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المؤلفون: Tuomas Lilius, Hanna Viisanen, Katarzyna Anna Dudek, Fredrik Harry Gustav Ahlström, Jouko Laitila, Eija Kalso, Kert Mätlik, Pekka Rauhala, Kim Juhani Blomqvist
المساهمون: Department of Pharmacology, Faculty of Medicine, University of Helsinki, INDIVIDRUG - Individualized Drug Therapy, Operations Management Unit, Research Programs Unit, HUSLAB, Department of Clinical Pharmacology, Helsinki University Hospital Area, HUS Perioperative, Intensive Care and Pain Medicine, Eija Kalso / Principal Investigator, Department of Diagnostics and Therapeutics, Anestesiologian yksikkö, Pekka Rauhala / Principal Investigator, Medicum
المصدر: Blomqvist, K J, Dudek, K A, Viisanen, H, Matlik, K, Ahlstrom, F H G, Laitila, J, Kalso, E A, Rauhala, P V & Lilius, T O 2022, ' Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats ', Journal of Neuroscience Research, vol. 100, no. 1, pp. 329-338 . https://doi.org/10.1002/jnr.24638Test
Journal of Neuroscience Researchمصطلحات موضوعية: 0301 basic medicine, Male, Narcotic Antagonists, Receptors, Opioid, mu, methylnaltrexone, Pharmacology, Naltrexone, 3124 Neurology and psychiatry, Rats, Sprague-Dawley, 0302 clinical medicine, Drug tolerance, Opioid receptor, ANTINOCICEPTION, PHARMACOLOGY, Morphine, SCR_002798, PAIN, morphine, Drug Tolerance, Methylnaltrexone, NOCICEPTION, 3. Good health, Analgesics, Opioid, Nociception, DOGS, 317 Pharmacy, analgesics, naltrexone, medicine.drug, medicine.drug_class, INHIBITION, METABOLISM, 03 medical and health sciences, Cellular and Molecular Neuroscience, QUATERNARY NARCOTIC-ANTAGONISTS, drug tolerance, medicine, Animals, RRID, Dose-Response Relationship, Drug, business.industry, Antagonist, 3112 Neurosciences, Rats, Quaternary Ammonium Compounds, MICE, 030104 developmental biology, Opioid, Receptors, Opioid, opioid, business, 030217 neurology & neurosurgery, N-METHYLNALTREXONE
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc143dc2a9cc9d9140206a8fec43310Test
https://curis.ku.dk/ws/files/289227935/Antagonism_of_peripheral_opioid.pdfTest -
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المؤلفون: Jouko Laitila, Teijo I. Saari, Kari Laine, Tuija Hemmilä, Mari Fihlman, Klaus T. Olkkola, Nora Hagelberg, Janne T. Backman, Pertti J. Neuvonen
المساهمون: Department of Clinical Pharmacology, Janne Backman / Principal Investigator, Medicum, University of Helsinki, Department of Diagnostics and Therapeutics, Anestesiologian yksikkö, Clinicum, HUS Perioperative, Intensive Care and Pain Medicine, HUSLAB
المصدر: European Journal of Clinical Pharmacology. 74:1615-1622
مصطلحات موضوعية: Male, Antifungal Agents, CYP3A4, HUMAN LIVER-MICROSOMES, Pharmacology, 030226 pharmacology & pharmacy, chemistry.chemical_compound, 0302 clinical medicine, Cytochrome P-450 CYP3A, Medicine, Drug Interactions, Pharmacology (medical), Norbuprenorphine, Biotransformation, SUBLINGUAL BUPRENORPHINE, Cross-Over Studies, OPIOID DEPENDENCE, P-GLYCOPROTEIN, General Medicine, Healthy Volunteers, SYSTEMIC ANTIMYCOTICS, Buprenorphine, 3. Good health, Analgesics, Opioid, IN-VITRO METABOLISM, Transporters, CYTOCHROME-P450 3A4, 317 Pharmacy, Area Under Curve, Female, CLINICAL PHARMACOKINETICS, Half-Life, Drug-drug interaction, medicine.drug, Adult, MAINTENANCE THERAPY, Adolescent, Cmax, Placebo, Dizziness, Sublingual administration, Young Adult, 03 medical and health sciences, Pharmacokinetics, Humans, Voriconazole, business.industry, Drug interaction, N-DEALKYLATION, chemistry, 3111 Biomedicine, business, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e13b2b0d20d49e18e998736b480640cTest
https://doi.org/10.1007/s00228-018-2548-8Test -
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المؤلفون: Fredrik Harry Gustav Ahlström, Hanna Viisanen, Jouko Laitila, Kim Juhani Blomqvist, Tuomas Lilius, Pekka Rauhala, Kert Mätlik, Katarzyna Anna Dudek, Eija Kalso
مصطلحات موضوعية: Opioid, business.industry, Morphine tolerance, medicine, Pharmacology, Receptor, Methylnaltrexone, Antagonism, business, medicine.drug, Peripheral
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c589ffe1ea4313e22c279c8717b29973Test
https://doi.org/10.1002/jnr.24638/v3/response1Test -
4دورية أكاديمية
المؤلفون: Br J Clin Pharmacol, Marika T. Granfors, Janne T. Backman, Jouko Laitila, Pertti J. Neuvonen
المساهمون: The Pennsylvania State University CiteSeerX Archives
مصطلحات موضوعية: elimination
وصف الملف: application/pdf
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المؤلفون: Pertti J. Neuvonen, Klaus T. Olkkola, Nora Hagelberg, Kristiina Kuusniemi, Jouko Laitila, Janne T. Backman, Tuija Hemmilä, Mari Fihlman, Kari Laine, Teijo I. Saari
المساهمون: Medicum, Clinicum, Janne Backman / Principal Investigator, Department of Clinical Pharmacology, Anestesiologian yksikkö, Department of Diagnostics and Therapeutics
المصدر: European Journal of Clinical Pharmacology. 72:1363-1371
مصطلحات موضوعية: Male, ORAL MIDAZOLAM, Posaconazole, Antifungal Agents, Azole antifungals, INTESTINAL-ABSORPTION, HUMAN LIVER-MICROSOMES, Pharmacology, 030226 pharmacology & pharmacy, Intestinal absorption, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Maintenance therapy, Medicine, Drug Interactions, Single-Blind Method, Pharmacology (medical), 030212 general & internal medicine, PHARMACOKINETIC INTERACTION, Cross-Over Studies, P-GLYCOPROTEIN, General Medicine, Sublingual buprenorphine, Healthy Volunteers, Buprenorphine, 3. Good health, Analgesics, Opioid, IN-VITRO METABOLISM, CYTOCHROME-P450 3A4, 317 Pharmacy, Drug-drug interaction, medicine.drug, Adult, MAINTENANCE THERAPY, Administration, Sublingual, Pain, Young Adult, 03 medical and health sciences, Pharmacokinetics, Humans, Voriconazole, CYP3A4, business.industry, Triazoles, SYSTEMIC ANTIMYCOTICS KETOCONAZOLE, 3111 Biomedicine, business, HEALTHY-VOLUNTEERS
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d689112664ed9daf80b666b1d363daeTest
https://doi.org/10.1007/s00228-016-2109-yTest -
6دورية أكاديمية
المؤلفون: Br J Clin Pharmacol, P. J. Neuvonen Md, Tiina Jaakkola, Janne T. Backman, Mikko Neuvonen, Jouko Laitila, Pertti J. Neuvonen
المساهمون: The Pennsylvania State University CiteSeerX Archives
مصطلحات موضوعية: Aims
وصف الملف: application/pdf
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المؤلفون: Tuomas Lilius, Mikko Niemi, Viljami Jokinen, Pekka Rauhala, Eija Kalso, Jouko Laitila
المصدر: European Journal of Pain. 20:297-306
مصطلحات موضوعية: Male, Nociception, Hot Temperature, Gabapentin, Pregabalin, Pain, Pharmacology, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, Animals, Medicine, Drug Interactions, Hot plate test, Pain Measurement, Morphine, business.industry, Rats, 3. Good health, Analgesics, Opioid, Anesthesiology and Pain Medicine, Anesthesia, Neuropathic pain, Drug Therapy, Combination, business, Oxycodone, 030217 neurology & neurosurgery, Tail flick test, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec096076e6fa20fb3a5fff8589906aaTest
https://doi.org/10.1002/ejp.728Test -
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المؤلفون: Janne T. Backman, Klaus T. Olkkola, Mari Fihlman, Teijo I. Saari, Tuija Hemmilä, Jouko Laitila, Pertti J. Neuvonen, Kari Laine, Nora Hagelberg
المساهمون: Medicum, Janne Backman / Principal Investigator, Department of Clinical Pharmacology, Clinicum
المصدر: Pharmacology Research & Perspectives
مصطلحات موضوعية: first‐pass metabolism, education, Analgesic, interaction, Pharmacology, rifampicin, Placebo, 030226 pharmacology & pharmacy, 03 medical and health sciences, First pass effect, chemistry.chemical_compound, 0302 clinical medicine, Medicine, General Pharmacology, Toxicology and Pharmaceutics, Norbuprenorphine, Adverse effect, ta317, sublingual and intravenous buprenorphine, CYP3A4, business.industry, Original Articles, 3. Good health, Neurology, chemistry, 317 Pharmacy, Anesthesia, Original Article, Cytochrome (P450) 3A4, business, 030217 neurology & neurosurgery, Rifampicin, Buprenorphine, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9505ce5075b88e0c9ae89a085a5fc0c8Test
https://doi.org/10.1002/prp2.271Test -
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المؤلفون: Jouko Laitila, Klaus T. Olkkola, Mari Fihlman, Janne T. Backman, Teijo I. Saari, Nora M. Hagelberg, Kari Laine, Tuija Hemmilä, Pertti J. Neuvonen
المساهمون: tyks, vsshp, tyks, vsshp, anestesiologia ja tehohoito, Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, lääket. tdk yhteiset, Lääket. tdk yhteiset, 2607000, 2607301
العلاقة: 74; European Journal of Clinical Pharmacology; 12; https://www.utupub.fi/handle/10024/159490Test; URN:NBN:fi-fe2021042719919
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المؤلفون: Jouko Laitila, Tuomas Lilius, Eija Kalso, Pekka Rauhala, Oleg Kambur, Viljami Jokinen, Mikko Niemi
المصدر: Basicclinical pharmacologytoxicology. 120(1)
مصطلحات موضوعية: Male, medicine.medical_specialty, Pain, Spironolactone, Toxicology, 030226 pharmacology & pharmacy, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Furosemide, Internal medicine, medicine, Animals, Drug Interactions, Tissue Distribution, Hot plate test, Diuretics, Pharmacology, Neurons, Analgesics, Behavior, Animal, Morphine, business.industry, Brain, General Medicine, Chlorothiazide, 3. Good health, Eplerenone, Analgesics, Opioid, Disease Models, Animal, Endocrinology, chemistry, Opioid, Drug Therapy, Combination, business, Oxycodone, 030217 neurology & neurosurgery, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64aff5bc753f8445af444311d7e9c36dTest
https://pubmed.ncbi.nlm.nih.gov/27312359Test
