Neuropeptide Y and Y2‐receptor are involved in development of diabetic retinopathy and retinal neovascularization
| العنوان: | Neuropeptide Y and Y2‐receptor are involved in development of diabetic retinopathy and retinal neovascularization |
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| المؤلفون: | Katja Kaipio-Salmi, Ulriikka Jaakkola, Rosemary D. Higgins, Jaana Kallio, Markku Koulu, Zofia Zukowska, Sharareh Movafagh, Helena Seppälä, Yixun Geng, Matti K. Karvonen, Ullamari Pesonen, E. Vainio-Jylhä, Jukka Tuohimaa, Matti Pöllönen, Edward Lee |
| المصدر: | Annals of Medicine. 36:232-240 |
| بيانات النشر: | Informa UK Limited, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Type 2 diabetes, Retinal Neovascularization, Mice, Internal medicine, Diabetes mellitus, medicine, Animals, Humans, Neuropeptide Y, Receptor, Aged, Retina, Diabetic Retinopathy, business.industry, General Medicine, Diabetic retinopathy, Middle Aged, medicine.disease, Neuropeptide Y receptor, Rats, Receptors, Neuropeptide Y, Diabetes Mellitus, Type 1, Endocrinology, medicine.anatomical_structure, Diabetes Mellitus, Type 2, Knockout mouse, Female, business, Retinopathy |
| الوصف: | Neuropeptide Y is a sympathetic neurotransmitter, a potent endothelium-derived angiogenic factor and a vascular mitogen. We have studied the role of the functional leucine7 to proline7 polymorphism of the signal peptide region of preproneuropeptide Y (prepro-NPY) as a genetic susceptibility factor for diabetic retinopathy. In addition, we investigated the role of the NPY Y2-receptor as a putative mediator of angiogenic NPY signaling in the retina.Frequencies of proline7 (Pro7) carriers in the prepro-NPY were determined in type 1 and type 2 diabetes patients having retinopathy, in type 2 diabetes patients without retinopathy and in healthy control subjects. The role of Y2-receptor in hyperoxemia-induced retinal neovascularization was investigated in Y2-receptor knockout mice (Y2-/-) and in rats administered Y2-receptor mRNA antisense oligonucleotide.The carriers having Pro7 in the preproNPY are markedly over-represented among type 2 diabetes patients with retinopathy compared to type 2 diabetes patients without retinopathy and to the population control. Neonatal exposure to hyperoxia resulted in development of retinal neovascularization that was prevented in Y2(-1-) -mice, and significantly inhibited in rats treated with the Y2-receptor antisense oligonucleotide.NPY and Y2-receptor play important roles in diabetic retinopathy and retinal neovascularization and are thus potential new targets for drug molecules for treatment of retinopathy. |
| تدمد: | 1365-2060 0785-3890 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2976861a8d81efc29e4792d9995a12aTest https://doi.org/10.1080/07853890410031236Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f2976861a8d81efc29e4792d9995a12a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652060 07853890 |
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