دورية أكاديمية
Impact of muscle mass on survival of patients with hepatocellular carcinoma after liver transplantation beyond the Milan criteria
| العنوان: | Impact of muscle mass on survival of patients with hepatocellular carcinoma after liver transplantation beyond the Milan criteria |
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| المؤلفون: | Berend R. Beumer, Jeroen L.A. vanVugt, Gonzalo Sapisochin, Peter Yoon, Marco Bongini, Di Lu, Xiao Xu, Paolo De Simone, Lorenzo Pintore, Nicolas Golse, Malgorzata Nowosad, William Bennet, Emmanouil Tsochatzis, Evangelia Koutli, Fariba Abbassi, Marco P.A.W. Claasen, Manuela Merli, Joanne O'Rourke, Martina Gambato, Alberto Benito, Avik Majumdar, Ek Khoon Tan, Maryam Ebadi, Aldo J. Montano‐Loza, Marina Berenguer, Herold J. Metselaar, Wojciech G. Polak, Vincenzo Mazzaferro, Jan N.M. IJzermans, Collaborators |
| المصدر: | Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 5, Pp 2373-2382 (2022) |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the musculoskeletal system LCC:Human anatomy |
| مصطلحات موضوعية: | Hepatocellular carcinoma, Liver transplantation, Skeletal muscle mass, Sarcopenia, Survival, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695 |
| الوصف: | Abstract Background Access to the liver transplant waitlist for patients with hepatocellular carcinoma (HCC) depends on tumour presentation, biology, and response to treatments. The Milan Criteria (MC) represent the benchmark for expanded criteria that incorporate additional prognostic factors. The purpose of this study was to determine the added value of skeletal muscle index (SMI) in HCC patients beyond the MC. Method Patients with HCC that were transplanted beyond the MC were included in this retrospective multicentre study. SMI was quantified using the Computed Tomography (CT) within 3 months prior to transplantation. Cox regression models were used to identify predictors of overall survival (OS). The discriminative performance of SMI extended Metroticket 2.0 and AFP models was also assessed. Results Out of 889 patients transplanted outside the MC, 528 had a CT scan within 3 months prior to liver transplantation (LT), of whom 176 (33%) were classified as sarcopenic. The median time between assessment of the SMI and LT was 1.8 months (IQR: 0.77–2.67). The median follow‐up period was 5.1 95% CI [4.7–5.5] years, with a total of 177 recorded deaths from any cause. In a linear regression model with SMI as the dependent variable, only male gender (8.55 95% CI [6.51–10.59], P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2190-6009 2190-5991 |
| العلاقة: | https://doaj.org/toc/2190-5991Test; https://doaj.org/toc/2190-6009Test |
| DOI: | 10.1002/jcsm.13053 |
| الوصول الحر: | https://doaj.org/article/09a5ef2067314d928baf0c5a0b245f29Test |
| رقم الانضمام: | edsdoj.09a5ef2067314d928baf0c5a0b245f29 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21906009 21905991 |
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| DOI: | 10.1002/jcsm.13053 |