التفاصيل البيبلوغرافية
| العنوان: |
Body weight changes after adjuvant chemotherapy of patients with breast cancer: results of a Mexican cohort study. |
| المؤلفون: |
Vargas‐Meza, A., Chavez‐Tostado, M., Cortes‐Flores, A.O., Urias‐Valdez, D., Delgado‐Gomez, M., Morgan‐Villela, G., Zuloaga‐Fernandez Del Valle, C., Jimenez‐Tornero, J., Zuloaga‐Fernandez Del Valle, R., Fuentes‐Orozco, C., García‐Rentería, J., Rendón‐Félix, J., Cuesta‐Márquez, L., Gonzalez‐Ojeda, A. |
| المصدر: |
European Journal of Cancer Care; Sep2017, Vol. 26 Issue 5, pn/a-N.PAG, 7p, 3 Charts |
| مصطلحات موضوعية: |
ANTHROPOMETRY, BODY weight, BREAST tumors, CHI-squared test, COMBINED modality therapy, CONFIDENCE intervals, INGESTION, LONGITUDINAL method, MULTIVARIATE analysis, T-test (Statistics), WEIGHT loss, PERIMENOPAUSE, RETROSPECTIVE studies, POSTMENOPAUSE, DATA analysis software, INFERENTIAL statistics, ODDS ratio |
| مصطلحات جغرافية: |
MEXICO |
| مستخلص: |
Weight gain is observed in breast cancer patients receiving chemotherapy and is a well-known complication. Several factors that contributing to weight gain have been identified. However, there is a lack of information about factors associated with weight changes following adjuvant chemotherapy. A retrospective cohort of 200 pre- and post-menopausal Mexican patients treated for breast cancer was made. Anthropometric variables were measured before/after treatment. Biomarkers, cellular differentiation and chemotherapy were similar between groups. Weight gain occurred in 85.6% of pre-menopausal and 72.6% of post-menopausal women ( p = .03). At the end of chemotherapy, weight and body mass index ( BMI) did not differ significantly between pre-menopausal (69.3 ± 12.6 kg; 26.6 ± 4.8 kg/m2) and post-menopausal women (69.5 ± 10.9 kg; 27.3 ± 4.4 kg/m2) ( p = .91 and 0.34). Dexamethasone doses were higher in pre-menopausal (85.7 ± 39.1 g) than post-menopausal patients (79.2 ± 22.5 g; p = .13). Weight loss was observed in 9.2% of pre-menopausal and 20.2% of post-menopausal patients ( p = .04). A multivariate analysis revealed that age ( OR = 2.7; 95% CI = 1.26-5.79; p = .01), menopausal status ( OR = 2.29; 95% CI = 1.09-4.80; p = .03), dexamethasone dosage ( OR = 2.1; 95% CI = 1.04-4.23; p = .03) and daily caloric intake ( OR = 2.3; 95% CI = 1.12-5.10; p = .02) were independent variables that inducted weight gain. Pre- and post-menopausal women gained weight, but more pre-menopausal patients showed gain. An effort should be made to administer lower steroid doses to reduce weight gain. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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