دورية أكاديمية
The Impact of Unilateral 90Y-radioembolization on Functional Changes in the Contralateral Hepatic Lobe
| العنوان: | The Impact of Unilateral 90Y-radioembolization on Functional Changes in the Contralateral Hepatic Lobe |
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| المؤلفون: | Benjamin Garlipp, MD, Holger Amthauer, MD, Dennis Kupitz, DMP, Oliver S. Grosser, DMP, Julian Jürgens, MD, Robert Damm, MD, Maciej Powerski, MD, Matthias Fabritius, MD, Osman Oecal, MD, Patrick Stuebs, MD, Christoph Benckert, MD, Ricarda Seidensticker, MD, Jens Ricke, MD, Maciej Pech, MD, Max Seidensticker, MD |
| المصدر: | Annals of Surgery Open, Vol 2, Iss 3, p e095 (2021) |
| بيانات النشر: | Wolters Kluwer Health, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Surgery |
| مصطلحات موضوعية: | Surgery, RD1-811 |
| الوصف: | Objectives:. To investigate how metabolic function of the contralateral liver lobe is affected by unilateral radioembolization (RE), and to compare the changes in volume and metabolic function. Background:. Unilateral RE induces contralateral liver hypertrophy, but it is unknown if metabolic liver function improves in line with volume increases. Methods:. This prospective open-label, nonrandomized, therapy-optimizing study included all consecutive patients undergoing right-sided or sequential 90Y-RE for liver malignancies without underlying liver disease or biliary obstruction at a single center in Germany. Magnetic resonance imaging volumetry and hepatobiliary scintigraphy were performed immediately before RE and approximately 6 weeks after RE. Results:. Twenty-three patients were evaluated (11 metastatic colorectal cancer, 4 cholangiocellular carcinoma, 3 metastatic breast cancer, 1 each of metastatic neuroendocrine tumor, hepatocellular carcinoma, renal cell carcinoma, oesophageal cancer, pancreatic ductal adenocarcinoma). In the untreated contralateral left liver lobe, mean (SD) metabolic function significantly increased from 1.34 (0.76) %/min/m2 at baseline to 1.56 (0.75) %/min/m2 6 weeks after RE (P = 0.024). The mean (SD) functional volume (liver volume minus tumor volume) of the left liver lobe significantly increased from baseline (407.3 [170.3] mL) to follow-up (499.1 [209.8] mL; P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2691-3593 00000000 |
| العلاقة: | http://journals.lww.com/10.1097/AS9.0000000000000095Test; https://doaj.org/toc/2691-3593Test |
| DOI: | 10.1097/AS9.0000000000000095 |
| الوصول الحر: | https://doaj.org/article/5ea7610fd6604ea6b1f00741352c8014Test |
| رقم الانضمام: | edsdoj.5ea7610fd6604ea6b1f00741352c8014 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26913593 00000000 |
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| DOI: | 10.1097/AS9.0000000000000095 |