerkle, M, Mala, C, Coyle, V, Rodgers, L, Dean, E, Greystoke, A, Banerji, U, Wilson, R, Evans, J, Anthoney, A, Ranson, M, Boddy, A & Plummer, R 2016, ' A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours ', European Journal of Cancer, vol. 68 . https://doi.org/10.1016/j.ejca.2016.08.026Test
Jamieson, D, Griffin, M J, Sludden, J, Drew, Y, Cresti, N, Swales, K, Merriman, M, Allen, R, Bevan, P, Buerkle, M, Mala, C, Coyle, V, Rodgers, L, Dean, E, Greystoke, A, Banerji, U, Wilson, R H, Evans, T R J, Anthoney, A, Ranson, M, Boddy, A V & Plummer, R 2016, ' A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours ', European Journal of Cancer, vol. 68, pp. 1-10 . https://doi.org/10.1016/j.ejca.2016.08.026Test

مصطلحات موضوعية: Male, Mesothelioma, 0301 basic medicine, Cancer Research, Lung Neoplasms, Esophageal Neoplasms, MAP Kinase Kinase 2, MAP Kinase Kinase 1, Administration, Oral, Uterine Cervical Neoplasms, Mitogen-activated protein kinase kinase, Pharmacology, Cholangiocarcinoma, 0302 clinical medicine, Tandem Mass Spectrometry, Carcinoma, Non-Small-Cell Lung, Neoplasms, Medicine, Chromatography, High Pressure Liquid, Fatigue, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Manchester Cancer Research Centre, Kinase, MEK inhibitor, Ribosomal Protein S6 Kinases, 70-kDa, Nausea, Middle Aged, Anorexia, Oncology, 030220 oncology & carcinogenesis, Toxicity, Female, Drug Eruptions, Colorectal Neoplasms, pharmacokinetics, Adult, Diarrhea, Maximum Tolerated Dose, Phase 1, optimal biological dose, 03 medical and health sciences, Phase I, Allosteric Regulation, SDG 3 - Good Health and Well-being, Pharmacokinetics, MEK Inhibitor WX-554, pharmacodynamics, Humans, Protein Kinase Inhibitors, Aged, Glycogen Synthase Kinase 3 beta, Performance status, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, Phosphoproteins, Abdominal Pain, Pancreatic Neoplasms, 030104 developmental biology, Bile Duct Neoplasms, Pharmacodynamics, business, Proto-Oncogene Proteins c-akt, Chromatography, Liquid

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cfeb7e3462ba1cdff56aeaf39e4fa01Test
https://doi.org/10.1016/j.ejca.2016.08.026Test

5

Development and validation of a LC-MS/MS method for the quantification of the checkpoint kinase 1 inhibitor SRA737 in human plasma

المؤلفون: Monique Zangarini, Gareth J. Veal, Florence I. Raynaud, Paul W. Jones, David Edwards, Philip Berry, Udai Banerji, Julieann Sludden

المصدر: Bioanalysis. 9(13)

مصطلحات موضوعية: 0301 basic medicine, Coefficient of variation, Clinical Biochemistry, Tandem mass spectrometry, High-performance liquid chromatography, Heterocyclic Compounds, 4 or More Rings, Analytical Chemistry, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Limit of Detection, Tandem Mass Spectrometry, Protein precipitation, Humans, Sample preparation, CHEK1, General Pharmacology, Toxicology and Pharmaceutics, Protein Kinase Inhibitors, Chromatography, High Pressure Liquid, Detection limit, Chromatography, Chemistry, General Medicine, Medical Laboratory Technology, 030104 developmental biology, 030220 oncology & carcinogenesis, Checkpoint Kinase 1, Linear Models, Blood Chemical Analysis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d22677a3300d6a36618dbda6ed5eae2Test
https://pubmed.ncbi.nlm.nih.gov/28692309Test

6

Pharmacogenetic association of MBL2 and CD95 polymorphisms with grade 3 infection following adjuvant therapy for breast cancer with doxorubicin and cyclophosphamide

المؤلفون: Mark Verrill, Johanne Lee, Sara Muro, Julieann Sludden, Nicola Cresti, Alan V. Boddy, Lucie Pouché, James M. Allan, Nicola J. Sunter, MJ Griffin, David Jamieson

المساهمون: Jamieson, David, Sunter, Nicola, Muro, Sara, Pouche, Lucie, Cresti, Nicola, Lee, Johanne, Sludden, Julieann, Griffin, Melanie J, Allan, James M, Verrill, Mark W, Boddy, Alan V

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Neutropenia, Genotype, Breast Neoplasms, Single-nucleotide polymorphism, Infections, Mannose-Binding Lectin, Polymorphism, Single Nucleotide, doxorubicin, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Antineoplastic Combined Chemotherapy Protocols, medicine, Adjuvant therapy, Humans, SNP, fas Receptor, Allele, Cyclophosphamide, Aged, pharmacogenetics, business.industry, Cancer, Middle Aged, medicine.disease, Survival Analysis, Neutrophilia, infection, Minor allele frequency, 030104 developmental biology, cancer chemotherapy drugs, MBL2, Oncology, Chemotherapy, Adjuvant, Doxorubicin, Pharmacogenetics, 030220 oncology & carcinogenesis, Immunology, CD95, Female, cyclophosphamide, medicine.symptom, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54ec9762f253adf7080ed61afc87924Test
https://hdl.handle.net/11541.2/132913Test

7

Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer

المؤلفون: Gordon C Jayson, Gary Acton, Jonathan A. Ledermann, Geoff Hall, Sarah Halford, Martin Highley, Nicola J. Curtin, Ruth Plummer, Julieann Sludden, R.M. Glasspool, David Jamieson, Alan V. Boddy, Zoe Backholer, Daniel Rea, Raffaella Mangano, Yvette Drew, James W. Murray

المساهمون: Drew, Yvette, Ledermann, Jonathan, Hall, Geoff, Rea, Daniel, Glasspool, Ros, Highley, Martin, Jayson, Gordon, Sludden, Julieann, Murray, James, Jamieson, David, Halford, Sarah, Acton, Gary, Backholer, Zoe, Mangano, Raffaella, Boddy, Alan, Curtin, Nicola, Plummer, Ruth

المصدر: British Journal of Cancer
Drew, Y, Ledermann, J, Hall, G, Rea, D, Glasspool, R, Highley, M, Jayson, G, Sludden, J, Murray, J, Jamieson, D, Halford, S, Acton, G, Blackholer, Z, Mangano, R, Boddy, A, Curtin, N & Plummer, R 2016, ' Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer ', Br J Cancer, vol. 114, e21 . https://doi.org/10.1038/bjc.2016.41Test

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Indoles, Poly (ADP-Ribose) Polymerase Inhibitor, Cohort Studies, chemistry.chemical_compound, Prostate cancer, 0302 clinical medicine, Tissue Distribution, mutation carriers, Ovarian Neoplasms, Manchester Cancer Research Centre, BRCA1 Protein, Middle Aged, Prognosis, poly(ADP-ribose) polymerase, polymerase, ovarian cancer, Oncology, 030220 oncology & carcinogenesis, Female, Corrigendum, Adult, Heterozygote, Poly ADP ribose polymerase, Breast Neoplasms, Poly(ADP-ribose) Polymerase Inhibitors, Drug Administration Schedule, Olaparib, Young Adult, 03 medical and health sciences, Germline mutation, Breast cancer, breast cancer, medicine, Humans, Rucaparib, Germ-Line Mutation, Aged, Neoplasm Staging, BRCA2 Protein, Dose-Response Relationship, Drug, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, PARP inhibition, BRCA mutation, medicine.disease, rucaparib, 030104 developmental biology, chemistry, Immunology, Cancer research, business, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5e00f287a35b93593ae9c8ca970c12Test
https://hdl.handle.net/11541.2/133063Test

8

A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours

المؤلفون: Martin Eatock, Ruth Plummer, Chris J. Ottley, H. Calvert, D.G. Pearson, MJ Griffin, Kazunori Kataoka, T. Nishiya, Michael J. Tilby, Richard H. Wilson, Julieann Sludden, Yasuhiro Matsumura, Alan V. Boddy

المساهمون: Plummer, R, Wilson, RH, Calvert, H, Boddy, AV, Griffin, M, Sludden, J, Tilby, MJ, Eatock, M, Pearson, DG, Ottley, CJ, Matsumura, Y, Kataoka, K, Nishiya, T

المصدر: British Journal of Cancer

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbcee433075247086018ecced5f56daTest
https://doi.org/10.1038/bjc.2011.6Test

9

Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide

المؤلفون: MJ Griffin, Julieann Sludden, Alan V. Boddy, David Jamieson, Mark Verrill, Johanne Bray, Michael Cole

المساهمون: Bray, J, Sludden, J, Griffin, MJ, Cole, M, Verrill, M, Jamieson, D, Boddy, AV

المصدر: British Journal of Cancer

مصطلحات موضوعية: Oncology, Cancer Research, Pharmacology, Biomarkers, Pharmacological, chemistry.chemical_compound, Gene Frequency, Antineoplastic Combined Chemotherapy Protocols, polycyclic compounds, Medicine, skin and connective tissue diseases, pharmacogenetics, Carcinoma, Ductal, Breast, Middle Aged, Nitrogen mustard, Toxicity, Female, Aryl Hydrocarbon Hydroxylases, Breast disease, medicine.drug, medicine.medical_specialty, ATP Binding Cassette Transporter, Subfamily B, Drug-Related Side Effects and Adverse Reactions, Genotype, Organic Cation Transport Proteins, Cyclophosphamide, Breast Neoplasms, Polymorphism, Single Nucleotide, doxorubicin, breast cancer, Breast cancer, Internal medicine, Biomarkers, Tumor, Humans, Doxorubicin, ATP Binding Cassette Transporter, Subfamily B, Member 1, Retrospective Studies, business.industry, Cancer, Oxidoreductases, N-Demethylating, medicine.disease, Survival Analysis, Cytochrome P-450 CYP2B6, chemistry, Drug Resistance, Neoplasm, cyclophosphamide, Translational Therapeutics, business, Pharmacogenetics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ccc0b131cc452f9650132e5ba1a8edfTest
https://doi.org/10.1038/sj.bjc.6605587Test

10

Efficacy of PARP inhibitor rucaparib in orthotopic glioblastoma xenografts Is limited by ineffective drug penetration into the central nervous system

المؤلفون: Karen E. Parrish, William F. Elmquist, Nicola J. Curtin, Alan V. Boddy, Rajendar K. Mittapalli, Ling Cen, David Calligaris, Brett L. Carlson, Jann N. Sarkaria, James W. Murray, Mark A. Schroeder, Sani H. Kizilbash, Nathalie Y. R. Agar, Julieann Sludden

المساهمون: Parrish, Karen E, Cen, Ling, Murray, James, Calligaris, David, Kizilbash, Sani, Mittapalli, Rajendar K, Carlson, Brett L, Schroeder, Mark A, Sludden, Julieann, Boddy, Alan V, Agar, Nathalie YR, Curtin, Nicola J, Elmquist, William F, Sarkaria, Jann N

مصطلحات موضوعية: Central Nervous System, Cancer Research, tumor, ATP Binding Cassette Transporter, Subfamily B, Indoles, Dacarbazine, Cell, temozolomide, Pharmacology, Poly(ADP-ribose) Polymerase Inhibitors, Article, Madin Darby Canine Kidney Cells, chemistry.chemical_compound, Mice, Dogs, Pharmacokinetics, Cell Line, Tumor, Temozolomide, pharmacodynamics, Medicine, ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Humans, xenograft, Rucaparib, Mice, Knockout, business.industry, PARP inhibition, Xenograft Model Antitumor Assays, rucaparib, In vitro, medicine.anatomical_structure, chemistry, Oncology, PARP inhibitor, Drug delivery, ATP-Binding Cassette Transporters, business, Glioblastoma, pharmacokinetics, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b32b021d1a9031d0f248faf3531de41Test
https://hdl.handle.net/11541.2/133074Test

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