دورية أكاديمية
Antibiotic susceptibility of Helicobacter pylori in Iceland.
| العنوان: | Antibiotic susceptibility of Helicobacter pylori in Iceland. |
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| المؤلفون: | Gunnarsdottir, Anna Ingibjorg, Gudjonsson, Hallgrimur, Hardardottir, Hjordis, Jonsdottir, Karen Drofn, Bjornsson, Einar Stefan |
| المساهمون: | 1 Natl Univ Hosp Iceland, Landspitali, Hosp Pharm, Reykjavik, Iceland Show the Organization-Enhanced name(s) 2 Univ Iceland, Fac Pharmaceut Sci, Reykjavik, Iceland Show the Organization-Enhanced name(s) 3 Natl Univ Hosp Iceland, Landspitali, Dept Internal Med, Reykjavik, Iceland Show the Organization-Enhanced name(s) 4 Univ Iceland, Fac Med, Reykjavik, Iceland Show the Organization-Enhanced name(s) 5 Natl Univ Hosp Iceland, Landspitali, Dept Clin Microbiol, Reykjavik, Iceland |
| بيانات النشر: | Taylor & Francis |
| سنة النشر: | 2017 |
| المجموعة: | Hirsla - Landspítali University Hospital research archive |
| مصطلحات موضوعية: | Bakteríusjúkdómar, Lyfjameðferð, Magasár, GAS12, LYF12, BAC12, Helicobacter pylori, Drug Resistance, Bacterial |
| الوصف: | To access publisher's full text version of this article click on the hyperlink below ; Increasing resistance of Helicobacter pylori (H. pylori) to antibiotics calls for constant re-evaluation of multidrug regimens that have been used to eradicate the infection. The aim of this study was to evaluate the current antibiotic susceptibility of H. pylori in an Icelandic cohort. ; Patients referred for gastroscopy were recruited prospectively. Those found to have a positive rapid urease test were included in the study. Susceptibility testing was conducted by the Epsilometer test (E-test) method for ampicillin, clarithromycin, levofloxacin, metronidazole and tetracycline. Results were obtained after three days of incubation in microaerophilic conditions at 37 °C, except for the metronidazole were the first 24 hours were anaerobic. ; Of the 613 patients who underwent gastroscopy, 138 (23%) had a positive rapid urease test. H. pylori was successfully cultured from 105 (76%) of the urease test positive patients and the isolates were tested for antibiotic susceptibility. Five patients had prior H. pylori eradication. Antibiotic resistance for ampicillin, clarithromycin, levofloxacin, metronidazole and tetracycline was 0%, 9%, 4%, 1% and 0%, respectively. If those who had previously undergone eradication treatment were excluded, the resistance was 0%, 6%, 3%, 1% and 0%, respectively. Clarithromycin resistance was higher amongst women than men, 13% vs. 5%, however, not significantly. Clarithromycin resistance was 60% amongst those who had previously received eradication treatment compared to 6% of those who had not (p < .0001). ; Clarithromycin resistance amongst the H. pylori isolates can be considered relatively low. Therefore, in the current cohort, standard triple-drug clarithromycin-containing regimen should remain the first-line treatment against H. pylori. ; Actavis Group ptc Landspitali University Hospital of Iceland |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2374-4243 28440099 |
| العلاقة: | Antibiotic susceptibility of Helicobacter pylori in Iceland. 2017, 49 (9):647-654 Infect Dis (Lond); http://hdl.handle.net/2336/620275Test; Infectious diseases (London, England) |
| DOI: | 10.1080/23744235.2017.1317359 |
| الإتاحة: | https://doi.org/10.1080/23744235.2017.1317359Test http://hdl.handle.net/2336/620275Test |
| حقوق: | Archived with thanks to Infectious diseases (London, England) ; Landspitali Access - LSH-aðgangur |
| رقم الانضمام: | edsbas.1D400F78 |
| قاعدة البيانات: | BASE |
| تدمد: | 23744243 28440099 |
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| DOI: | 10.1080/23744235.2017.1317359 |