المؤلفون: Tommiska, Johanna, Seal, Sheila, Renwick, Anthony, Barfoot, Rita, Baskcomb, Linda, Jayatilake, Hiran, Bartkova, Jirina, Tallila, Jonna, Kaare, Milja, Tamminen, Anitta, Heikkilä, Päivi, Evans, D. Gareth, Eccles, Diana, Aittomäki, Kristiina, Blomqvist, Carl, Bartek, Jiri, Stratton, Michael R., Nevanlinna, Heli, Rahman, Nazneen, Ardern-Jones, A., Belk, R., Berg, J., Bradshaw, N., Brice, G., Brady, A., Brewer, C., Bullman, B., Cetnarsryj, R., Chapman, C., Cole, T., Crawford, G., Cummings, C., Davidson, R., Donaldson, A., Dorkins, H., Eeles, R., Emslie, F., Evans, G., Goff, S., Gray, J., Greenhalgh, L., Gregory, H., Haites, N., Hodgson, S., Homfray, T., Houlston, R., Izatt, L., Jackson, L., Jeffers, L., Lalloo, F., Longmuir, M., McBride, D., Mackay, J., Magee, A., Mansour, S., Morrison, P., Murday, V., Paterson, J., Porteous, M., Rahman, N., Rogers, M., Rowe, S., Schofield, A., Shea-Simmonds, J., Side, L., Snadden, L.

المصدر: Tommiska , J , Seal , S , Renwick , A , Barfoot , R , Baskcomb , L , Jayatilake , H , Bartkova , J , Tallila , J , Kaare , M , Tamminen , A , Heikkilä , P , Evans , D G , Eccles , D , Aittomäki , K , Blomqvist , C , Bartek , J , Stratton , M R , Nevanlinna , H , Rahman , N , Ardern-Jones , A , Belk , R , Berg , J , Bradshaw , N , Brice , G , Brady ....

مصطلحات موضوعية: Breast cancer, Cancer susceptibility, Familial, RAD50

الإتاحة: https://doi.org/10.1002/ijc.21738Test
https://kclpure.kcl.ac.uk/portal/en/publications/4bebabfe-1e86-4b74-9b26-54505cd590f5Test

المؤلفون: Cromm, Philipp M., Crews, Craig M., Mainolfi, Nello, Rasmusson, Tim, Poulikakos, Poulikos I., Zhang, Chao, Bollag, Gideon, Shokat, Kevan M., Rosen, Neal, Agianian, Bogos, Gavathiotis, Evripidis, Raina, Kanak, Durrant, David E., Morrison, Deborah K., Neklesa, Taavi K., Winkler, James D., Chang, F., Steelman, L. S., Lee, J. T., Shelton, J. G., Navolanic, P. M., Blalock, W. L., Franklin, R. A., McCubrey, J. A., Burslem, George M., Smith, Blake E., Lai, Ashton C., Jaime-Figueroa, Saul, McQuaid, Daniel C., Bondeson, Daniel P., Toure, Momar, Dong, Hanqing, Qian, Yimin, Wang, Jing, Crew, Andrew P., Hines, John, Sanchez, Jaquelyn N., Wang, Ton, Cohen, Mark S., Shelledy, PharmD, Lindsay, Roman, PharmD, BCOP, Danielle, Davies, Helen, Bignell, Graham R., Cox, Charles, Stephens, Philip, Edkins, Sarah, Clegg, Sheila, Teague, Jon, Woffendin, Hayley, Garnett, Mathew J., Bottomley, William, Davis, Neil, Dicks, Ed, Ewing, Rebecca, Floyd, Yvonne, Gray, Kristian, Hall, Sarah, Hawes, Rachel, Hughes, Jaime, Kosmidou, Vivian, Menzies, Andrew, Mould, Catherine, Parker, Adrian, Stevens, Claire, Watt, Stephen, Hooper, Steven, Jayatilake, Hiran, Gusterson, Barry A., Cooper, Colin, Shipley, Janet, Hargrave, Darren, Pritchard-Jones, Katherine, Maitland, Norman, Chenevix-Trench, Georgia, Riggins, Gregory J., Bigner, Darell D., Palmieri, Giuseppe, Cossu, Antonio, Flanagan, Adrienne, Nicholson, Andrew, Ho, Judy W.C., Leung, Suet Y., Yuen, Siu T., Weber, Barbara L., Seigler, Hilliard F., Darrow, Timothy L., Paterson, Hugh, Wooster, Richard, Stratton, Michael R., Futreal, P. Andrew, Spevak, Wayne, Zhang, Ying, Burton, Elizabeth A., Ma, Yan, Habets, Gaston, Zhang, Jiazhong, Lin, Jack, Ewing, Todd, Matusow, Bernice, Tsang, Garson, Marimuthu, Adhirai, Cho, Hanna, Wu, Guoxian, Wang, Weiru, Fong, Daniel, Nguyen, Hoa, Shi, Songyuan, Womack, Patrick, Nespi, Marika, Shellooe, Rafe, Carias, Heidi, Powell, Ben, Light, Emily, Sanftner, Laura, Walters, Jason, Tsai, James, West, Brian L., Visor, Gary, Rezaei, Hamid, Lin, Paul S., Nolop, Keith, Ibrahim, Prabha N., Hirth, Peter, Arozarena, Imanol, Wellbrock, Claudia, Samatar, Ahmed A., Karoulia, Zoi, Chapman, Paul B., Hauschild, Axel, Robert, Caroline, Haanen, John B., Ascierto, Paolo, Larkin, James, Dummer, Reinhard, Garbe, Claus, Testori, Alessandro, Maio, Michele, Hogg, David, Lorigan, Paul, Lebbe, Celeste, Jouary, Thomas, Schadendorf, Dirk, Ribas, Antoni, O'Day, Steven J., Sosman, Jeffrey A., Kirkwood, John M., Eggermont, Alexander M.M., Dreno, Brigitte, Li, Jiang, Nelson, Betty, Hou, Jeannie, Lee, Richard J., Flaherty, Keith T., McArthur, Grant A., Vogelstein, Bert, Papadopoulos, Nickolas, Velculescu, Victor E., Zhou, Shibin, Diaz, Luis A., Kinzler, Kenneth W., Millington, G. W.M., Buhimschi, Alexandru D., Hamman, Brian D., Ishchenko, Alexey

المصدر: Cromm, P M, Crews, C M, Mainolfi, N, Rasmusson, T, Poulikakos, P I, Zhang, C, Bollag, G, Shokat, K M, Rosen, N, Crews, C M, Agianian, B, Gavathiotis, E, Raina, K, Crews, C M, Durrant, D E, Morrison, D K, Neklesa, T K, Winkler, J D, Crews, C M, Chang, F, Steelman, L S, Lee, J T, Shelton, J G, Navolanic, P M, Blalock, W L, Franklin, R A, McCubrey, J A, Burslem, G M, Smith, B E, Lai, A C, Jaime-Figueroa, S, McQuaid, D C, Bondeson, D P, Toure, M, Dong, H, Qian, Y, Wang, J, Crew, A P, Hines, J, Crews, C M, Sanchez, J N, Wang, T, Cohen, M S, Shelledy, PharmD, L, Roman, PharmD, BCOP, D, Davies, H, Bignell, G R, Cox, C, Stephens, P, Edkins, S, Clegg, S, Teague, J, Woffendin, H, Garnett, M J, Bottomley, W, Davis, N, Dicks, E, Ewing, R, Floyd, Y, Gray, K, Hall, S, Hawes, R, Hughes, J, Kosmidou, V, Menzies, A, Mould, C, Parker, A, Stevens, C, Watt, S, Hooper, S, Jayatilake, H, Gusterson, B A, Cooper, C, Shipley, J, Hargrave, D, Pritchard-Jones, K, Maitland, N, Chenevix-Trench, G, Riggins, G J, Bigner, D D, Palmieri, G, Cossu, A, Flanagan, A, Nicholson, A, Ho, J W C, Leung, S Y, Yuen, S T, Weber, B L, Seigler, H F, Darrow, T L, Paterson, H, Wooster, R, Wooster, R, Stratton, M R, Futreal, P A, Zhang, C, Spevak, W, Zhang, Y, Burton, E A, Ma, Y, Habets, G, Zhang, J, Lin, J, Ewing, T, Matusow, B, Tsang, G, Marimuthu, A, Cho, H, Wu, G, Wang, W, Fong, D, Nguyen, H, Shi, S, Womack, P, Nespi, M, Shellooe, R, Carias, H, Powell, B, Light, E, Sanftner, L, Walters, J, Tsai, J, West, B L, Visor, G, Rezaei, H, Lin, P S, Nolop, K, Ibrahim, P N, Hirth, P, Bollag, G, Arozarena, I, Wellbrock, C, Samatar, A A, Poulikakos, P I, Karoulia, Z, Gavathiotis, E, Poulikakos, P I, Chapman, P B, Hauschild, A, Robert, C, Haanen, J B, Ascierto, P, Larkin, J, Dummer, R, Garbe, C, Testori, A, Maio, M, Hogg, D, Lorigan, P, Lebbe, C, Jouary, T, Schadendorf, D, Ribas, A, O'Day, S J, Sosman, J A, Kirkwood, J M, Eggermont, A M M, Dreno, B, Nolop, K, Li, J, Nelson, B, Hou, J, Lee, R J, Flaherty, K T, McArthur, G A, Vogelstein, B, Papadopoulos, N, Velculescu, V E, Zhou, S, Diaz, L A, Kinzler, K W, Millington, G W M, Bondeson, D P, Smith, B E, Burslem, G M, Buhimschi, A D, Hines, J, Jaime-Figueroa, S, Wang, J, Hamman, B D, Ishchenko, A & Crews, C M 2018, ' The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study ', Cell Chemical Biology, pp. 67-77.e3 . https://doi.org/10.1016/j.chembiol.2017.09.009Test

مصطلحات موضوعية: 0301 basic medicine, Small molecular weight membrane-permeable inhibito, MAPK/p38, selective degradation, Raf kinases, Clinical Biochemistry, Receptor Protein-Tyrosine Kinases, protein-protein interactions, Signal transduction, Ligands, ERK cascade, protein dimerisation, Biochemistry, ternary complex, Receptor tyrosine kinase, Therapeutic intervention, 0302 clinical medicine, PROTACs, Drug Discovery, Kinome, Enzyme Inhibitors, Cereblon, E3 ligase, SNIPER, receptor tyrosine kinases, Manchester Cancer Research Centre, biology, Ras pathway, targeted degradation, Ubiquitin ligase, Raf inhibitors, 030220 oncology & carcinogenesis, Cytokines, cancer therapy, Molecular Medicine, Protein family, Ubiquitin-Protein Ligases, EGFR, hydrophobic tagging, Undruggable proteome, chemical biology, Protein degradation, Article, PROTAC, 03 medical and health sciences, proteomics, HER2, VHL, Humans, Molecular Biology, c-Met, Pharmacology, Heterobifunctional degrader, ResearchInstitutes_Networks_Beacons/mcrc, Proteolysis targeting chimera, Ubiquitination, Oncogenes, 030104 developmental biology, MAPK kinase cascade, CRBN, Proteolysis, biology.protein, Targeted protein degradation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361df2b1e3e643d7e80d0d128cb88ce3Test
https://doi.org/10.1016/j.chembiol.2017.09.009Test

المؤلفون: Rahman, Nazneen, Seal, Sheila, Thompson, Deborah, Kelly, Patrick, Renwick, Anthony, Elliott, Anna, Reid, Sarah, Spanova, Katarina, Barfoot, Rita, Chagtai, Tasnim, Jayatilake, Hiran, McGuffog, Lesley, Hanks, Sandra, Evans, D. Gareth, Eccles, Diana, Easton, Douglas F., Stratton, Michael R.

العلاقة: Rahman, Nazneen, Seal, Sheila, Thompson, Deborah, Kelly, Patrick, Renwick, Anthony, Elliott, Anna, Reid, Sarah, Spanova, Katarina, Barfoot, Rita, Chagtai, Tasnim, Jayatilake, Hiran, McGuffog, Lesley, Hanks, Sandra, Evans, D. Gareth, Eccles, Diana, Easton, Douglas F. and Stratton, Michael R. , The Breast Cancer Susceptibility Collaboration (UK) (2007) PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nature Genetics, 39 (2), 165-167. (doi:10.1038/ng1959 ).

الإتاحة: https://doi.org/10.1038/ng1959Test
https://eprints.soton.ac.uk/44355Test/

المؤلفون: Seal, Sheila, Thompson, Deborah, Renwick, Anthony, Elliott, Anna, Kelly, Patrick, Barfoot, Rita, Chagtai, Tasnim, Jayatilake, Hiran, Ahmed, Munaza, Spanova, Katarina, North, Bernard, McGuffog, Lesley, Evans, D. Gareth, Eccles, Diana, Easton, Douglas F., Stratton, Michael R., Rahman, Nazneen

العلاقة: Seal, Sheila, Thompson, Deborah, Renwick, Anthony, Elliott, Anna, Kelly, Patrick, Barfoot, Rita, Chagtai, Tasnim, Jayatilake, Hiran, Ahmed, Munaza, Spanova, Katarina, North, Bernard, McGuffog, Lesley, Evans, D. Gareth, Eccles, Diana, Easton, Douglas F., Stratton, Michael R. and Rahman, Nazneen (2006) Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles. Nature Genetics, 38 (11), 1239-1241. (doi:10.1038/ng1902 ).

الإتاحة: https://doi.org/10.1038/ng1902Test
https://eprints.soton.ac.uk/62921Test/

المؤلفون: Renwick, Anthony, Thompson, Deborah, Seal, Sheila, Kelly, Patrick, Chagtai, Tasnim, Ahmed, Munaza, North, Bernard, Jayatilake, Hiran, Barfoot, Rita, Spanova, Katarina, McGuffog, Lesley, Evans, D. Gareth, Eccles, Diana, Easton, Douglas F., Stratton, Michael R., Rahman, Nazneen

العلاقة: Renwick, Anthony, Thompson, Deborah, Seal, Sheila, Kelly, Patrick, Chagtai, Tasnim, Ahmed, Munaza, North, Bernard, Jayatilake, Hiran, Barfoot, Rita, Spanova, Katarina, McGuffog, Lesley, Evans, D. Gareth, Eccles, Diana, Easton, Douglas F., Stratton, Michael R. and Rahman, Nazneen , Breast Cancer Susceptibility Collaboration (UK) (2006) ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. Nature Genetics, 38 (8), 873-875. (doi:10.1038/ng1837 ).

الإتاحة: https://doi.org/10.1038/ng1837Test
https://eprints.soton.ac.uk/45377Test/

المؤلفون: Rahman, Nazneen, Seal, Sheila, Thompson, Deborah, Kelly, Patrick, Renwick, Anthony, Elliott, Anna, Reid, Sarah, Spanova, Katarina, Barfoot, Rita, Chagtai, Tasnim, Jayatilake, Hiran, McGuffog, Lesley, Hanks, Sandra, Evans, D Gareth, Eccles, Diana, Easton, Douglas F, Stratton, Michael R

المصدر: Nature Genetics ; volume 39, issue 2, page 165-167 ; ISSN 1061-4036 1546-1718

مصطلحات موضوعية: Genetics

الإتاحة: https://doi.org/10.1038/ng1959Test
http://www.nature.com/articles/ng1959.pdfTest
http://www.nature.com/articles/ng1959Test

المؤلفون: Seal, Sheila, Barfoot, Rita, Jayatilake, Hiran, Smith, Paula, Renwick, Anthony, Bascombe, Linda, McGuffog, Lesley, Evans, D. Gareth, Eccles, Diana, Easton, Douglas F., Stratton, Michael R., Rahman, Nazneen

العلاقة: Seal, Sheila, Barfoot, Rita, Jayatilake, Hiran, Smith, Paula, Renwick, Anthony, Bascombe, Linda, McGuffog, Lesley, Evans, D. Gareth, Eccles, Diana, Easton, Douglas F., Stratton, Michael R. and Rahman, Nazneen (2003) Evaluation of Fanconi Anemia genes in familial breast cancer predisposition. Cancer Research, 63 (24), 8596-8599.

الإتاحة: https://eprints.soton.ac.uk/26599Test/
http://cancerres.aacrjournals.org/cgi/content/abstract/63/24/8596Test

المؤلفون: Davies, Helen, Bignell, Graham R, Cox, Charles, Stephens, Philip, Edkins, Sarah, Clegg, Sheila, Teague, Jon, Woffendin, Hayley, Garnett, Mathew J, Bottomley, William, Davis, Neil, Dicks, Ed, Ewing, Rebecca, Floyd, Yvonne, Gray, Kristian, Hawes, Rachel, Hughes, Jaime, Kosmidou, Vivian, Menzies, Andrew, Mould, Catherine, Parker, Adrian, Stevens, Claire, Watt, Stephen, Wilson, Rebecca, Jayatilake, Hiran, Gusterson, Barry A, Cooper, Colin, Shipley, Janet, Hargrave, Darren, Pritchard-Jones, Katherine, Maitland, Norman, Chenevix-Trench, Georgia, Riggins, Gregory J, Bigner, Darell D, Palmieri, Giuseppe, Cossu, Antonio, Flanagan, Adrienne, Nicholson, Andrew, Ho, Judy W C, Leung, Suet Y, Yuen, Siu T, Weber, Barbara L, Seigler, Hilliard F, Darrow, Timothy L, Paterson, Hugh, Marais, Richard, Marshall, Christopher J, Wooster, Richard, Stratton, Michael R, Futreal, P Andrew

العلاقة: Davies, Helen, Bignell, Graham R, Cox, Charles, Stephens, Philip, Edkins, Sarah, Clegg, Sheila, Teague, Jon, Woffendin, Hayley, Garnett, Mathew J, Bottomley, William, Davis, Neil, Dicks, Ed, Ewing, Rebecca, Floyd, Yvonne, Gray, Kristian, Hawes, Rachel, Hughes, Jaime, Kosmidou, Vivian, Menzies, Andrew, Mould, Catherine, Parker, Adrian, Stevens, Claire, Watt, Stephen, Wilson, Rebecca, Jayatilake, Hiran, Gusterson, Barry A, Cooper, Colin, Shipley, Janet, Hargrave, Darren, Pritchard-Jones, Katherine, Maitland, Norman, Chenevix-Trench, Georgia, Riggins, Gregory J, Bigner, Darell D, Palmieri, Giuseppe, Cossu, Antonio, Flanagan, Adrienne, Nicholson, Andrew, Ho, Judy W C, Leung, Suet Y, Yuen, Siu T, Weber, Barbara L, Seigler, Hilliard F, Darrow, Timothy L, Paterson, Hugh, Marais, Richard, Marshall, Christopher J, Wooster, Richard, Stratton, Michael R and Futreal, P Andrew (2002) Mutations of the BRAF gene in human cancer. Nature, 417 (6892). pp. 949-54. ISSN 0028-0836

الإتاحة: https://doi.org/10.1038/nature00766Test
https://ueaeprints.uea.ac.uk/id/eprint/46170Test/

المؤلفون: Locke, Darren, Perusinghe, Nina, Newman, Terry, Jayatilake, Hiran, Evans, W. Howard, Monaghan, Paul

المصدر: Journal of Cellular Physiology ; volume 183, issue 2, page 228-237 ; ISSN 0021-9541 1097-4652

الإتاحة: https://doi.org/10.1002Test/(sici)1097-4652(200005)183:2%3C228::aid-jcp9%3E3.0.co%3B2-y

المؤلفون: Smalley, Matthew John, Fraser, Elizabeth, Paterson, Hugh, Naylor, Stuart, Cook, David, Jayatilake, Hiran, Fryer, Lee G., Hutchinson, Lisa, Fry, Michael J., Dale, Trevor C.

العلاقة: Smalley, Matthew John https://orca.cardiff.ac.uk/view/cardiffauthors/A3534339.htmlTest orcid:0000-0001-9540-1146 orcid:0000-0001-9540-1146, Fraser, Elizabeth https://orca.cardiff.ac.uk/view/cardiffauthors/A019816A.htmlTest, Paterson, Hugh, Naylor, Stuart, Cook, David, Jayatilake, Hiran, Fryer, Lee G., Hutchinson, Lisa, Fry, Michael J. and Dale, Trevor C. 1999. Interaction of Axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription. EMBO Journal 18 (10) , pp. 2823-2835. 10.1093/emboj/18.10.2823 https://doi.org/10.1093/emboj%2F18.10.2823Test

الإتاحة: https://doi.org/10.1093/emboj/18.10.2823Test
https://orca.cardiff.ac.uk/id/eprint/64565Test/