المؤلفون: Koen Dudink, Pim Aarts, Hessel H. van der Zee, Christine B. Ardon, Allard R. J. V. Vossen, Kelsey R. van Straalen, Errol P. Prens

المصدر: Drugs

مصطلحات موضوعية: Drug, media_common.quotation_subject, Review Article, Disease, Antibodies, Monoclonal, Humanized, Interleukin-23, Severity of Illness Index, Receptors, Interleukin-8B, Etanercept, Receptors, Interleukin-8A, Pharmacotherapy, medicine, Adalimumab, Humans, Immunologic Factors, Janus Kinase Inhibitors, Pharmacology (medical), Hidradenitis suppurativa, CD40 Antigens, Protein Kinase Inhibitors, media_common, Epoxide Hydrolases, Biological Products, business.industry, Interleukin-17, medicine.disease, Small molecule, Infliximab, Anti-Bacterial Agents, Hidradenitis Suppurativa, Thalidomide, Clinical trial, Interleukin 1 Receptor Antagonist Protein, Complement Inactivating Agents, Surgical Procedures, Operative, Immunology, Tumor Necrosis Factor Inhibitors, business, Interleukin-1, Janus Kinase Family, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748e5f5f79e8b427a483fa970122aadfTest
https://doi.org/10.1007/s40265-021-01566-2Test

المؤلفون: Ikko Kajihara, Hisashi Kanemaru, Soichiro Sawamura, Shinichi Masuguchi, Katsunari Makino, Kayo Kashiwada-Nakamura, Jun Aoi, Tselmeg Mijiddorj Myangat, Satoshi Fukushima

المصدر: The Journal of dermatologyREFERENCES. 49(3)

مصطلحات موضوعية: DNA Copy Number Variations, Chemistry, Dermatology, General Medicine, DNA, Janus Kinase 1, Janus Kinase 2, medicine.disease, Free dna, Molecular biology, chemistry.chemical_compound, Psoriasis, medicine, Humans, Cell-Free Nucleic Acids, Janus Kinase Family, Janus Kinases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff6532bc5a10319f5b665a0b9646dddTest
https://pubmed.ncbi.nlm.nih.gov/34796989Test

المؤلفون: Xingrong Liu, Nico Ghilardi, Simon Charles Goodacre, Michael Siu, Jim Nonomiya, G. Buckley, Adam R. Johnson, Yun-Xing Cheng, F.A. Romero, Nick Ray, Rohan Mendonca, C. Robinson, Yuen Po-Wai, Jane R. Kenny, Marya Liimatta, Terry Kellar, Mark Zak, Gary Salmon, J. Lloyd, D.G. Brown, Neville James Mclean, Joseph P. Lyssikatos, Emily J. Hanan, Patrick J. Lupardus, Pawan Bir Kohli, Christopher A. Hurley, Guiling Zhao, Paul Gibbons, Peter H. Crackett

المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1522-1531

مصطلحات موضوعية: Receptor complex, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, Dermatitis, Atopic, Allergic inflammation, Drug Discovery, Humans, Molecular Biology, Interleukin-13, Janus kinase 1, 010405 organic chemistry, Chemistry, Organic Chemistry, Janus Kinase 1, Janus Kinase 2, Small molecule, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Tyrosine kinase 2, Interleukin 13, Cancer research, Molecular Medicine, Janus kinase, Signal Transduction, Janus Kinase Family

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e867a785065ce94ed8447c01ad10c0Test
https://doi.org/10.1016/j.bmcl.2019.04.008Test

المؤلفون: Michael D. Howell, Fiona Kuo, Paul Smith

المصدر: Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology

مصطلحات موضوعية: 0301 basic medicine, lcsh:Immunologic diseases. Allergy, Immunology, Vitiligo, Review, medicine.disease_cause, Skin Diseases, stat, Autoimmunity, Autoimmune Diseases, 03 medical and health sciences, 0302 clinical medicine, Psoriasis, medicine, Immunology and Allergy, Humans, Janus Kinase Inhibitors, skin barrier, Janus Kinases, business.industry, autoimmunity, Atopic dermatitis, Alopecia areata, medicine.disease, cytokines, dermatology, STAT Transcription Factors, 030104 developmental biology, Cancer research, Janus kinase, business, lcsh:RC581-607, 030215 immunology, Janus Kinase Family, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187c13730696e0ffe42e1d11b498644eTest
https://www.frontiersin.org/article/10.3389/fimmu.2019.02342/fullTest

المؤلفون: Juuli Raivola, Olli Silvennoinen, Henrik Hammaren, Pelin Ayaz, Yibing Shan, Dina Sharon, Stevan R. Hubbard, David E. Shaw

مصطلحات موضوعية: 0303 health sciences, Chemistry, Kinase, medicine.medical_treatment, Mutant, Constitutively active, Mutagenesis (molecular biology technique), Dual effect, Cell biology, 03 medical and health sciences, 0302 clinical medicine, Cytokine, hemic and lymphatic diseases, 030220 oncology & carcinogenesis, medicine, Receptor, 030304 developmental biology, Janus Kinase Family

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365bbce773fccd19d99fc95bac0ea0b0Test
https://doi.org/10.1101/727727Test

المؤلفون: Daniel Thomas, Tom A. Fleming, Martin-Immanuel Bittner

المصدر: Cancer Research. 81:295-295

مصطلحات موضوعية: Profiling (computer programming), Cancer Research, Oncology, Fully automated, Coronavirus disease 2019 (COVID-19), Computer science, Kinase, Drug discovery, Tyrosine kinase 2, Assay, Computational biology, Janus Kinase Family

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7ec7c99dfc0c931a258e01c11f7bb6bbTest
https://doi.org/10.1158/1538-7445.am2021-295Test

المؤلفون: Manon E. Wildenberg, G R D’Haens, W J de Jonge, L.C.S. De Vries

المصدر: J Crohns Colitis
Journal of Crohn's & Colitis

مصطلحات موضوعية: Crohn’s disease, 0301 basic medicine, Filgotinib, filgotinib, Review Article, Inflammatory bowel disease, 03 medical and health sciences, 0302 clinical medicine, Piperidines, medicine, Animals, Humans, Janus Kinase Inhibitors, Pyrroles, ulcerative colitis, Janus Kinases, Crohn's disease, tofacitinib, Tofacitinib, Janus kinase 1, business.industry, Gastroenterology, General Medicine, Inflammatory Bowel Diseases, medicine.disease, Ulcerative colitis, STAT Transcription Factors, Pyrimidines, 030104 developmental biology, Kinase inhibitors, Mutation, Cancer research, Cytokines, 030211 gastroenterology & hepatology, Corrigendum, Janus kinase, business, Signal Transduction, Janus Kinase Family

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb0e0a72624734523e6ce974a264497Test
https://doi.org/10.1093/ecco-jcc/jjx003Test

المؤلفون: LiXi Yang, Glynn Addison, Jun Dai

المصدر: Mini reviews in medicinal chemistry. 19(18)

مصطلحات موضوعية: Drug Evaluation, Preclinical, 01 natural sciences, Autoimmune Diseases, 03 medical and health sciences, Residue (chemistry), Immune system, Drug Discovery, Benzene Derivatives, Humans, Protein Kinase Inhibitors, 030304 developmental biology, Pharmacology, 0303 health sciences, Tofacitinib, 010405 organic chemistry, Chemistry, Janus kinase 3, Janus Kinase 3, General Medicine, Amides, 0104 chemical sciences, Biochemistry, Covalent bond, Tyrosine kinase 2, Cysteine, Janus Kinase Family, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55b08c5934c3dc3db717c1e9a67b41aTest
https://pubmed.ncbi.nlm.nih.gov/31288716Test

المؤلفون: Enrique Esteve-Valverde, Jaume Alijotas-Reig, Josep Pardos-Gea, Ariadna Anunciacion-Llunell, Cristina Belizna, Angela Quintana, Arsène Mekinian, Francesc Miró-Mur, Albert Selva-O'Callaghan

المصدر: Autoimmunity Reviews

مصطلحات موضوعية: 0301 basic medicine, SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus-2, PTE, Pulmonary thromboembolism, Angiotensin-Converting Enzyme Inhibitors, TGF-β, Transforming growth factor-beta, Cytokine storm, medicine.disease_cause, Immunosuppressive, Pathogenesis, MERS-CoV, Middle East Respiratory Syndrome Coronavirus, 0302 clinical medicine, Risk Factors, HCQ, Hydroxychloroquine, Immunology and Allergy, CQ, Chloroquine, IL, Interleukin, NHC, National Health Council, mTOR, Mammalian target of Rapamycin, Coronavirus, COVID-19, Coronavirus disease 2019, Acute respiratory distress syndrome, RA, Rheumatoid arthritis, aPL, Antiphospholipid antibodies, Immunoglobulins, Intravenous, APC, Antigen-presenting cells, CDC, Centres for disease control, PIC, Pulmonary intravascular coagulation, Cytokines, TLR, Toll-Like Receptor, medicine.symptom, Coronavirus Infections, JAK, Janus-Kinase family of enzymes (JAK1, JAK2, JAK3, TYK2), medicine.drug, CyA, Cyclosporine A, TNF-α, Tumour necrosis factor-alpha, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Immunology, Inflammation, Antiviral Agents, Article, NK, natural killer cells, WHO, World Health Organization, IFNγ, Interferon gamma, LMWH, Low-molecular weight heparin, Immunomodulation, Antimalarials, Betacoronavirus, 03 medical and health sciences, GCS, Glucocorticoids, ACE-2, Angiotensin-converting enzyme-2, ADE, Antibody dependent enhancement, medicine, Humans, TCZ, Tocilizumab, Glucocorticoids, Pandemics, Janus Kinases, TRAASVIR, Thrombotic Risk Associated with Antiphospholipid Syndrome after Viral infection, 030203 arthritis & rheumatology, SARS-CoV-2, AD, Autoimmune diseases, business.industry, SLE, Systemic Lupus Erythematosus, COVID-19, Anticoagulants, Hydroxychloroquine, medicine.disease, Tregs, Regulatory T-cells, HPS, Haemophagocytic syndrome, Treatment, Calcineurin, 030104 developmental biology, ADRS, Acute distress respiratory syndrome, MHC-II, Major histocompatibility type-II, IVIG, Intravenous immunoglobulins, CD, Cluster of differentiation or cluster of designation or classification determinant, FDA, Food and Drugs Administration, MDA5, Melanoma differentiation-associated gene 5, MAS, Macrophage activation syndrome, NF-kβ, Nuclear Factor-Kβ, TRALI, Transfusion-related acute lung injury, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d817ad2d95f1fb4ae20a1d806adffaTest
https://doi.org/10.1016/j.autrev.2020.102569Test

المؤلفون: Diane M. Coe, Andrei Mihut, Michelle Anne Bartholomew, Joanna M. Redmond, John P. Evans, Rishi R. Shah, John A. Murphy, Malini Menon

المصدر: Bioorganic & Medicinal Chemistry. 28:115326

مصطلحات موضوعية: THP-1 Cells, Clinical Biochemistry, Pharmaceutical Science, Ligands, Inhibitor of apoptosis, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Ubiquitin, Quinoxalines, Drug Discovery, Humans, QD, Molecular Biology, Janus Kinases, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Drug discovery, Chemistry, Cereblon, Organic Chemistry, Proteolysis targeting chimera, JAK-STAT signaling pathway, 0104 chemical sciences, Cell biology, STAT Transcription Factors, 010404 medicinal & biomolecular chemistry, Pyrimidines, Tyrosine kinase 2, Drug Design, Proteolysis, biology.protein, Molecular Medicine, Janus Kinase Family

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ddbf5bcb860bd75799cc32b7f74012Test
https://doi.org/10.1016/j.bmc.2020.115326Test