المؤلفون: Giuseppe Campiani (1714282), Caterina Cavella (7852640), Jeremy D. Osko (5262062), Margherita Brindisi (1714312), Nicola Relitti (5143451), Simone Brogi (715714), A. Prasanth Saraswati (9460123), Stefano Federico (9460126), Giulia Chemi (4887832), Samuele Maramai (1871650), Gabriele Carullo (6384479), Benedikt Jaeger (11113215), Alfonso Carleo (11113218), Rosaria Benedetti (1859671), Federica Sarno (3232011), Stefania Lamponi (140398), Paola Rottoli (8467725), Elena Bargagli (8467728), Carlo Bertucci (1703254), Daniele Tedesco (1703248), Daniel Herp (3930101), Johanna Senger (1463518), Giovina Ruberti (687850), Fulvio Saccoccia (2400835), Simona Saponara (1714297), Beatrice Gorelli (1714279), Massimo Valoti (1960363), Breándan Kennedy (11113221), Husvinee Sundaramurthi (9302249), Stefania Butini (1714288), Manfred Jung (26925), Katy M. Roach (7630040), Lucia Altucci (96038), Peter Bradding (60398), David W. Christianson (1294293), Sandra Gemma (1714309), Antje Prasse (354621)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, HDAC 6, IPF lung tissues, lung model, HDAC 6 overexpression, Biological Evaluation, first-in-class molecules, HDAC activities, vivo toxicity, Structural analysis, fibrotic sphere formation, novel h HDAC 6 inhibitors, binding mode, immunohistochemistry studies, Idiopathic Pulmonary Fibrosis, IPF phenotype, analogue 6 h, Potent Inhibitors Idiopathic, lung disease, h HDAC 1, TGF -β1-dependent fibrogenesis, cell viability

العلاقة: https://figshare.com/articles/journal_contribution/Harnessing_the_Role_of_HDAC6_in_Idiopathic_Pulmonary_Fibrosis_Design_Synthesis_Structural_Analysis_and_Biological_Evaluation_of_Potent_Inhibitors/14959785Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00184.s001Test

المؤلفون: Bertrand Lecointre, Remy Narozny, Maria Teresa Borrello, Johanna Senger, Alokta Chakrabarti, Manfred Jung, Martin Marek, Christophe Romier, Jelena Melesina, Wolfgang Sippl, Laurent Bischoff, A. Ganesan

مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Health Care, Diseases, Epidemiology, zinc metalloenzymes, epigenetics, histone deacetylases, enzyme inhibitors, peptidomimetics

العلاقة: https://figshare.com/articles/journal_contribution/Supporting_Information_from_Isoform-selective_HDAC1_6_8_inhibitors_with_an_imidazo-ketopiperazine_cap_containing_stereochemical_diversity/6024872Test

الإتاحة: https://doi.org/10.6084/m9.figshare.6024872.v1Test
https://figshare.com/articles/journal_contribution/Supporting_Information_from_Isoform-selective_HDAC1_6_8_inhibitors_with_an_imidazo-ketopiperazine_cap_containing_stereochemical_diversity/6024872Test

المؤلفون: Fulvio, Saccoccia, Margherita, Brindisi, Roberto, Gimmelli, Nicola, Relitti, Alessandra, Guidi, A Prasanth, Saraswati, Caterina, Cavella, Simone, Brogi, Giulia, Chemi, Stefania, Butini, Giuliana, Papoff, Johanna, Senger, Daniel, Herp, Manfred, Jung, Giuseppe, Campiani, Sandra, Gemma, Giovina, Ruberti

المصدر: ACS infectious diseases. 6(1)

مصطلحات موضوعية: Anthelmintics, Histone Deacetylase Inhibitors, Male, Molecular Docking Simulation, Mice, Structure-Activity Relationship, Phenotype, Drug Discovery, Animals, Female, Schistosoma mansoni, Crystallography, X-Ray, High-Throughput Screening Assays

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::59fb301b3dfefca8f7b2da1cd0334c52Test
https://pubmed.ncbi.nlm.nih.gov/31661956Test

المؤلفون: Jelena Melesina, Johanna Senger, Olaf Witt, Ina Oehme, Wolfgang Sippl, Alokta Chakrabarti, Manfred Jung, Fiona R. Kolbinger

المصدر: Future Medicinal Chemistry. 8:1609-1634

مصطلحات موضوعية: 0301 basic medicine, Druggability, Antineoplastic Agents, Biology, Histone Deacetylases, 03 medical and health sciences, 0302 clinical medicine, Non-histone protein, Neoplasms, Drug Discovery, medicine, Humans, Transcription factor, Pharmacology, chemistry.chemical_classification, Histone deacetylase 5, Cancer, Neurodegenerative Diseases, HDAC8, medicine.disease, Repressor Proteins, Neuroprotective Agents, 030104 developmental biology, Enzyme, Histone, chemistry, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39d41c1f4d10ff06f3ad891cdbb8133Test
https://doi.org/10.4155/fmc-2016-0117Test

المؤلفون: Francesca Massenzio, Sabrina Petralla, Andressa Souza de Oliveira, Jéssica Larissa da Costa Nunes, Giulio Vistoli, Tereza Kobrlova, Annachiara Gandini, Ondrej Soukup, Camila de Oliveira Miranda, Barbara Monti, Gabriella Simões Heyn Roth Cardoso, Luiz Antonio Soares Romeiro, Maria Laura Bolognesi, Manfred Jung, Michele Rossi, Silvia Gervasoni, Johanna Senger

المساهمون: Romeiro L.A.S., Da Costa Nunes J.L., De Oliveira Miranda C., Simoies Heyn Roth Cardoso G., De Oliveira A.S., Gandini A., Kobrlova T., Soukup O., Rossi Michele., Senger J., Jung M., Gervasoni S., Vistoli G., Petralla S., Massenzio F., Monti B., Bolognesi M.L.

المصدر: ACS medicinal chemistry letters. 10(4)

مصطلحات موضوعية: Drug, media_common.quotation_subject, Global problem, Waste material, Disease, Pharmacology, immunomodulation, 01 natural sciences, Biochemistry, Drug Discovery, medicine, HDAC inhibitor, Dementia, Cashew nut, Vorinostat, media_common, 010405 organic chemistry, business.industry, Neurodegenerative drug discovery, Organic Chemistry, sustainable drugs, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, food waste, business, medicine.drug

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c9d0630daf9f208282e3a29aaf4252Test
https://pubmed.ncbi.nlm.nih.gov/30996816Test

المؤلفون: Nicholas J. Porter, Daniel Herp, Wolfgang Sippl, Martin Müller, Karin Bartel, Franz Bracher, Nghia Ong, Johanna Senger, Christophe Romier, Dina Robaa, Katharina Vögerl, Tajith B. Shaik, Karin Schmidtkunz, Manfred Jung, David W. Christianson, Martin Marek

المساهمون: Albert-Ludwigs-Universität Freiburg, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Programming Systems Lab [Saarland], Saarland University [Saarbrücken], Martin-Luther-Universität Halle Wittenberg (MLU), Department of Chemistry, University of Pennsylvania [Philadelphia], Institute of Pharmaceutical Chemistry, Ludwig-Maximilians University [Munich] (LMU)

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (3), pp.1138-1166. ⟨10.1021/acs.jmedchem.8b01090⟩

مصطلحات موضوعية: 0303 health sciences, HDAC8, HDAC6, 01 natural sciences, HDAC4, HDAC1, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, Biochemistry, chemistry, Acetylation, Docking (molecular), Phenothiazine, Drug Discovery, Molecular Medicine, Structure–activity relationship, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], ComputingMilieux_MISCELLANEOUS, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a372f6728b12afc0c3e3b70e562ea7Test
https://hal.archives-ouvertes.fr/hal-02391127Test

المؤلفون: Simone Brogi, Dora Mariagrazia Cucinella, Daniel Herp, Giuseppe Campiani, Ettore Novellino, Johanna Senger, Concetta Iside, Angela Nebbioso, Lucia Altucci, Christophe Romier, Giulia Chemi, Alessandro Grillo, Stefania Butini, Stefania Lamponi, Margherita Brindisi, Sandra Gemma, Tajith B. Shaik, Federica Sarno, Caterina Cavella, Manfred Jung

المساهمون: Dipartimento di Biologia e Patologia Cellulare e Moleculare, Università degli studi di Napoli Federico II, Department of Pharmacy Naples, Université de Naples, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), European Research Centre for Drug Discovery and Development, Banchi di Sotto 55 and Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena = University of Siena (UNISI), Dip. Patologia generale, Seconda Università di Napoli, Brindisi, Margherita, Senger, Johanna, Cavella, Caterina, Grillo, Alessandro, Chemi, Giulia, Gemma, Sandra, Cucinella, Dora Mariagrazia, Lamponi, Stefania, Sarno, Federica, Iside, Concetta, Nebbioso, Angela, Novellino, Ettore, Shaik, Tajith Baba, Romier, Christophe, Herp, Daniel, Jung, Manfred, Butini, Stefania, Campiani, Giuseppe, Altucci, Lucia, Brogi, Simone

المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 157, pp.127-138. ⟨10.1016/j.ejmech.2018.07.069⟩

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Cell, Apoptosis, Histone Deacetylase 1, Drug Screening Assays, Histone Deacetylase 6, 0302 clinical medicine, Models, Cell Movement, HDAC, Drug Discovery, ComputingMilieux_MISCELLANEOUS, Tumor, Molecular Structure, Chemistry, Cell Cycle, Epigenetic, Enzyme inhibitors, Cell migration, Antitumor agents, Bioinformatics, Drug design, Epigenetics, Antineoplastic Agents, Cell Line, Tumor, Cell Proliferation, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Histone Deacetylase Inhibitors, Humans, Structure-Activity Relationship, General Medicine, Enzyme inhibitor, 3. Good health, medicine.anatomical_structure, Biochemistry, 030220 oncology & carcinogenesis, Drug, Cell Line, Dose-Response Relationship, 03 medical and health sciences, Histone H3, medicine, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Bioinformatic, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Antitumor agent, Molecular, Antitumor, HDAC6, HDAC1, 030104 developmental biology, Acetylation, Cancer cell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75382057bda49ca5776292feb2ca5c3dTest
https://hal.archives-ouvertes.fr/hal-02391151Test

المؤلفون: Wolfgang Sippl, Olaf Witt, Christophe Romier, Ina Oehme, Johanna Senger, Martin Marek, Jelena Melesina, Manfred Jung

المصدر: Journal of Medicinal Chemistry. 59:1545-1555

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Lysine, Histone Deacetylase 6, Hydroxamic Acids, Histone Deacetylases, Histones, 03 medical and health sciences, chemistry.chemical_compound, Tubulin, Drug Discovery, Humans, Thiazole, Oxazoles, Oxazole, biology, Acetylation, HDAC8, HDAC6, Histone Deacetylase Inhibitors, Molecular Docking Simulation, 030104 developmental biology, Histone, chemistry, Biochemistry, Docking (molecular), biology.protein, Molecular Medicine, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d159b1529e1b09d842a561218af61281Test
https://doi.org/10.1021/acs.jmedchem.5b01493Test

المؤلفون: Wolfgang Sippl, Johanna Senger, Jelena Melesina, Maria Teresa Borrello, Alokta Chakrabarti, Arasu Ganesan, Christophe Romier, Bertrand Lecointre, Laurent Bischoff, Remy Narozny, Martin Marek, Manfred Jung

المساهمون: Chimie Organique et Bioorganique : Réactivité et Analyse (COBRA), Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie Organique Fine (IRCOF), Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Albert-Ludwigs-Universität Freiburg, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Martin-Luther-Universität Halle Wittenberg (MLU), Institute of Pharmaceutical Chemistry

المصدر: Philosophical Transactions of the Royal Society B: Biological Sciences
Philosophical Transactions of the Royal Society B: Biological Sciences, Royal Society, The, 2018, 373 (1748), pp.20170364. ⟨10.1098/rstb.2017.0364⟩

مصطلحات موضوعية: Gene isoform, Stereochemistry, Peptidomimetic, THP-1 Cells, Stereoisomerism, Histone Deacetylase 1, 010402 general chemistry, Histone Deacetylase 6, Hydroxamic Acids, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, Histone Deacetylases, Structure-Activity Relationship, Structure–activity relationship, Humans, Protein Isoforms, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], 010405 organic chemistry, Chemistry, Acetylation, U937 Cells, Articles, HDAC1, 0104 chemical sciences, 3. Good health, Histone Deacetylase Inhibitors, Molecular Docking Simulation, Repressor Proteins, General Agricultural and Biological Sciences, Linker

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f8edf3658a937d06c7df9be4c8a538Test
https://pubmed.ncbi.nlm.nih.gov/29685969Test

المؤلفون: Lucas Praetorius, Manfred Jung, Stefanie Goskowitz, Johanna Senger, Carmela Michalek, Michaela Klaß, Philipp Borchert, Wolfgang Sippl, Norbert Sewald, Karin Schmidtkunz, Sabrina Schwarzbich, Matthias Wünsch, Philipp Schultheisz

المصدر: ChemMedChem. 12(24)

مصطلحات موضوعية: 0301 basic medicine, propargylamine, Stereochemistry, Antineoplastic Agents, Histone Deacetylase 6, Biochemistry, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Cell Line, Tumor, inhibitors, Drug Discovery, cancer, Structure–activity relationship, Humans, General Pharmacology, Toxicology and Pharmaceutics, Cytotoxicity, Cell Proliferation, Pharmacology, heterocycles, biology, Dose-Response Relationship, Drug, Molecular Structure, Propylamines, Chemistry, Organic Chemistry, HDAC8, HDAC6, HDAC1, Histone Deacetylase Inhibitors, 030104 developmental biology, Histone, Pargyline, Docking (molecular), 030220 oncology & carcinogenesis, histone deacetylase, biology.protein, Molecular Medicine, Histone deacetylase, Drug Screening Assays, Antitumor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa5c7973ca7287ec81a05de6136d1c4Test
https://pubmed.ncbi.nlm.nih.gov/29120081Test