التفاصيل البيبلوغرافية
| العنوان: |
HYPERREFLECTIVE FOCI NOT SEEN AS HYPERPIGMENTARY ABNORMALITIES ON COLOR FUNDUS PHOTOGRAPHS IN AGE-RELATED MACULAR DEGENERATION |
| المؤلفون: |
Goh, Kai Lyn, Wintergerst, Maximilian W. M., Abbott, Carla J., Hadoux, Xavier, Jannaud, Maxime, Kumar, Himeesh, Hodgson, Lauren A. B., Guzman, Gabriela, Janzen, Simon, van Wijngaarden, Peter, Finger, Robert P., Guymer, Robyn H., Wu, Zhichao |
| المساهمون: |
National Health and Medical Research Council, Macular Disease Foundation Australia, BrightFocus Foundation, Ernst und Berta Grimmke Stiftung, H&L Hecht Trust, Centre for Eye Research Australia Innovation Fund |
| المصدر: |
Retina ; volume 44, issue 2, page 214-221 ; ISSN 0275-004X |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2024 |
| الوصف: |
Purpose: To investigate the prognostic value of quantifying optical coherence tomography (OCT)-defined hyperreflective foci (HRF) that do not correspond to hyperpigmentary abnormalities (HPAs) on color fundus photographs (CFPs)—HRF (OCT+/CFP−) —when considered in addition to HPA extent, for predicting late age-related macular degeneration development. This study sought to understand the impact of HRF (OCT+/CFP−) extent on visual sensitivity. Methods: Two hundred eighty eyes from 140 participants with bilateral large drusen underwent imaging and microperimetry at baseline, and then 6-monthly for 3-years. The extent of HPAs on CFPs and HRF (OCT+/CFP−) on OCT was quantified at baseline. Predictive models for progression to late age-related macular degeneration, accounting for drusen volume and age, were developed using HPA extent, with and without HRF (OCT+/CFP−) extent. The association between HPA and HRF (OCT+/CFP−) extent with sector-based visual sensitivity was also evaluated. Results: Incorporating HRF (OCT+/CFP−) extent did not improve the predictive performance for late age-related macular degeneration development ( P ≥ 0.32). Increasing HPA and HRF (OCT+/CFP−) extent in each sector were independently and significantly associated with reduced sector-based visual sensitivity ( P ≤ 0.004). Conclusion: The addition of HRF (OCT+/CFP−) extent to HPA extent did not improve the prediction of late age-related macular degeneration development. HRF (OCT+/CFP−) extent was also independently associated with local reductions in visual sensitivity, after accounting for HPAs. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1097/iae.0000000000003958 |
| DOI: |
10.1097/IAE.0000000000003958 |
| الإتاحة: |
https://doi.org/10.1097/iae.0000000000003958Test |
| رقم الانضمام: |
edsbas.8A3596EB |
| قاعدة البيانات: |
BASE |
