High dosage of zinc modulates T-cells in a time-dependent manner within porcine gut-associated lymphatic tissue
| العنوان: | High dosage of zinc modulates T-cells in a time-dependent manner within porcine gut-associated lymphatic tissue |
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| المؤلفون: | Paula Korkuć, Robert Pieper, Gudrun A. Brockmann, Nadine Wöltje, Susanne Kreuzer-Redmer, Volker Gerdts, François Meurens, Deike Hesse, Danny Arends, Jürgen Zentek, Jasper N. Schulte, Diana Karweina |
| المساهمون: | Albrecht Daniel Thaer-Institut für Agrar- und Gartenbauwissenschaften, Humboldt-Universität zu Berlin, Partenaires INRAE, University of Veterinary Medicine [Vienna] (Vetmeduni), Freie Universität Berlin, University of Saskatchewan, Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), Institut National de la Recherche Agronomique (INRA) |
| المصدر: | British Journal of Nutrition British Journal of Nutrition, Cambridge University Press (CUP), 2018, 120 (12), pp.1349-1358. ⟨10.1017/S0007114518002908⟩ |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, CD4-Positive T-Lymphocytes, Male, Swine, [SDV]Life Sciences [q-bio], Cell, Sus scrofa, GATA binding protein 3, Medicine (miscellaneous), Lymphatic tissues, CD8-Positive T-Lymphocytes, T-box 21, Mesenteric lymph node, Interferon γ, Leukocytes, Medium Zn concentration, Micronutrients, Solute carrier family 39 member 4 (SLC39A4), Nutrition and Dietetics, FOXP3, Solute carrier family 30 (SLC30), Intestines, Zinc, Low Zn concentration, medicine.anatomical_structure, High dosage, Cytokines, Pigs, Female, Zinc Oxide, High Zn concentration, Gene set enrichment analysis, Forkhead box P3, Interferon y, Lymphoid Tissue, Feed additive, chemistry.chemical_element, Weaning, Andrology, 03 medical and health sciences, Immune system, medicine, Animals, Gut-associated lymphatic tissue, Sequence Analysis, RNA, T-cells, Body weight, Th1 Cells, Animal Feed, Diet, 030104 developmental biology, chemistry, Gene Expression Regulation, Immune System, Nutritional immune response |
| الوصف: | Zn serves as a powerful feed additive to reduce post-weaning diarrhoea in pigs. However, the mechanisms responsible for Zn-associated effects on the adaptive immune responses following feeding of a very high dosage of Zn remain elusive. In this study, we examined the T-cell response in gut-associated lymphatic tissues of seventy-two weaned piglets. Piglets received diets with 57 mg Zn/kg (low Zn concentration, LZn), 164 mg Zn/kg (medium Zn concentration, MZn) or 2425 mg Zn/kg (high Zn concentration, HZn) mg Zn/kg feed for 1, 2 or 4 weeks. We observed that feeding the HZn diet for 1 week increased the level of activated T-helper cells (CD4+ and CD8αdim) compared with feeding MZn and LZn (Pγ and T-box 21 (TBET) in the HZn group compared with the MZn and LZn groups (P+CD25high regulatory T-helper cells (PFOXP3) transcripts (P+ T-cell count (Pβ+ T-cell count (P |
| تدمد: | 1475-2662 0007-1145 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318f1da16c99ce6088c70250ed511bfbTest https://pubmed.ncbi.nlm.nih.gov/30387407Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....318f1da16c99ce6088c70250ed511bfb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752662 00071145 |
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