المؤلفون: William J. Meilandt, Janice A. Maloney, Jose Imperio, Guita Lalehzadeh, Tim Earr, Susan Crowell, Travis W. Bainbridge, Yanmei Lu, James A. Ernst, Reina N. Fuji, Jasvinder K. Atwal

المصدر: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Crenezumab, Amyloid β, Alzheimer’s disease, Oligomeric, Mossy fiber, Vascular amyloid, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1758-9193Test

الوصول الحر: https://doaj.org/article/bd282779d343414aa689f312c255a80fTest

المؤلفون: James A. Ernst, Tim Earr, Guita Lalehzadeh, Travis W. Bainbridge, Susan Crowell, William J. Meilandt, Jose Imperio, Reina N. Fuji, Yanmei Lu, Janice A. Maloney, Jasvinder K. Atwal

المصدر: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2019)
Alzheimer's Research & Therapy

مصطلحات موضوعية: 0301 basic medicine, Mossy fiber, Immunoprecipitation, Cognitive Neuroscience, Mice, Transgenic, Plaque, Amyloid, Vascular amyloid, Hippocampal formation, Antibodies, Monoclonal, Humanized, lcsh:RC346-429, lcsh:RC321-571, Mice, 03 medical and health sciences, 0302 clinical medicine, Oligomeric, Alzheimer Disease, In vivo, Crenezumab, medicine, Animals, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:Neurology. Diseases of the nervous system, Amyloid beta-Peptides, LAMP1, Chemistry, Research, Neurotoxicity, Brain, Amyloid β, medicine.disease, In vitro, Cell biology, 030104 developmental biology, Neurology, Mechanism of action, Neurology (clinical), medicine.symptom, Alzheimer’s disease, 030217 neurology & neurosurgery, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd56a26eaed0bb2a4cfdf03b4b10e492Test
https://doaj.org/article/bd282779d343414aa689f312c255a80fTest

المؤلفون: Karen Hayes, Reina N. Fuji, Lisa L. Shafer, Saileta Prabhu, William J. Meilandt, Keith R. Hildebrand, Ryan J. Watts, Thomas Keene, Jessica Couch, Blair Wilson, Jasvinder K. Atwal, Janice A. Maloney, Ann L. Daugherty, Kapil Gadkar, Kimberly Scearce-Levie, Kristin R. Wildsmith, Yanmei Lu, Andrew Kosky, Marisa Goo, Robert C. Switzer, Kun Peng, Eric Adams, Deepak R. Thakker, Pamela Chan, Deanna S. Lane, Lisa Jungbauer Nikolas, Hilda Solanoy, Daniela Bumbaca Yadav

المصدر: British Journal of Pharmacology. 174:4173-4185

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, biology, Continuous infusion, medicine.drug_class, business.industry, Inhibitory postsynaptic potential, Monoclonal antibody, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Pharmacokinetics, mental disorders, Parenchyma, Immunology, biology.protein, medicine, Antibody, business, Amyloid precursor protein secretase, I²C, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4e0802c2e55ddcc52775ac9687bc8dd4Test
https://doi.org/10.1111/bph.14021Test

المؤلفون: Claire E. Le Pichon, Joseph W. Lewcock, Eric J. Huang, Richard A.D. Carano, Michael Siu, Hai Ngu, Arundhati Sengupta Ghosh, Sebum Lee, Xingrong Liu, Zhiyu Jiang, William J. Meilandt, York Rudhard, Amy Gustafson, Sara L. Dominguez, Han Lin, Robby M. Weimer, Seung-Hye Lee, Bei Wang, Christine Pozniak, Snahel Patel, Vineela D. Gandham, Hilda Solanoy, Oded Foreman, Alvin Gogineni, Janice A. Maloney, Miriam Baca, Josh Kaminker, Zora Modrusan, Kimberly Scearce-Levie

المصدر: Science translational medicine, vol 9, iss 403

مصطلحات موضوعية: 0301 basic medicine, Aging, Programmed cell death, Leucine zipper, MAP Kinase Signaling System, Transgene, Regulator, Mice, Transgenic, Neurodegenerative, Biology, Medical and Health Sciences, Neuroprotection, Transgenic, Mice, 03 medical and health sciences, Alzheimer Disease, medicine, 2.1 Biological and endogenous factors, Animals, Humans, Amyotrophic lateral sclerosis, Protein Kinase Inhibitors, Leucine Zippers, Animal, Superoxide Dismutase, Amyotrophic Lateral Sclerosis, Neurodegeneration, Neurosciences, JNK Mitogen-Activated Protein Kinases, Neurodegenerative Diseases, General Medicine, Biological Sciences, MAP Kinase Kinase Kinases, medicine.disease, Brain Disorders, Cell biology, Disease Models, Animal, 030104 developmental biology, Gene Expression Regulation, Spinal Cord, Biochemistry, Disease Models, Neurological, Signal transduction, Gene Deletion, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856b450587a96da8f40dd09f8f3178deTest
https://doi.org/10.1126/scitranslmed.aag0394Test

المؤلفون: Ryan J. Watts, Richard Mayeux, Timothy W. Behrens, Oded Foreman, Ward Ortmann, Gerard D. Schellenberg, Julie Hunkapiller, Lindsay A. Farrer, Susan M Sa, Robert R. Graham, Tushar Bhangale, Murat Yaylaoglu, Carlos Cruchaga, Jasvinder K. Atwal, Jonathan L. Haines, Nisha Rathore, Karpagam Srinivasan, Margaret A. Pericak-Vance, Marc Tessier-Lavigne, Janice A. Maloney, David V. Hansen, Alison Goate, Monica K Wetzel-Smith

المصدر: Nature Medicine. 20:1452-1457

مصطلحات موضوعية: Programmed cell death, Mutation, HEK 293 cells, Late onset, General Medicine, Disease, Biology, UNC5C, medicine.disease, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Immunology, medicine, Alzheimer's disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ba6d1694b0f4fcc3b849cfaaf240338cTest
https://doi.org/10.1038/nm.3736Test

المؤلفون: Yichin Liu, Ryan J. Watts, Travis W. Bainbridge, Pascal Steiner, Shuo Zhang, Jasvinder Atwal, Marcel P. van der Brug, James A. Ernst, Amy Gustafson, Janice A. Maloney, Roxanne Kyauk

المصدر: Journal of Biological Chemistry. 289:30990-31000

مصطلحات موضوعية: Heterozygote, DNA, Complementary, Mutant, Plasma protein binding, Biochemistry, Catalysis, Amyloid beta-Protein Precursor, Inhibitory Concentration 50, Mice, Neurobiology, Alzheimer Disease, mental disorders, Fluorescence Resonance Energy Transfer, medicine, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, Molecular Biology, Alleles, Neurons, Amyloid beta-Peptides, biology, Chemistry, HEK 293 cells, Proteolytic enzymes, P3 peptide, Cell Biology, medicine.disease, Molecular biology, Peptide Fragments, Mice, Inbred C57BL, Kinetics, HEK293 Cells, Mutation, biology.protein, Microglia, Amyloid Precursor Protein Secretases, Alzheimer's disease, Amyloid precursor protein secretase, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca9a538edf2482e6b662393bb902d7bTest
https://doi.org/10.1074/jbc.m114.589069Test

المؤلفون: Chung Kung, Shannon D. Shields, Sara L. Dominguez, Timothy K. Earr, Janice A. Maloney, Martin Weber, Kimberly Scearce-Levie, Ryan J. Watts, William F. Forrest, Tiffany Wu, Søren Warming, William J. Meilandt, Oded Foreman, Hilda Solanoy, Daniel Fleck, Hai Ngu, Lisa Lima, Miriam Baca

المصدر: Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Reflex, Startle, Context (language use), Motor Activity, Article, 03 medical and health sciences, Species Specificity, In vivo, Alzheimer Disease, Internal medicine, mental disorders, medicine, Animals, Aspartic Acid Endopeptidases, Humans, Prepulse inhibition, chemistry.chemical_classification, Mice, Knockout, Nuclease, Multidisciplinary, biology, Prepulse Inhibition, Body Weight, Phenotype, Rats, Mice, Inbred C57BL, 030104 developmental biology, Enzyme, Endocrinology, chemistry, Knockout mouse, biology.protein, Reflex, Amyloid Precursor Protein Secretases, Gene Deletion

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51eaad6cfcc64da59b6916bd5a09a0e2Test
https://pubmed.ncbi.nlm.nih.gov/28281673Test

المؤلفون: Mark Z. Chen, Dara Y. Kallop, Kristin Baer, Holger Kissel, Joshua S. Kaminker, Janice A. Maloney, Jasvinder Atwal, Stephen J. Tam, Joseph W. Lewcock, Robby M. Weimer, Ryan J. Watts

المصدر: The Journal of Neuroscience. 32:13439-13453

مصطلحات موضوعية: Male, Retinal Ganglion Cells, Nervous system, Degeneration (medical), Hippocampus, Glycogen Synthase Kinase 3, Mice, Ganglia, Spinal, Nerve Growth Factor, Enzyme Inhibitors, Phosphorylation, RNA, Small Interfering, Axon, Cells, Cultured, Oligonucleotide Array Sequence Analysis, Neurons, Kinase, General Neuroscience, Gene Expression Regulation, Developmental, Articles, Cell biology, Electroporation, medicine.anatomical_structure, Female, Signal Transduction, Gene isoform, Genotype, MAP Kinase Signaling System, TBX6, Green Fluorescent Proteins, Mice, Transgenic, Nerve Tissue Proteins, Biology, Transfection, Organ Culture Techniques, medicine, Animals, Humans, Immunoprecipitation, Glycogen synthase, Transcription factor, Glycogen Synthase Kinase 3 beta, Gene Expression Profiling, Phosphotransferases, Embryo, Mammalian, Axons, Mice, Inbred C57BL, Luminescent Proteins, Animals, Newborn, nervous system, Mutation, Nerve Degeneration, biology.protein, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b3385b3371965516179f7b5f027a27Test
https://doi.org/10.1523/jneurosci.2039-12.2012Test

المؤلفون: Aarno Palotie, Daniel F. Gudbjartsson, Stacy Steinberg, Thorlakur Jonsson, Augustine Kong, Kari Stefansson, Jon Snaedal, Ryan J. Watts, Timothy W. Behrens, Patrick Sulem, Palmi V. Jonsson, Kwame Hoyte, Unnur Thorsteinsdottir, Yichin Liu, Gyda Bjornsdottir, Sigurbjorn Bjornsson, Ole A. Andreassen, Olafur T. Magnusson, Johanna Huttenlocher, Robert R. Graham, Erik G. Jönsson, Amy Gustafson, Janice A. Maloney, Yanmei Lu, Jasvinder K. Atwal, Hreinn Stefansson, Tushar Bhangale

المصدر: Nature. 488:96-99

مصطلحات موضوعية: Aging, Age-related cognitive decline, Plaque, Amyloid, Disease, Amyloid beta-Protein Precursor, 03 medical and health sciences, Cognition, 0302 clinical medicine, Alzheimer Disease, Amyloid precursor protein, Aspartic Acid Endopeptidases, Humans, Medicine, Dementia, Genetic Predisposition to Disease, Cognitive decline, Allele, Gene, Alleles, 030304 developmental biology, 0303 health sciences, Multidisciplinary, biology, business.industry, medicine.disease, HEK293 Cells, Mutation, Immunology, biology.protein, Verubecestat, Amyloid Precursor Protein Secretases, Cognition Disorders, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7408df1fc876b3360c1866a2f5d5ee26Test
https://doi.org/10.1038/nature11283Test

المؤلفون: Yvan Varisco, Kasia Piorkowska, Maria Pihlgren, Oskar Adolfsson, Mark Z. Chen, Alvin Gogineni, Nicolas Toni, Carole Ho, Andreas Muhs, Andrea Pfeifer, Katia Antoniello, Michel Friesenhahn, Robby M. Weimer, Sophie Lohmann, Robert Paul, Valerie Gafner, Anna Lucia Buccarello, Janice A. Maloney, Deborah L. Mortensen, Ryan J. Watts, Jasvinder Atwal

المصدر: The Journal of neuroscience : the official journal of the Society for Neuroscience
Journal of Neuroscience, vol. 32, no. 28, pp. 9677-9689

مصطلحات موضوعية: Male, Time Factors, Plaque, Amyloid, Hippocampus, p38 Mitogen-Activated Protein Kinases, Rats, Sprague-Dawley, Amyloid beta-Protein Precursor, Mice, 0302 clinical medicine, CX3CR1, Cells, Cultured, Aged, 80 and over, Cerebral Cortex, Neurons, 0303 health sciences, Microscopy, Confocal, Microglia, General Neuroscience, Articles, Middle Aged, 3. Good health, Neuroprotective Agents, medicine.anatomical_structure, Female, Receptors, Chemokine, Protein Binding, medicine.drug, Amyloid, Green Fluorescent Proteins, CX3C Chemokine Receptor 1, Dose-Response Relationship, Immunologic, Enzyme-Linked Immunosorbent Assay, Mice, Transgenic, Biology, Neuroprotection, Statistics, Nonparametric, Proinflammatory cytokine, 03 medical and health sciences, Double-Blind Method, Alzheimer Disease, Presenilin-1, medicine, Animals, Humans, Bapineuzumab, Aged, Alzheimer Disease/blood, Alzheimer Disease/immunology, Amyloid beta-Peptides/immunology, Amyloid beta-Peptides/metabolism, Amyloid beta-Protein Precursor/genetics, Animals, Newborn, Cerebral Cortex/cytology, Disease Models, Animal, Dose-Response Relationship, Drug, Gene Expression Regulation/drug effects, Gene Expression Regulation/genetics, Green Fluorescent Proteins/genetics, Hippocampus/cytology, Immunoglobulin G/metabolism, Immunoglobulin G/pharmacology, Microglia/drug effects, Microglia/metabolism, Mutation/genetics, Neurons/drug effects, Neurons/metabolism, Neuroprotective Agents/metabolism, Neuroprotective Agents/pharmacology, Peptide Fragments/metabolism, Plaque, Amyloid/immunology, Plaque, Amyloid/metabolism, Presenilin-1/genetics, Protein Binding/drug effects, Rats, Receptors, Chemokine/genetics, Tumor Necrosis Factor-alpha/metabolism, p38 Mitogen-Activated Protein Kinases/metabolism, 030304 developmental biology, Amyloid beta-Peptides, Tumor Necrosis Factor-alpha, Peptide Fragments, Gene Expression Regulation, Immunoglobulin G, Mutation, Crenezumab, Immunology, Cancer research, Gantenerumab, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2cbe1eb7083c2049180d072e90c4036Test