المؤلفون: Betty Chau, Joseph D. Ho, Francisco J Agejas, Francis S. Willard, Ana B. Bueno, Tong Sun Kobilka, Brian K. Kobilka, Isabel Rojo, James Ficorilli, Bingfa Sun, Aaron D. Showalter, Qi Chen, Cynthia Stutsman, Dan Feng, Kyle W. Sloop, Michal Vieth, Alma Jiménez, David B. Wainscott, Graham R Cumming

المصدر: Nature Chemical Biology. 16:1105-1110

مصطلحات موضوعية: 0303 health sciences, Allosteric modulator, Chemistry, Drug discovery, 030302 biochemistry & molecular biology, Allosteric regulation, Cell Biology, Ligand (biochemistry), 03 medical and health sciences, Heterotrimeric G protein, Biophysics, Receptor, Molecular Biology, hormones, hormone substitutes, and hormone antagonists, Glucagon-like peptide 1 receptor, 030304 developmental biology, G protein-coupled receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a220ba28f95c8886d1e77753f8c975b0Test
https://doi.org/10.1038/s41589-020-0589-7Test

المؤلفون: David B. Wainscott, Francis S. Willard, Fariba Norouziyan Cooper, James Ficorilli, Kyle W. Sloop, Jorge Alsina-Fernandez, William C. Roell, Tamer Coskun, Over Cabrera, Shweta Urva, Aaron D. Showalter, Libbey S. O’Farrell, Xiaoping Ruan, Hongchang Qu, Julie S. Moyers, Ajit Regmi, Lili Guo

المصدر: Diabetes. 70

مصطلحات موضوعية: Agonist, medicine.medical_specialty, Gastric emptying, business.industry, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Incretin, medicine.disease, Glucagon, Obesity, law.invention, Endocrinology, law, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Recombinant DNA, business, Diet-induced obese

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ce73da18004f9da5ae151ab81bea87dcTest
https://doi.org/10.2337/db21-679-pTest

المؤلفون: Over Cabrera, James Ficorilli, Janice Shaw, Felipe Echeverri, Frank Schwede, Oleg G. Chepurny, Colin A. Leech, George G. Holz

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: endocrine system, insulin secretion, OGTT, oral glucose tolerance test, GcgR, glucagon receptor, GRA, GcgR antagonist, T2D, type 2 diabetes, Biochemistry, Glucagon-Like Peptide-1 Receptor, GSIS, glucose-stimulated insulin secretion, Islets of Langerhans, Mice, CM, conditioned medium, Glucagon-Like Peptide 1, cAMP, Animals, Insulin, Molecular Biology, islet, digestive, oral, and skin physiology, Cell Biology, Glucagon, SES, standard extracellular saline, Rats, Mice, Inbred C57BL, Glucose, Diabetes Mellitus, Type 2, IVGTT, intravenous glucose tolerance test, AUC, area-under-the-curve, BSA, bovine serum albumin, GLP-1, hormones, hormone substitutes, and hormone antagonists, Research Article, GLP-1R, glucagon-like peptide-1 receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43acc34886e5599447ad731f8d2aba40Test
https://doi.org/10.1016/j.jbc.2021.101484Test

المؤلفون: Ana B, Bueno, Bingfa, Sun, Francis S, Willard, Dan, Feng, Joseph D, Ho, David B, Wainscott, Aaron D, Showalter, Michal, Vieth, Qi, Chen, Cynthia, Stutsman, Betty, Chau, James, Ficorilli, Francisco J, Agejas, Graham R, Cumming, Alma, Jiménez, Isabel, Rojo, Tong Sun, Kobilka, Brian K, Kobilka, Kyle W, Sloop

المصدر: Nature chemical biology. 16(10)

مصطلحات موضوعية: Models, Molecular, Allosteric Regulation, Molecular Structure, Glucagon-Like Peptide 1, Protein Conformation, Allosteric Site, Glucagon-Like Peptide-1 Receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::2d81110a8c0f747bb636b179a10be509Test
https://pubmed.ncbi.nlm.nih.gov/32690941Test

المؤلفون: Marta Adeva, Samreen K. Syed, Thomas B. Farb, Xin Zhou, Thomas James Beauchamp, David Andrew Coates, Francis S. Willard, Tamika D. Meredith, Susan L. Gackenheimer, Michael A. Statnick, Maria Angeles Martinez-Grau, Miguel A. Toledo, Brian A. Droz, James Ficorilli, Alexander M. Efanov, Gema Ruano, Over Cabrera, Todd M. Suter, Victoriano Molero, Krister Bokvist, David Gene Barrett

المصدر: Endocrinology. 158:3859-3873

مصطلحات موضوعية: Male, 0301 basic medicine, endocrine system, medicine.medical_specialty, medicine.medical_treatment, Incretin, CHO Cells, Benzoates, Rats, Sprague-Dawley, Islets of Langerhans, Mice, 03 medical and health sciences, Cricetulus, Endocrinology, Glucagon-Like Peptide 1, Cricetinae, Internal medicine, Insulin Secretion, medicine, Animals, Humans, Hypoglycemic Agents, Insulin, Somatostatin receptor 2, Spiro Compounds, Somatostatin receptor 1, Receptors, Somatostatin, education, Cells, Cultured, Glycemic, Mice, Knockout, education.field_of_study, Secretory Pathway, Somatostatin receptor-5, business.industry, Rats, Rats, Zucker, Mice, Inbred C57BL, HEK293 Cells, 030104 developmental biology, Somatostatin, Antagonism, business, hormones, hormone substitutes, and hormone antagonists

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7117b32696fece4fccc94de0254d0fTest
https://doi.org/10.1210/en.2017-00639Test

المؤلفون: Alexander G. Obukhov, James Ficorilli, Samreen K. Syed, Over Cabrera, Rok Cerne, Wenzhen Ma, Xingjuan Chen, Alexander M. Efanov

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, medicine.drug_class, Metabolite, Endogeny, Carbohydrate metabolism, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Transient receptor potential channel, Mice, Internal medicine, Insulin-Secreting Cells, Insulin Secretion, medicine, Glucose homeostasis, Animals, Humans, Molecular Biology, TRPA1 Cation Channel, Cells, Cultured, 030102 biochemistry & molecular biology, HEK 293 cells, Cell Biology, Estrogens, Catechol, Rats, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Glucose, chemistry, Gene Expression Regulation, Estrogen, hormones, hormone substitutes, and hormone antagonists, Hormone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3aaadb27589263a635cdcbdf75185a3Test
https://europepmc.org/articles/PMC6393604Test/

المؤلفون: Anne Reifel Miller, Marialuisa C. Marcelo, Qi Chen, Ruth Belin, Pranab Maiti, Joseph V. Haas, Jared L. Piper, Ellen A. Cannady, Steven D. Kahl, Anjana Patel Lewis, Guemalli R. Cardona, Jason T. Johnson, D. Scott Coffey, Dawn A. Brooks, James Ficorilli, Xiaosu Ma, Sweetana Stephanie Ann, Chafiq Hamdouchi, Yanyun Chen, Edward J. Pratt, Keyue Chen, Richard W. Zink, Kelly L. Wilbur, Keith A. Otto, Mark A. Deeg, Nathan Yumibe, Jayana Pankaj Lineswala, Thomas E Eessalu, Chahrzad Montrose-Rafizadeh

المصدر: Journal of medicinal chemistry. 59(24)

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_treatment, Endogeny, Pharmacology, Diabetes Mellitus, Experimental, Receptors, G-Protein-Coupled, 03 medical and health sciences, Mice, Structure-Activity Relationship, Pharmacokinetics, Piperidines, Free fatty acid receptor 1, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Secretion, Spiro Compounds, Receptor, geography, Mice, Inbred BALB C, geography.geographical_feature_category, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Insulin, Type 2 Diabetes Mellitus, Glucose Tolerance Test, Islet, Rats, Rats, Zucker, Mice, Inbred C57BL, 030104 developmental biology, HEK293 Cells, Diabetes Mellitus, Type 2, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e874164fca96fc6edd42ba967fc574bTest
https://pubmed.ncbi.nlm.nih.gov/27749056Test

المؤلفون: Francis S. Willard, Denise Wootten, Kyle W. Sloop, Krister Bokvist, James Ficorilli, Patrick M. Sexton, Jorge Alsina-Fernandez, Thomas B. Farb, Arthur Christopoulos, Emilia Elizabeth Savage, Aaron D. Showalter, Sebastian Gb Furness

المصدر: Molecular Pharmacology. 82:1066-1073

مصطلحات موضوعية: Agonist, medicine.drug_class, Allosteric regulation, CHO Cells, Biology, Glucagon-Like Peptide-1 Receptor, Cell Line, chemistry.chemical_compound, GTP-Binding Proteins, Glucagon-Like Peptide 1, Cricetinae, Heterotrimeric G protein, Cyclic AMP, Receptors, Glucagon, medicine, Animals, Humans, Hypoglycemic Agents, Insulin, Receptor, Receptor modulator, Pharmacology, Drug Synergism, Small molecule, Cell biology, Oxyntomodulin, HEK293 Cells, Diabetes Mellitus, Type 2, chemistry, Biochemistry, Molecular Medicine, Signal transduction, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce8406034b3aae8e19b18f2f1608614Test
https://doi.org/10.1124/mol.112.080432Test

المؤلفون: Amy L. Cox, Kyle W. Sloop, Bethany P. Cummings, M. Dodson Michael, James Ficorilli, Anne K. McGavigan, Seon A. Lee, Darline Garibay

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, medicine.medical_treatment, 030209 endocrinology & metabolism, Biology, Glucagon-Like Peptide-1 Receptor, Impaired glucose tolerance, 03 medical and health sciences, Eating, 0302 clinical medicine, Endocrinology, Glucose Metabolism Disorder, Gastrectomy, Internal medicine, Insulin-Secreting Cells, parasitic diseases, Insulin Secretion, medicine, Glucose homeostasis, Animals, Insulin, Glucose Metabolism Disorders, Mice, Knockout, Glucose tolerance test, medicine.diagnostic_test, digestive, oral, and skin physiology, Body Weight, Brief Research Report, Glucose Tolerance Test, medicine.disease, Glucagon-like peptide-1, Tamoxifen, 030104 developmental biology, Postprandial, Blood sugar regulation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f37571c473de45e93d4340f7075ed12Test
https://europepmc.org/articles/PMC5007900Test/

المؤلفون: Bernhard Maier, Sarah A. Tersey, Raghavendra G. Mirmira, Takeshi Ogihara, Krister Bokvist, Reiesha D. Robbins, Thomas B. Farb, James Ficorilli, Dhananjay Gupta

المصدر: Journal of Biological Chemistry. 285:39943-39952

مصطلحات موضوعية: Cell Survival, Peptide Chain Elongation, Translational, Apoptosis, Biology, CHOP, Endoplasmic Reticulum, Biochemistry, Mice, chemistry.chemical_compound, Peptide Initiation Factors, Insulin-Secreting Cells, Enhancer binding, Animals, Deoxyhypusine synthase, Enzyme Inhibitors, Molecular Biology, Transcription Factor CHOP, Hypusine, Oxidoreductases Acting on CH-NH Group Donors, Caspase 3, Endoplasmic reticulum, RNA-Binding Proteins, Molecular Bases of Disease, Cell Biology, Molecular biology, Mice, Mutant Strains, Diabetes Mellitus, Type 2, chemistry, Unfolded Protein Response, biology.protein, Unfolded protein response, Thapsigargin, Translational elongation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3451e047f0274476006c4e8fb544a6e1Test
https://doi.org/10.1074/jbc.m110.170142Test