المؤلفون: Hong Xiang, Abigael G. Chan, Ago Ahene, David I. Bellovin, Rong Deng, Amy W. Hsu, Ursula Jeffry, Servando Palencia, Janine Powers, James Zanghi, Helen Collins

المصدر: mAbs, Vol 13, Iss 1 (2021)

مصطلحات موضوعية: Bemarituzumab, anti-FGFR2b antibody, fibroblast growth factor receptor, pharmacokinetics, toxicology, afucosylated antibody, antibody-dependent cell-mediated cytoxicity, phosphorylation in vitro, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1942-0862Test; https://doaj.org/toc/1942-0870Test

الوصول الحر: https://doaj.org/article/631148f01f704dc69b35977cd33a11deTest

المؤلفون: Daniel W. Robbins, Mark A. Noviski, Ying Siow Tan, Zef A. Konst, Aileen Kelly, Paul Auger, Nivetha Brathaban, Robert Cass, Ming Liang Chan, Ganesh Cherala, Matthew C. Clifton, Stefan Gajewski, Timothy G. Ingallinera, Dane Karr, Daisuke Kato, Jun Ma, Jenny McKinnell, Joel McIntosh, Jeff Mihalic, Brent Murphy, Jaipal Reddy Panga, Ge Peng, Janine Powers, Luz Perez, Ryan Rountree, Austin Tenn-McClellan, Arthur T. Sands, Dahlia R. Weiss, Jeffrey Wu, Jordan Ye, Cristiana Guiducci, Gwenn Hansen, Frederick Cohen

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Virology, Computational Biology, Chemical Sciences not elsewhere classified, transcription factors ikzf1, molecular glue interactions, human clinical trials, attractive therapeutic target, preclinical oncology models, many hematological malignancies, degradation across species, concomitant immunomodulatory activity, btk enzymatic function, orally bioavailable degrader, mediated bcr signaling, orally bioavailable, immunomodulatory activity, preclinical pharmacology, btk degrader, vivo <, tyrosine kinase

العلاقة: https://figshare.com/articles/journal_contribution/Discovery_and_Preclinical_Pharmacology_of_NX-2127_an_Orally_Bioavailable_Degrader_of_Bruton_s_Tyrosine_Kinase_with_Immunomodulatory_Activity_for_the_Treatment_of_Patients_with_B_Cell_Malignancies/25130114Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01007.s001Test
https://figshare.com/articles/journal_contribution/Discovery_and_Preclinical_Pharmacology_of_NX-2127_an_Orally_Bioavailable_Degrader_of_Bruton_s_Tyrosine_Kinase_with_Immunomodulatory_Activity_for_the_Treatment_of_Patients_with_B_Cell_Malignancies/25130114Test

المؤلفون: Skye Montoya, Jessie Bourcier, Meghan C. Thompson, Mark Noviski, May Tan, Eric Wang, Xiaoli Mi, Nivetha Brathaban, Carla Barrientos Risso, Daniel Tsai, Jordan Ye, Jacob Jahn, Gabriel Pardo, Lee Cabuhat, Ryan Notti, Alejandro Pardo, Maurizio Affer, Stephanie Yung, James Luliano, Janine Powers, Daniel W Robbins, Vindhya Nawaratne, Tulasigeri M Totiger, Camila Pena-Velasquez, Joanna M. Rhodes, Andrew D. Zelenetz, Lindsey E. Roeker, Hao Lu, Adam Linley, Anthony R. Mato, Omar Abdel-Wahab, Justin Taylor

المصدر: Blood. 140:1811-1813

مصطلحات موضوعية: Immunology, Cell Biology, Hematology, Biochemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::76b956cafd37b3de71dc99029a09890aTest
https://doi.org/10.1182/blood-2022-163268Test

المؤلفون: Sarah Whelan, Christopher Karim, Jordan Ye, Timothy Ingallinera, Ganesh Cherala, Katherine Jameson, Anja Williams, Adam Sharp, Matthew Krebs, Simon Pacey, Sarah Blagden, Ruth Plummer, Daniel Hochhauser, Jeff Evans, Johann De Bono, Janine Powers

المصدر: Regular and Young Investigator Award Abstracts.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e31320a30e212973945d14788b0555c1Test
https://doi.org/10.1136/jitc-2022-sitc2022.0777Test

المؤلفون: Mark A. Noviski, Jun Ma, Ernestine Lee, Nivetha Brathaban, May Tan, Luz Perez, Daniel W. Robbins, Austin Tenn-McClellan, Janine Powers, Gwenn Hansen, Cristiana Guiducci, Ryan Rountree

المصدر: Cancer Research. 82:1126-1126

مصطلحات موضوعية: Cancer Research, Oncology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::34a582c3a632b6672dfade8fff00f04eTest
https://doi.org/10.1158/1538-7445.am2022-1126Test

المؤلفون: Abigael G. Chan, Ago Ahene, Servando Palencia, Rong Deng, Janine Powers, James Zanghi, Amy W. Hsu, David Bellovin, Ursula Jeffry, Hong Xiang, Helen Collins

المصدر: mAbs
article-version (VoR) Version of Record

مصطلحات موضوعية: medicine.drug_class, Immunology, Antibodies, Monoclonal, Humanized, Monoclonal antibody, afucosylated antibody, antibody-dependent cell-mediated cytoxicity, phosphorylation in vitro, Mice, Pharmacokinetics, Stomach Neoplasms, Report, Cell Line, Tumor, Fibroblast Growth Factor Receptor 2b, medicine, Animals, Immunology and Allergy, Receptor, Fibroblast Growth Factor, Type 2, biology, Chemistry, Antibody-Dependent Cell Cytotoxicity, anti-tumor efficacy, Cancer, cell proliferation in vitro, anti-FGFR2b antibody, medicine.disease, Rats, Fibroblast growth factor receptor, Bemarituzumab, fibroblast growth factor receptor, biology.protein, Cancer research, Immunoglobulin G1, Antibody, pharmacokinetics, toxicology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cb68beb61c22f74f8cfc3c2ce74a9bTest
https://doi.org/10.1080/19420862.2021.1981202Test

المؤلفون: Frederick Cohen, Jennifa Gosling, Monisha Mani, Austin Tenn-McClellan, Janine Powers, Whelan Sarah Anne, Arthur T. Sands, Gwenn M. Hansen, Michael T. Lotze

المصدر: Journal for ImmunoTherapy of Cancer. 9:A107-A107

مصطلحات موضوعية: Pharmacology, Cancer Research, Adoptive cell transfer, biology, Chemistry, Tumor-infiltrating lymphocytes, Immunology, CD137, CD28, GZMB, Oncology, Granzyme, Cancer research, biology.protein, Molecular Medicine, Immunology and Allergy, Cytokine secretion, CD8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4e006f16779523570b613911cde3c180Test
https://doi.org/10.1136/jitc-2021-sitc2021.098Test

المؤلفون: Drew W. Rasco, Wei Deng, Zev A. Wainberg, Johanna C. Bendell, Keun-Wook Lee, Sun Young Rha, Daniel V.T. Catenacci, Neyssa Marina, Hong Xiang, Peter C. Enzinger, Yung-Jue Bang, Janine Powers, Jeeyun Lee

المصدر: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol 38, iss 21

مصطلحات موضوعية: 0301 basic medicine, Male, Cancer Research, Esophageal Neoplasms, Fibroblast Growth Factor, Gastroesophageal Junction Adenocarcinoma, Gastroenterology, Antineoplastic Agents, Immunological, 0302 clinical medicine, Monoclonal, 80 and over, Humanized, 6.2 Cellular and gene therapies, Cancer, Aged, 80 and over, Hematology, Middle Aged, Immunological, Oncology, 030220 oncology & carcinogenesis, 6.1 Pharmaceuticals, Female, Type 2, Receptor, Adult, medicine.medical_specialty, Clinical Trials and Supportive Activities, Clinical Sciences, Oncology and Carcinogenesis, Antineoplastic Agents, Adenocarcinoma, Antibodies, Monoclonal, Humanized, Antibodies, 03 medical and health sciences, Rare Diseases, Pharmacokinetics, Stomach Neoplasms, Clinical Research, Internal medicine, medicine, Humans, In patient, Oncology & Carcinogenesis, Receptor, Fibroblast Growth Factor, Type 2, Aged, Gastroesophageal adenocarcinoma, business.industry, Evaluation of treatments and therapeutic interventions, Clinical trial, 030104 developmental biology, Multicenter study, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86dcd660d9ac1a9b0d3486b4370893eTest
https://escholarship.org/uc/item/47d6q5nbTest

المؤلفون: Eric Cheung, Clarence Eng, Neyssa Marina, Anteneh Tesfaye, James Hnatyszyn, Aaron Scott, Daniel V.T. Catenacci, Mohamed Tejani, Peter D. Eisenberg, Janine Powers, Zev A. Wainberg

المصدر: Future oncology (London, England). 15(18)

مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Cancer Research, medicine.medical_specialty, Esophageal Neoplasms, Organoplatinum Compounds, medicine.drug_class, Leucovorin, Placebo, Monoclonal antibody, 03 medical and health sciences, 0302 clinical medicine, Gastroesophageal cancer, Clinical Protocols, Stomach Neoplasms, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Clinical endpoint, Biomarkers, Tumor, Humans, FGF Receptor, Receptor, Fibroblast Growth Factor, Type 2, business.industry, Gene Amplification, Cancer, General Medicine, medicine.disease, Bevacizumab, 030104 developmental biology, Research Design, 030220 oncology & carcinogenesis, Immunohistochemistry, Female, Esophagogastric Junction, Fluorouracil, business, Protein overexpression

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b499bff5720c28585e5dab342ee5335dTest
https://pubmed.ncbi.nlm.nih.gov/31094225Test

المؤلفون: Jennifer Tung, Luz Perez, Timothy Ingallinera, Jordan Ye, Aileen Kelly, May Tan, Ge Peng, Sasha Borodovsky, Zef Konst, Austin Tenn-McClellan, Ryan Rountree, Steve Basham, Jeffrey H. Wu, Jenny McKinnell, Dahlia Weiss, Arthur T. Sands, Cristiana Guiducci, Mark Noviski, Mcintosh Joel, Dane E Karr, Janine Powers, Daniel W. Robbins, Daisuke Kato, Anna Kolobova, Jeffrey T. Mihalic

المصدر: Blood. 136:34-34

مصطلحات موضوعية: biology, Cereblon, Immunology, Equity (finance), Financial system, Cell Biology, Hematology, Protein degradation, Biochemistry, chemistry.chemical_compound, chemistry, Ibrutinib, biology.protein, Bruton's tyrosine kinase, Acalabrutinib, Current employment, Business, Target binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::492f0dbdb2ad9ad3c62ea1d2da14dc82Test
https://doi.org/10.1182/blood-2020-141461Test