The Effect on Sodium/Iodide Symporter and Pendrin in Thyroid Colloid Retention Developed by Excess Iodide Intake
| العنوان: | The Effect on Sodium/Iodide Symporter and Pendrin in Thyroid Colloid Retention Developed by Excess Iodide Intake |
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| المؤلفون: | Jin-Wei Zhang, Xiao-Yi Chen, Chu-Hui Lin, Wen-Wei Zheng, Wang-Gen Li, Wang Xiang, Yi-Xiong Lei, Jia-Luan Huang, Jiang Qian, Li-Hua Yang |
| المصدر: | Biological Trace Element Research. 172:193-200 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | 0301 basic medicine, Sodium-iodide symporter, endocrine system, medicine.medical_specialty, Goiter, Endocrinology, Diabetes and Metabolism, Anion Transport Proteins, Clinical Biochemistry, Iodide, Thyroid Gland, chemistry.chemical_element, Iodine, Biochemistry, Inorganic Chemistry, Mice, 03 medical and health sciences, Internal medicine, medicine, Animals, Colloids, chemistry.chemical_classification, Mice, Inbred BALB C, Symporters, biology, Chemistry, Biochemistry (medical), Thyroid, General Medicine, Pendrin, Iodides, medicine.disease, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Sulfate Transporters, Symporter, biology.protein, Female, Thyroid function |
| الوصف: | It is well known that excess iodide can lead to thyroid colloid retention, a classic characteristic of iodide-induced goiter. However, the mechanism has not been fully unrevealed. Iodide plays an important role in thyroid function at multiple steps of thyroid colloid synthesis and transport among which sodium/iodide symporter (NIS) and pendrin are essential. In our study, we fed female BALB/c mice with different concentrations of high-iodine water including group A (control group, 0 μg/L), group B (1500 μg/L), group C (3000 μg/L), group D (6000 μg/L), and group E (12,000 μg/L). After 7 months of feeding, we found that excess iodide could lead to different degrees of thyroid colloid retention. Besides, NIS and pendrin expression were downregulated in the highest dose group. The thyroid iodide intake function detected by urine iodine assay and thyroidal (125)I experiments showed that the urine level of iodine increased, while the iodine intake rate decreased when the concentration of iodide used in feeding water increased (all p |
| تدمد: | 1559-0720 0163-4984 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d466971378a28a5b2c65880044f9e2Test https://doi.org/10.1007/s12011-015-0580-4Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f0d466971378a28a5b2c65880044f9e2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590720 01634984 |
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