التفاصيل البيبلوغرافية
| العنوان: |
Immune-Enhancing Activity of Vitis coignetiae Extract via Increasing Cytokine and Natural Killer Cell Activity in Splenocytes and Cyclophosphamide-Induced Immunosuppressed Rats. |
| المؤلفون: |
Park, Young Mi, Lee, Hak Yong, Shin, Dong Yeop, Jeong, Han Na, Hwang, Hai Min, Park, Hyo Yeon, Kim, Suk Hun, Kim, Min Ji, Kang, Hee Joo, Kim, Jin Hee, Kim, Myung-sunny, Yang, Hye Jeong, Kim, Min Jung, Kim, Jae Gon |
| المصدر: |
Journal of Food Biochemistry; 5/6/2024, Vol. 2024, p1-12, 12p |
| مصطلحات موضوعية: |
GRAPES, TUMOR necrosis factors, LABORATORY rats, KILLER cells, RATS, CYTOKINES, IMMUNOGLOBULIN M, KILLER cell receptors |
| مستخلص: |
Plant and fruit extracts exhibit fewer side effects than pharmaceuticals and can display therapeutic qualities. Consequently, they have attracted increased attention among health-conscious individuals, and many studies related to their health-promoting effects are being actively conducted. Vitis coignetiae is well-known for its antioxidant, anti-inflammatory, and anticancer properties. However, the immune-enhancing effects of Vitis coignetiae have not yet been studied. In this study, Vitis coignetiae extract (VCE) increased immune-related activity in Wistar rat splenocytes and cyclophosphamide (Cy)-induced immunosuppressed rats. In splenocytes, VCE was nontoxic up to 300 μg/mL and increased cell viability in the presence of Cy. VCE also recovered Cy-induced decreases in cytokine (tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interleukin-2 (IL-2), and IL-12) levels and natural killer (NK) cell activity in splenocytes. In Cy-induced immunosuppressed rats, VCE protected against Cy-induced spleen tissue damage and decreases in body and spleen weight, cytokine (TNF-α, IFN-γ, IL-2, and IL-12) levels, and NK cell activity. We also observed recovery of immunoglobulin G (IgG) and IgM levels following VCE treatment. In conclusion, the ability of VCE to restore immune activity from an immunosuppressive state to normal levels suggests its immune-enhancing efficacy. Therefore, VCE may have the potential for application in the development of immune-enhancing functional foods and medicines. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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