يعرض 1 - 10 نتائج من 16 نتيجة بحث عن '"Joanna M. Watt"', وقت الاستعلام: 1.03s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors

    المؤلفون: Xiangdong Su, Wolfgang Dohle, Stephen J. Mills, Joanna M. Watt, Ana M. Rossi, Colin W. Taylor, Barry V. L. Potter

    المصدر: ACS Omega, Vol 5, Iss 44, Pp 28793-28811 (2020)

    مصطلحات موضوعية: Chemistry, QD1-999

    وصف الملف: electronic resource

    العلاقة: https://doaj.org/toc/2470-1343Test

    الوصول الحر: https://doaj.org/article/d94ccb6b6c4f468785da8db2c6a81162Test

    View record in DOAJ النص الكامل

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  2. 2
    دورية أكاديمية
    Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship

    المؤلفون: Joanna M. Watt, Richard Graeff, Barry V. L. Potter

    المصدر: Molecules, Vol 26, Iss 23, p 7165 (2021)

    مصطلحات موضوعية: synthesis, cADPR, cyclase, nucleotide, fragment, Organic chemistry, QD241-441

    وصف الملف: electronic resource

    العلاقة: https://www.mdpi.com/1420-3049/26/23/7165Test; https://doaj.org/toc/1420-3049Test

    الوصول الحر: https://doaj.org/article/a4b277117732405ca369cdbf4afde384Test

    View record in DOAJ النص الكامل

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  3. 3
    Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors

    المؤلفون: Colin W. Taylor, Barry V. L. Potter, Stephen J Mills, Xiangdong Su, Ana M. Rossi, Wolfgang Dohle, Joanna M. Watt

    المصدر: ACS Omega, Vol 5, Iss 44, Pp 28793-28811 (2020)

    مصطلحات موضوعية: Agonist, 010405 organic chemistry, medicine.drug_class, Stereochemistry, General Chemical Engineering, Diastereomer, Convergent synthesis, General Chemistry, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, Chemistry, Adenophostin, chemistry, medicine, Inositol, Chirality (chemistry), QD1-999, Amination, Conjugate

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41599b32dc386f30400b670167e80a8cTest
    https://doaj.org/article/d94ccb6b6c4f468785da8db2c6a81162Test


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  4. 4
    Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship

    المؤلفون: Richard M. Graeff, Joanna M. Watt, Barry V. L. Potter

    المصدر: Molecules; Volume 26; Issue 23; Pages: 7165
    Watt, J M, Graeff, R & Potter, B V L 2021, ' Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-Inosine 5'-Monophosphate, Analogues and Early Structure-Activity Relationship ', Molecules, vol. 26, no. 23, 7165 . https://doi.org/10.3390/molecules26237165Test
    Molecules, Vol 26, Iss 7165, p 7165 (2021)

    مصطلحات موضوعية: synthesis, Stereochemistry, Pharmaceutical Science, Organic chemistry, 010402 general chemistry, 01 natural sciences, Cyclase, fragment, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, QD241-441, Drug Discovery, medicine, Structure–activity relationship, Physical and Theoretical Chemistry, Inosine, 030304 developmental biology, cADPR, cyclase, nucleotide, 0303 health sciences, Total synthesis, Ligand (biochemistry), Adenosine, Small molecule, 0104 chemical sciences, chemistry, Chemistry (miscellaneous), Molecular Medicine, Bioisostere, medicine.drug

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a73339c8c5d1340c4e586553c81a16eTest


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  5. 5
    Synthesis of phosphonoacetate analogues of the second messenger adenosine 5′-diphosphate ribose (ADPR)

    المؤلفون: Ondřej Baszczyňski, Ralf Fliegert, Joanna M. Watt, Andreas H. Guse, Barry V. L. Potter, Monika D. Rozewitz

    مصطلحات موضوعية: 0303 health sciences, 010405 organic chemistry, General Chemical Engineering, Biological activity, General Chemistry, Nicotinamide adenine dinucleotide, 01 natural sciences, Pyrophosphate, Adenosine, Article, 0104 chemical sciences, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Biochemistry, Ribose, medicine, TRPM2, NAD+ kinase, Pyrophosphatases, 030304 developmental biology, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdee1cee47ef5ef7d2feab98beefe07Test
    https://europepmc.org/articles/PMC6957348Test/


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  6. 6
    Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349

    المؤلفون: Wiebke Sick, Angelika Harneit, Andrea C. Araujo, Ralf Fliegert, Monika D. Rozewitz, Anja Schöbel, Tanja Kirchberger, Joanna M. Watt, Mark P. Thomas, Andreas H. Guse, Barry V. L. Potter, Christelle Moreau

    المصدر: Biochemical Journal

    مصطلحات موضوعية: 0301 basic medicine, Patch-Clamp Techniques, Protein Conformation, Chemical biology, TRPM Cation Channels, Arginine, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Protein structure, transient receptor potential channels, Ribose, medicine, Humans, TRPM2, Amino Acid Sequence, Calcium Signaling, protein structure, Pyrophosphatases, Molecular Biology, Research Articles, chemistry.chemical_classification, Adenosine Diphosphate Ribose, Sequence Homology, Amino Acid, 030102 biochemistry & molecular biology, Chemistry, Adenosine diphosphate ribose, Rational design, Cell Biology, Adenosine, Amino acid, HEK293 Cells, 030104 developmental biology, Mutation, Mutagenesis, Site-Directed, Biophysics, Tyrosine, Calcium, Ion Channel Gating, Research Article, Protein Binding, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e149b107746fd09de4ed57b19cf45fbbTest
    https://doi.org/10.1042/bcj20170091Test


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  7. 7
    Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2

    المؤلفون: Joanna M. Watt, Ondřej Baszczyňski, Barry V. L. Potter, Ralf Fliegert, Andreas H. Guse, Monika D. Rozewitz

    المصدر: Potter, B, Watt, J M & Baszczynski, O 2019, ' Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2 ', Journal of Organic Chemistry, vol. 84, no. 10, pp. 6143-6157 . https://doi.org/10.1021/acs.joc.9b00338Test

    مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, TRPM Cation Channels, Chemistry Techniques, Synthetic, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, Transient receptor potential channel, Protein structure, Ribose, medicine, Humans, TRPM2, Nucleotide, chemistry.chemical_classification, Adenosine Diphosphate Ribose, 010405 organic chemistry, Organic Chemistry, Rational design, Adenosine, 0104 chemical sciences, HEK293 Cells, chemistry, Molecular Probes, Nucleoside, medicine.drug

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad5f862548e37f7f65ab31154afeb57Test
    https://purehost.bath.ac.uk/ws/files/190639500/SI_Terminal_ribose_JOC_revised_F.pdfTest


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  8. 8
    Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR

    المؤلفون: Frank J. P. Kühn, Andreas Lückhoff, Barry V. L. Potter, Joanna M. Watt

    المصدر: Scientific Reports
    Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)

    مصطلحات موضوعية: 0301 basic medicine, Substrate Specificities, food.ingredient, Ribose, Mutant, lcsh:Medicine, TRPM Cation Channels, Nematostella, Gating, Article, Substrate Specificity, 03 medical and health sciences, Transient receptor potential channel, 0302 clinical medicine, food, Animals, Humans, TRPM2, Binding site, lcsh:Science, Adenosine Diphosphate Ribose, Multidisciplinary, Binding Sites, Chemistry, lcsh:R, Cell biology, Kinetics, 030104 developmental biology, HEK293 Cells, Sea Anemones, lcsh:Q, Inosine Diphosphate, Ion Channel Gating, 030217 neurology & neurosurgery, Function (biology)

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3cdec66ae6c4b5b59275bd9092aa83cTest
    http://ora.ox.ac.uk/objects/uuidTest:


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  9. 9
    Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers

    المؤلفون: Joanna M, Watt, Mark P, Thomas, Barry V L, Potter

    المصدر: Scientific Reports

    مصطلحات موضوعية: Models, Molecular, Cyclic ADP-Ribose, Aplysia, Molecular Conformation, Animals, Stereoisomerism, ADP-ribosyl Cyclase, Crystallography, X-Ray, Second Messenger Systems, Article

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::e6a0d61f0d06ed1bd4c6c8cd86839a1eTest
    https://pubmed.ncbi.nlm.nih.gov/30323284Test


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  10. 10
    Context-dependent calcium signaling in encephalitogenic T cells – an in vivo two-photon imaging study

    المؤلفون: Stephanie Everts, Nikolaos I. Kyratsous, Ingo Bartholomäus, Guokun Zhang, Marija Pesic, Joanna M. Watt, Naoto Kawakami, Miriam Wörner, Ping Fang, Reinhard Hohlfeld, H. Wekerle, Marsilius Mues, Joachim W. Ellwart, Isabel J. Bauer, Barry V. L. Potter

    المصدر: Proceedings of the National Academy of Sciences of the United States of America
    Proc. Natl. Acad. Sci. U.S.A. 114, E6381-E6389 (2017)

    مصطلحات موضوعية: 0301 basic medicine, Stromal cell, Encephalomyelitis, Autoimmune, Experimental, T-Lymphocytes, Antigen-Presenting Cells, Spleen, Autoimmunity, Biology, Lymphocyte Activation, Autoantigens, Calcium in biology, Cell Line, 03 medical and health sciences, T-cell Activation, Central Nervous System, Intracellular Calcium, Two-photon Imaging, medicine, Cytotoxic T cell, Animals, Calcium Signaling, Antigen-presenting cell, Calcium signaling, Multidisciplinary, NFATC Transcription Factors, Experimental autoimmune encephalomyelitis, Transendothelial and Transepithelial Migration, Brain, NFAT, medicine.disease, Cell biology, Rats, 030104 developmental biology, medicine.anatomical_structure, Microscopy, Fluorescence, Multiphoton, PNAS Plus, Blood-Brain Barrier, Rats, Inbred Lew, Immunology, Female

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b476f2bc673a22acb3cea6e6db102bTest
    http://ora.ox.ac.uk/objects/uuidTest:


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