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1دورية أكاديمية
المؤلفون: Ludovico Pipitò, Christopher A. Reynolds, Juan Carlos Mobarec, Owen Vickery, Giuseppe Deganutti
المصدر: Biomolecules, Vol 12, Iss 11, p 1607 (2022)
مصطلحات موضوعية: SARS-CoV-2, spike protein ACE-2, molecular dynamics, supervised molecular dynamics, binding pathway, Microbiology, QR1-502
وصف الملف: electronic resource
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2دورية أكاديمية
المصدر: PLoS Computational Biology, Vol 7, Iss 10, p e1002193 (2011)
مصطلحات موضوعية: Biology (General), QH301-705.5
وصف الملف: electronic resource
العلاقة: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22022248/pdf/?tool=EBITest; https://doaj.org/toc/1553-734XTest; https://doaj.org/toc/1553-7358Test
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المؤلفون: Giovanna Ghirlanda, Patrick M. Sexton, Juliana E. Milburn, Arthur Christopoulos, Maoqing Dong, Denise Wootten, Christopher A. Reynolds, Rafael Alcala-Torano, Juan Carlos Mobarec, Carolyn E. Clark, Sweta R. Raval, Kaleeckal G. Harikumar, Laurence J. Miller
المصدر: Biochem Pharmacol
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Protein Conformation, alpha-Helical, Peptide, CHO Cells, Ligands, Biochemistry, Partial agonist, Article, Glucagon-Like Peptide-1 Receptor, Receptors, G-Protein-Coupled, Receptors, Gastrointestinal Hormone, 03 medical and health sciences, 0302 clinical medicine, Cricetulus, Secretin, Animals, Humans, Amino Acid Sequence, Receptor, G protein-coupled receptor, Pharmacology, chemistry.chemical_classification, Alanine, Binding Sites, Biological activity, Receptors, Calcitonin, Ligand (biochemistry), 030104 developmental biology, chemistry, Competitive antagonist, 030220 oncology & carcinogenesis, Drug Design, Biophysics, Secretin receptor, Peptides, Hydrophobic and Hydrophilic Interactions, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1704710372a14db4f7d2b7f9b7a4caTest
https://europepmc.org/articles/PMC7299832Test/ -
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المؤلفون: Caroline A. Hick, Juan Carlos Mobarec, Patrick M. Sexton, Thomas P. Sakmar, Cassandra Koole, Christopher A. Reynolds
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, photocross-linking, Peptide, Ligands, Biochemistry, structure-function, 0302 clinical medicine, Cyclic AMP, structural biology, 5-HT5A receptor, Receptor, chemistry.chemical_classification, Molecular Structure, genetic code expansion, Protein Structure and Folding, glucagon-like peptide-1 receptor (GLP-1R), Azides, Ultraviolet Rays, Phenylalanine, Protein domain, G protein-coupled receptor (GPCR), Biology, Molecular Dynamics Simulation, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Structure-Activity Relationship, Protein Domains, Humans, unnatural amino acid, GABBR2, GABBR1, Molecular Biology, G protein-coupled receptor, Binding Sites, peptide hormone, molecular modeling, Venoms, Cell Biology, 030104 developmental biology, HEK293 Cells, Structural biology, chemistry, Diabetes Mellitus, Type 2, Mutagenesis, Mutation, Biophysics, Exenatide, Protein Multimerization, Peptides, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf16e26034aacee8551f6377dd783e8Test
http://europepmc.org/articles/PMC5409479Test -
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المؤلفون: Richard E. Weaver, Daniel Donnelly, Mark Wigglesworth, Juan Carlos Mobarec, Christopher A. Reynolds
المصدر: Biochemical Pharmacology
مصطلحات موضوعية: 0301 basic medicine, Agonist, Models, Molecular, medicine.drug_class, Stereochemistry, Parathyroid hormone, TIP39, Peptide, Biochemistry, Article, Protein Structure, Secondary, Receptor, Parathyroid Hormone, Type 2, 03 medical and health sciences, Radioligand Assay, GPCR, medicine, Humans, Receptor, G protein-coupled receptor, ComputingMethodologies_COMPUTERGRAPHICS, Receptor, Parathyroid Hormone, Type 1, chemistry.chemical_classification, Pharmacology, 030102 biochemistry & molecular biology, Chemistry, Neuropeptides, Wild type, 3. Good health, Transmembrane domain, 030104 developmental biology, HEK293 Cells, Parathyroid hormone 2 receptor, Mutation, Tyrosine, PTH
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fdd3806e30851e1c571015ebf8d3748Test
http://europepmc.org/articles/PMC5303546Test -
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المؤلفون: Laurence J. Miller, Patrick M. Sexton, John Simms, Kevin J. Smith, Juan Carlos Mobarec, Emilia Elizabeth Savage, Mengjie Liu, Philip E. Thompson, Denise Wootten, Arthur Christopoulos, Rohan Sridhar, Sebastian G.B. Furness, Christopher A. Reynolds, Cassandra Koole, Kavita Pabreja
المصدر: Cell
مصطلحات موضوعية: 0301 basic medicine, Agonist, Models, Molecular, medicine.drug_class, CHO Cells, Biology, Bioinformatics, General Biochemistry, Genetics and Molecular Biology, Article, Glucagon-Like Peptide-1 Receptor, Cell Line, 03 medical and health sciences, Cricetulus, medicine, Functional selectivity, Cyclic AMP, Animals, Humans, Receptor, Glucagon-like peptide 1 receptor, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Effector, Venoms, Biochemistry, Genetics and Molecular Biology(all), Rational design, 3. Good health, Cell biology, Rats, 030104 developmental biology, Oxyntomodulin, Mutagenesis, Site-Directed, Exenatide, Calcium, Signal transduction, Peptides, Intracellular, Signal Transduction
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e74fe2a93af0a34ba07e6605d02f5aTest
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المؤلفون: Valentina Rippa, Ilka B. Bischofs, Patricia Sauer, Juan Carlos Mobarec, Lorenz Adlung, Peter Kolb, Diana Wolf
المصدر: Nucleic Acids Research
مصطلحات موضوعية: Transcriptional Activation, 0301 basic medicine, Molecular Sequence Data, Bacillus subtilis, DNA-binding protein, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Transcription (biology), RNA polymerase, Escherichia coli, Genetics, Direct repeat, Cloning, Molecular, Nucleotide Motifs, Binding site, Promoter Regions, Genetic, Transcription factor, Binding Sites, Base Sequence, biology, Gene regulation, Chromatin and Epigenetics, Inverted Repeat Sequences, Quorum Sensing, DNA-Directed RNA Polymerases, Gene Expression Regulation, Bacterial, biology.organism_classification, Recombinant Proteins, Cell biology, DNA-Binding Proteins, Protein Subunits, Quorum sensing, 030104 developmental biology, chemistry, Protein Multimerization, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11da35645db5cdf06030811266088d5Test
https://doi.org/10.1093/nar/gkv1242Test -
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المؤلفون: Fiona H. Marshall, Juan Carlos Mobarec, Susan H. Brown, James C. Errey, Stephen P. Andrews, Jonathan S. Mason, Malcolm Peter Weir, Kelly N. Steele, Ali Jazayeri, Robert M. Cooke, A. O'Brien, Charlotte Fieldhouse, Iryna Teobald, Alastair J. H. Brown, Brown Giles Albert, Bortolato Andrea, John A. Christopher, Asma H. Baig, Chris de Graaf, Stacey M. Southall, Steve P. Watson, Krzysztof Okrasa, Miles Congreve
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:126611
مصطلحات موضوعية: Drug, endocrine system, media_common.quotation_subject, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Computational biology, 01 natural sciences, Biochemistry, Glucagon-Like Peptide-1 Receptor, Structure-Activity Relationship, Allosteric Regulation, Heterocyclic Compounds, Drug Discovery, Receptors, Glucagon, Amino Acid Sequence, Receptor, Molecular Biology, media_common, Molecular Structure, 010405 organic chemistry, Chemistry, digestive, oral, and skin physiology, Organic Chemistry, Antagonist, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Drug Design, Molecular Medicine, Structure based, Glucagon receptor, Allosteric Site, hormones, hormone substitutes, and hormone antagonists, Protein Binding, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2bdabc56cf80d85af953bc302e66f6Test
https://doi.org/10.1016/j.bmcl.2019.08.015Test -
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المؤلفون: Juan Carlos Mobarec, Christopher A. Reynolds, Michael J. Woolley, John Simms, Alex C. Conner, David R. Poyner
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Biology, Calcitonin gene-related peptide, 01 natural sciences, Biochemistry, Protein Structure, Secondary, Conserved sequence, Cohort Studies, Structure-Activity Relationship, 03 medical and health sciences, Endocrinology, Chlorocebus aethiops, 0103 physical sciences, Cyclic AMP, Animals, Humans, Computer Simulation, Tyrosine, Receptor, Molecular Biology, Conserved Sequence, G protein-coupled receptor, Alanine, chemistry.chemical_classification, 010304 chemical physics, Calcitonin Receptor-Like Protein, Cell Membrane, Tryptophan, Amino acid, 030104 developmental biology, chemistry, Mutagenesis, COS Cells, Mutation, Signal transduction, Receptors, Calcitonin Gene-Related Peptide, Signal Transduction
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609a3b08b96c679c1e0365080ef49dd4Test
https://publications.aston.ac.uk/id/eprint/30885/1/Molecular_functions_of_ECL2_of_CGRP.pdfTest